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Relationship between predictors of the risk of clinical progression of benign prostatic hyperplasia and metabolic syndrome in men with moderate to severe lower urinary tract symptoms.
Urology. 2013 Jun; 81(6):1325-9.U

Abstract

OBJECTIVE

To investigate the association between the metabolic syndrome (MetS) and the predictors of the progression of benign prostatic hyperplasia (BPH).

MATERIALS AND METHODS

A total of 778 male police officers in their 50s with moderate to severe lower urinary tract symptoms (International Prostate Symptom Score > 7) were included in the present study. We defined the predictors of the risk of clinical progression of BPH as the total prostate volume ≥31 cm(3), prostate-specific antigen level ≥1.6 ng/mL, maximal flow rate <10.6 mL/s, and postvoid residual urine volume of ≥39 mL. The MetS was defined using the National Cholesterol Education Program-Adult Treatment Panel III guidelines. We used the Mantel-Haenszel extension test and logistic regression analyses to statistically examine their relationship.

RESULTS

The percentage of participants with ≥1 predictor for the progression of BPH, the percentage of participants with a total prostate volume of ≥31 cm(3), and the percentage of participants with a postvoid residual urine volume of ≥39 mL increased significantly with the increase in the number of components of the MetS (P = .003, P = .001, and P = .007, respectively). After adjusting for age and serum testosterone levels, the MetS was shown to be significantly associated with the presence ≥1 predictor for the progression of BPH (odds ratio 1.423, 95% confidence interval 1.020-1.986).

CONCLUSION

Our data have shown that the MetS is associated with the predictors of the risk of clinical progression of BPH in men in their 50s with moderate to severe lower urinary tract symptoms.

Authors+Show Affiliations

Department of Family Medicine, Yonsei University College of Medicine, Seoul, Korea.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23602796

Citation

Kwon, Hanna, et al. "Relationship Between Predictors of the Risk of Clinical Progression of Benign Prostatic Hyperplasia and Metabolic Syndrome in Men With Moderate to Severe Lower Urinary Tract Symptoms." Urology, vol. 81, no. 6, 2013, pp. 1325-9.
Kwon H, Kang HC, Lee JH. Relationship between predictors of the risk of clinical progression of benign prostatic hyperplasia and metabolic syndrome in men with moderate to severe lower urinary tract symptoms. Urology. 2013;81(6):1325-9.
Kwon, H., Kang, H. C., & Lee, J. H. (2013). Relationship between predictors of the risk of clinical progression of benign prostatic hyperplasia and metabolic syndrome in men with moderate to severe lower urinary tract symptoms. Urology, 81(6), 1325-9. https://doi.org/10.1016/j.urology.2013.01.042
Kwon H, Kang HC, Lee JH. Relationship Between Predictors of the Risk of Clinical Progression of Benign Prostatic Hyperplasia and Metabolic Syndrome in Men With Moderate to Severe Lower Urinary Tract Symptoms. Urology. 2013;81(6):1325-9. PubMed PMID: 23602796.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between predictors of the risk of clinical progression of benign prostatic hyperplasia and metabolic syndrome in men with moderate to severe lower urinary tract symptoms. AU - Kwon,Hanna, AU - Kang,Hee Cheol, AU - Lee,Jun Ho, Y1 - 2013/04/18/ PY - 2012/12/06/received PY - 2013/01/27/revised PY - 2013/01/28/accepted PY - 2013/4/23/entrez PY - 2013/4/23/pubmed PY - 2013/8/24/medline SP - 1325 EP - 9 JF - Urology JO - Urology VL - 81 IS - 6 N2 - OBJECTIVE: To investigate the association between the metabolic syndrome (MetS) and the predictors of the progression of benign prostatic hyperplasia (BPH). MATERIALS AND METHODS: A total of 778 male police officers in their 50s with moderate to severe lower urinary tract symptoms (International Prostate Symptom Score > 7) were included in the present study. We defined the predictors of the risk of clinical progression of BPH as the total prostate volume ≥31 cm(3), prostate-specific antigen level ≥1.6 ng/mL, maximal flow rate <10.6 mL/s, and postvoid residual urine volume of ≥39 mL. The MetS was defined using the National Cholesterol Education Program-Adult Treatment Panel III guidelines. We used the Mantel-Haenszel extension test and logistic regression analyses to statistically examine their relationship. RESULTS: The percentage of participants with ≥1 predictor for the progression of BPH, the percentage of participants with a total prostate volume of ≥31 cm(3), and the percentage of participants with a postvoid residual urine volume of ≥39 mL increased significantly with the increase in the number of components of the MetS (P = .003, P = .001, and P = .007, respectively). After adjusting for age and serum testosterone levels, the MetS was shown to be significantly associated with the presence ≥1 predictor for the progression of BPH (odds ratio 1.423, 95% confidence interval 1.020-1.986). CONCLUSION: Our data have shown that the MetS is associated with the predictors of the risk of clinical progression of BPH in men in their 50s with moderate to severe lower urinary tract symptoms. SN - 1527-9995 UR - https://www.unboundmedicine.com/medline/citation/23602796/Relationship_between_predictors_of_the_risk_of_clinical_progression_of_benign_prostatic_hyperplasia_and_metabolic_syndrome_in_men_with_moderate_to_severe_lower_urinary_tract_symptoms_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-4295(13)00150-7 DB - PRIME DP - Unbound Medicine ER -