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Iron supplementation decreases plasma zinc but has no effect on plasma fatty acids in non-anemic women.
Nutr Res. 2013 Apr; 33(4):272-8.NR

Abstract

Limited information is available on the role of iron in fatty acid metabolism in humans. We hypothesized that iron supplementation will increase desaturase activity, and so, the aim of this study was to determine the effect of iron supplementation on fatty acid desaturase activity in young women. Participants were randomly assigned to a control group (CG) or supplementation group (SG) who were provided with 37.4 mg of elemental iron daily for 12 weeks. Forty women completed the trial, n = 19 in CG and n = 21 in SG. The mean ages were 25.2 and 24.6 years, and body mass indices were 21.8 and 21.2 (kg/m(2)) in CG and SG, respectively. Serum ferritin concentrations increased significantly (P < .01) in subjects assigned to SG but were unchanged in CG. Serum iron concentrations were not significantly changed. Plasma zinc concentrations at the end of the intervention were similar to baseline values for individuals in CG but were decreased significantly (P = .004) in SG. Plasma fatty acids, phospholipid fatty acids, and desaturase activities, expressed as precursor-to-product ratios, were not significantly affected by the intervention, although in SG the concentration of serum ferritin was correlated positively (P < .05) with Δ6-desaturase activity. Supplementing non-anemic women with low dose iron improves iron status but has no significant effect on desaturase activity. The lack of a clear effect on an indirect indicator of desaturase activity may be related to the antagonism between iron and zinc, as illustrated by the decrease in plasma zinc concentrations in women who were supplemented with iron.

Authors+Show Affiliations

Discipline of Nutrition & Metabolism, School of Molecular Bioscience, University of Sydney, Sydney, NSW 2006, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23602244

Citation

Zaman, Kamrul, et al. "Iron Supplementation Decreases Plasma Zinc but Has No Effect On Plasma Fatty Acids in Non-anemic Women." Nutrition Research (New York, N.Y.), vol. 33, no. 4, 2013, pp. 272-8.
Zaman K, McArthur JO, Abboud MN, et al. Iron supplementation decreases plasma zinc but has no effect on plasma fatty acids in non-anemic women. Nutr Res. 2013;33(4):272-8.
Zaman, K., McArthur, J. O., Abboud, M. N., Ahmad, Z. I., Garg, M. L., Petocz, P., & Samman, S. (2013). Iron supplementation decreases plasma zinc but has no effect on plasma fatty acids in non-anemic women. Nutrition Research (New York, N.Y.), 33(4), 272-8. https://doi.org/10.1016/j.nutres.2013.02.001
Zaman K, et al. Iron Supplementation Decreases Plasma Zinc but Has No Effect On Plasma Fatty Acids in Non-anemic Women. Nutr Res. 2013;33(4):272-8. PubMed PMID: 23602244.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Iron supplementation decreases plasma zinc but has no effect on plasma fatty acids in non-anemic women. AU - Zaman,Kamrul, AU - McArthur,Jennifer O, AU - Abboud,Myriam N, AU - Ahmad,Zia I, AU - Garg,Manohar L, AU - Petocz,Peter, AU - Samman,Samir, Y1 - 2013/03/09/ PY - 2012/07/09/received PY - 2012/12/22/revised PY - 2013/02/01/accepted PY - 2013/4/23/entrez PY - 2013/4/23/pubmed PY - 2014/1/1/medline SP - 272 EP - 8 JF - Nutrition research (New York, N.Y.) JO - Nutr Res VL - 33 IS - 4 N2 - Limited information is available on the role of iron in fatty acid metabolism in humans. We hypothesized that iron supplementation will increase desaturase activity, and so, the aim of this study was to determine the effect of iron supplementation on fatty acid desaturase activity in young women. Participants were randomly assigned to a control group (CG) or supplementation group (SG) who were provided with 37.4 mg of elemental iron daily for 12 weeks. Forty women completed the trial, n = 19 in CG and n = 21 in SG. The mean ages were 25.2 and 24.6 years, and body mass indices were 21.8 and 21.2 (kg/m(2)) in CG and SG, respectively. Serum ferritin concentrations increased significantly (P < .01) in subjects assigned to SG but were unchanged in CG. Serum iron concentrations were not significantly changed. Plasma zinc concentrations at the end of the intervention were similar to baseline values for individuals in CG but were decreased significantly (P = .004) in SG. Plasma fatty acids, phospholipid fatty acids, and desaturase activities, expressed as precursor-to-product ratios, were not significantly affected by the intervention, although in SG the concentration of serum ferritin was correlated positively (P < .05) with Δ6-desaturase activity. Supplementing non-anemic women with low dose iron improves iron status but has no significant effect on desaturase activity. The lack of a clear effect on an indirect indicator of desaturase activity may be related to the antagonism between iron and zinc, as illustrated by the decrease in plasma zinc concentrations in women who were supplemented with iron. SN - 1879-0739 UR - https://www.unboundmedicine.com/medline/citation/23602244/Iron_supplementation_decreases_plasma_zinc_but_has_no_effect_on_plasma_fatty_acids_in_non_anemic_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0271-5317(13)00029-8 DB - PRIME DP - Unbound Medicine ER -