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Late-life depression, mild cognitive impairment, and dementia.
JAMA Neurol. 2013 Mar 01; 70(3):374-82.JN

Abstract

OBJECTIVE

To evaluate the association of late-life depression with mild cognitive impairment (MCI) and dementia in a multiethnic community cohort.

DESIGN AND SETTING

A cohort study was conducted in Northern Manhattan, New York, New York.

PARTICIPANTS

A total of 2160 community-dwelling Medicare recipients aged 65 years or older were included in the study.

METHODS

Depression was assessed using the 10-item version of the Center for Epidemiological Studies Depression scale (CES-D) and defined by a CES-D score of 4 or more. We used logistic regression for cross-sectional association analyses and proportional hazards regression for longitudinal analyses.

MAIN OUTCOME MEASURES

Mild cognitive impairment dementia, and progression from MCI to dementia were the main outcome measures. We also used subcategories of MCI (amnestic and nonamnestic), and dementia (probable Alzheimer disease and vascular dementia, including possible Alzheimer disease with stroke).

RESULTS

Baseline depression was associated with prevalent MCI (odds ratio, 1.4; 95% CI, 1.1-1.9) and dementia (2.2; 1.6-3.1). Baseline depression was associated with an increased risk of incident dementia (hazard ratio [HR], 1.7; 95% CI, 1.2-2.3) but not with incident MCI (0.9; 0.7-1.2). Persons with MCI and coexisting depression at baseline had a higher risk of progression to dementia (HR, 2.0; 95% CI, 1.2-3.4), especially vascular dementia (4.3; 1.1-17.0), but not Alzheimer disease (1.9; 1.0-3.6).

CONCLUSION

The association of depression with prevalent MCI and with progression from MCI to dementia, but not with incident MCI, suggests that depression accompanies cognitive impairment but does not precede it.

Authors+Show Affiliations

Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

23599941

Citation

Richard, Edo, et al. "Late-life Depression, Mild Cognitive Impairment, and Dementia." JAMA Neurology, vol. 70, no. 3, 2013, pp. 374-82.
Richard E, Reitz C, Honig LH, et al. Late-life depression, mild cognitive impairment, and dementia. JAMA Neurol. 2013;70(3):374-82.
Richard, E., Reitz, C., Honig, L. H., Schupf, N., Tang, M. X., Manly, J. J., Mayeux, R., Devanand, D., & Luchsinger, J. A. (2013). Late-life depression, mild cognitive impairment, and dementia. JAMA Neurology, 70(3), 374-82.
Richard E, et al. Late-life Depression, Mild Cognitive Impairment, and Dementia. JAMA Neurol. 2013 Mar 1;70(3):374-82. PubMed PMID: 23599941.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Late-life depression, mild cognitive impairment, and dementia. AU - Richard,Edo, AU - Reitz,Christiane, AU - Honig,Lawrence H, AU - Schupf,Nicole, AU - Tang,Ming X, AU - Manly,Jennifer J, AU - Mayeux,Richard, AU - Devanand,Devangere, AU - Luchsinger,José A, PY - 2013/4/20/entrez PY - 2013/4/20/pubmed PY - 2013/4/30/medline SP - 374 EP - 82 JF - JAMA neurology JO - JAMA Neurol VL - 70 IS - 3 N2 - OBJECTIVE: To evaluate the association of late-life depression with mild cognitive impairment (MCI) and dementia in a multiethnic community cohort. DESIGN AND SETTING: A cohort study was conducted in Northern Manhattan, New York, New York. PARTICIPANTS: A total of 2160 community-dwelling Medicare recipients aged 65 years or older were included in the study. METHODS: Depression was assessed using the 10-item version of the Center for Epidemiological Studies Depression scale (CES-D) and defined by a CES-D score of 4 or more. We used logistic regression for cross-sectional association analyses and proportional hazards regression for longitudinal analyses. MAIN OUTCOME MEASURES: Mild cognitive impairment dementia, and progression from MCI to dementia were the main outcome measures. We also used subcategories of MCI (amnestic and nonamnestic), and dementia (probable Alzheimer disease and vascular dementia, including possible Alzheimer disease with stroke). RESULTS: Baseline depression was associated with prevalent MCI (odds ratio, 1.4; 95% CI, 1.1-1.9) and dementia (2.2; 1.6-3.1). Baseline depression was associated with an increased risk of incident dementia (hazard ratio [HR], 1.7; 95% CI, 1.2-2.3) but not with incident MCI (0.9; 0.7-1.2). Persons with MCI and coexisting depression at baseline had a higher risk of progression to dementia (HR, 2.0; 95% CI, 1.2-3.4), especially vascular dementia (4.3; 1.1-17.0), but not Alzheimer disease (1.9; 1.0-3.6). CONCLUSION: The association of depression with prevalent MCI and with progression from MCI to dementia, but not with incident MCI, suggests that depression accompanies cognitive impairment but does not precede it. SN - 2168-6157 UR - https://www.unboundmedicine.com/medline/citation/23599941/Late_life_depression_mild_cognitive_impairment_and_dementia_ L2 - https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/jamaneurol.2013.603 DB - PRIME DP - Unbound Medicine ER -