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Modulation of serum smooth muscle antibody levels by levamisole treatment in patients with oral lichen planus.
J Formos Med Assoc. 2013 Jun; 112(6):352-7.JF

Abstract

BACKGROUND/PURPOSE

Serum autoantibodies have been found in patients with oral lichen planus (OLP). This study evaluated whether OLP patients had significantly higher frequencies of serum smooth muscle antibody (SMA) than healthy control individuals, and assessed whether levamisole treatment could modulate the serum SMA levels in OLP patients.

METHODS

This study used an indirect immunofluorescence technique to measure the baseline serum SMA levels in a group of 647 OLP patients and 53 controls. Ninety-five SMA-positive OLP patients were treated with levamisole under a regular follow-up schedule, and their serum SMA levels were measured after treatment.

RESULTS

The frequencies of serum SMA in patients with OLP (21.9%), erosive OLP (EOLP, 21.6%), major EOLP (17.9%), minor EOLP (24.2%), and nonerosive OLP (24.4%) were all significantly higher than that (0%) in healthy controls (all p < 0.001). Of 142 SMA-positive OLP patients, 95 were treated with levamisole under a regular follow-up schedule. Treatment with levamisole for a period of 2-29 months (mean, 9.4 ± 6.0 months) effectively reduced the high mean serum SMA titer (71.0 ± 7.2) at baseline to an undetectable level (0) in all SMA-positive OLP patients, regardless of different initial serum SMA titers.

CONCLUSION

There was a significantly higher frequency of serum SMA (21.9%) in OLP patients than in healthy controls. Treatment with levamisole for 2-29 months significantly reduced the high serum SMA to an undetectable level, and significantly improved the signs and symptoms in all treated OLP patients.

Authors+Show Affiliations

Department of Dentistry, College of Medicine, National Taiwan University Hospital, 1 Chang-Te Street, Taipei, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23602020

Citation

Wu, Kai-Ming, et al. "Modulation of Serum Smooth Muscle Antibody Levels By Levamisole Treatment in Patients With Oral Lichen Planus." Journal of the Formosan Medical Association = Taiwan Yi Zhi, vol. 112, no. 6, 2013, pp. 352-7.
Wu KM, Wang YP, Lin HP, et al. Modulation of serum smooth muscle antibody levels by levamisole treatment in patients with oral lichen planus. J Formos Med Assoc. 2013;112(6):352-7.
Wu, K. M., Wang, Y. P., Lin, H. P., Chen, H. M., Chia, J. S., & Sun, A. (2013). Modulation of serum smooth muscle antibody levels by levamisole treatment in patients with oral lichen planus. Journal of the Formosan Medical Association = Taiwan Yi Zhi, 112(6), 352-7. https://doi.org/10.1016/j.jfma.2013.03.003
Wu KM, et al. Modulation of Serum Smooth Muscle Antibody Levels By Levamisole Treatment in Patients With Oral Lichen Planus. J Formos Med Assoc. 2013;112(6):352-7. PubMed PMID: 23602020.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modulation of serum smooth muscle antibody levels by levamisole treatment in patients with oral lichen planus. AU - Wu,Kai-Ming, AU - Wang,Yi-Ping, AU - Lin,Hung-Pin, AU - Chen,Hsin-Ming, AU - Chia,Jean-San, AU - Sun,Andy, Y1 - 2013/04/18/ PY - 2013/02/19/received PY - 2013/03/10/accepted PY - 2013/4/23/entrez PY - 2013/4/23/pubmed PY - 2014/1/31/medline SP - 352 EP - 7 JF - Journal of the Formosan Medical Association = Taiwan yi zhi JO - J Formos Med Assoc VL - 112 IS - 6 N2 - BACKGROUND/PURPOSE: Serum autoantibodies have been found in patients with oral lichen planus (OLP). This study evaluated whether OLP patients had significantly higher frequencies of serum smooth muscle antibody (SMA) than healthy control individuals, and assessed whether levamisole treatment could modulate the serum SMA levels in OLP patients. METHODS: This study used an indirect immunofluorescence technique to measure the baseline serum SMA levels in a group of 647 OLP patients and 53 controls. Ninety-five SMA-positive OLP patients were treated with levamisole under a regular follow-up schedule, and their serum SMA levels were measured after treatment. RESULTS: The frequencies of serum SMA in patients with OLP (21.9%), erosive OLP (EOLP, 21.6%), major EOLP (17.9%), minor EOLP (24.2%), and nonerosive OLP (24.4%) were all significantly higher than that (0%) in healthy controls (all p < 0.001). Of 142 SMA-positive OLP patients, 95 were treated with levamisole under a regular follow-up schedule. Treatment with levamisole for a period of 2-29 months (mean, 9.4 ± 6.0 months) effectively reduced the high mean serum SMA titer (71.0 ± 7.2) at baseline to an undetectable level (0) in all SMA-positive OLP patients, regardless of different initial serum SMA titers. CONCLUSION: There was a significantly higher frequency of serum SMA (21.9%) in OLP patients than in healthy controls. Treatment with levamisole for 2-29 months significantly reduced the high serum SMA to an undetectable level, and significantly improved the signs and symptoms in all treated OLP patients. SN - 0929-6646 UR - https://www.unboundmedicine.com/medline/citation/23602020/Modulation_of_serum_smooth_muscle_antibody_levels_by_levamisole_treatment_in_patients_with_oral_lichen_planus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0929-6646(13)00119-8 DB - PRIME DP - Unbound Medicine ER -