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Harnessing the power of yeast to unravel the molecular basis of neurodegeneration.
J Neurochem. 2013 Nov; 127(4):438-52.JN

Abstract

Several neurodegenerative diseases, such as Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), or prion diseases, are known for their intimate association with protein misfolding and aggregation. These disorders are characterized by the loss of specific neuronal populations in the brain and are highly associated with aging, suggesting a decline in proteostasis capacity may contribute to pathogenesis. Nevertheless, the precise molecular mechanisms that lead to the selective demise of neurons remain poorly understood. As a consequence, appropriate therapeutic approaches and effective treatments are largely lacking. The development of cellular and animal models that faithfully reproduce central aspects of neurodegeneration has been crucial for advancing our understanding of these diseases. Approaches involving the sequential use of different model systems, starting with simpler cellular models and ending with validation in more complex animal models, resulted in the discovery of promising therapeutic targets and small molecules with therapeutic potential. Within this framework, the simple and well-characterized eukaryote Saccharomyces cerevisiae, also known as budding yeast, is being increasingly used to study the molecular basis of several neurodegenerative disorders. Yeast provides an unprecedented toolbox for the dissection of complex biological processes and pathways. Here, we summarize how yeast models are adding to our current understanding of several neurodegenerative disorders.

Authors+Show Affiliations

Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

23600759

Citation

Tenreiro, Sandra, et al. "Harnessing the Power of Yeast to Unravel the Molecular Basis of Neurodegeneration." Journal of Neurochemistry, vol. 127, no. 4, 2013, pp. 438-52.
Tenreiro S, Munder MC, Alberti S, et al. Harnessing the power of yeast to unravel the molecular basis of neurodegeneration. J Neurochem. 2013;127(4):438-52.
Tenreiro, S., Munder, M. C., Alberti, S., & Outeiro, T. F. (2013). Harnessing the power of yeast to unravel the molecular basis of neurodegeneration. Journal of Neurochemistry, 127(4), 438-52. https://doi.org/10.1111/jnc.12271
Tenreiro S, et al. Harnessing the Power of Yeast to Unravel the Molecular Basis of Neurodegeneration. J Neurochem. 2013;127(4):438-52. PubMed PMID: 23600759.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Harnessing the power of yeast to unravel the molecular basis of neurodegeneration. AU - Tenreiro,Sandra, AU - Munder,Matthias C, AU - Alberti,Simon, AU - Outeiro,Tiago F, Y1 - 2013/05/08/ PY - 2013/03/09/received PY - 2013/04/02/revised PY - 2013/04/04/accepted PY - 2013/4/23/entrez PY - 2013/4/23/pubmed PY - 2014/1/7/medline KW - S. cerevisiae KW - amyloid KW - neurodegeneration KW - prion KW - protein aggregation KW - protein misfolding SP - 438 EP - 52 JF - Journal of neurochemistry JO - J. Neurochem. VL - 127 IS - 4 N2 - Several neurodegenerative diseases, such as Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), or prion diseases, are known for their intimate association with protein misfolding and aggregation. These disorders are characterized by the loss of specific neuronal populations in the brain and are highly associated with aging, suggesting a decline in proteostasis capacity may contribute to pathogenesis. Nevertheless, the precise molecular mechanisms that lead to the selective demise of neurons remain poorly understood. As a consequence, appropriate therapeutic approaches and effective treatments are largely lacking. The development of cellular and animal models that faithfully reproduce central aspects of neurodegeneration has been crucial for advancing our understanding of these diseases. Approaches involving the sequential use of different model systems, starting with simpler cellular models and ending with validation in more complex animal models, resulted in the discovery of promising therapeutic targets and small molecules with therapeutic potential. Within this framework, the simple and well-characterized eukaryote Saccharomyces cerevisiae, also known as budding yeast, is being increasingly used to study the molecular basis of several neurodegenerative disorders. Yeast provides an unprecedented toolbox for the dissection of complex biological processes and pathways. Here, we summarize how yeast models are adding to our current understanding of several neurodegenerative disorders. SN - 1471-4159 UR - https://www.unboundmedicine.com/medline/citation/23600759/Harnessing_the_power_of_yeast_to_unravel_the_molecular_basis_of_neurodegeneration_ L2 - https://doi.org/10.1111/jnc.12271 DB - PRIME DP - Unbound Medicine ER -