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Juniperus oxycedrus L. subsp. oxycedrus and Juniperus oxycedrus L. subsp. macrocarpa (Sibth. & Sm.) Ball. "berries" from Turkey: comparative evaluation of phenolic profile, antioxidant, cytotoxic and antimicrobial activities.
Food Chem Toxicol. 2013 Aug; 58:22-9.FC

Abstract

This work aimed to evaluate and compare the phenolic profile and some biological properties of the ripe "berries" methanol extracts of Juniperus oxycedrus L. subsp. oxycedrus (Joo) and Juniperus oxycedrus L. subsp. macrocarpa (Sibth. & Sm.) Ball. (Jom) from Turkey. The total phenolic content resulted about 3-fold higher in Jom (17.89±0.23 mg GAE/g extract) than in Joo (5.14±0.06 mg GAE/g extract). The HPLC-DAD-ESI-MS analysis revealed a similar flavonoid fingerprint in Joo and Jom, whereas a difference in their quantitative content was found (4632 μg/g extract and 12644 μg/g extract). In addition, three phenolic acids were detected in Jom only (5765 μg/g extract), and protocatechuic acid was the most abundant one. The antioxidant capacity of the extracts was evaluated by different in vitro assays: in the DPPH and in the TBA tests a stronger activity in Jom was highlighted, while Joo exhibited higher reducing power and metal chelating activity. Joo and Jom did not affect HepG2 cell viability and both extracts resulted virtually non-toxic against Artemia salina. The extracts were also studied for their antimicrobial potential, displaying efficacy against Gram-positive bacteria.

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Authors+Show Affiliations

Taviano MF
Dipartimento di Scienze del Farmaco e dei Prodotti per la Salute, University of Messina, Viale Annunziata, 98168 Messina, Italy. mtaviano@unime.it
Marino A
No affiliation info available
Trovato A
No affiliation info available
Bellinghieri V
No affiliation info available
Melchini A
No affiliation info available
Dugo P
No affiliation info available
Cacciola F
No affiliation info available
Donato P
No affiliation info available
Mondello L
No affiliation info available
Güvenç A
No affiliation info available
De Pasquale R
No affiliation info available
Miceli N
No affiliation info available

MeSH

AnimalsAnti-Infective AgentsAntineoplastic AgentsAntioxidantsHep G2 CellsHumansJuniperusPhenolsPlant ExtractsSpecies Specificity

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23603383

Citation

Taviano, Maria Fernanda, et al. "Juniperus Oxycedrus L. Subsp. Oxycedrus and Juniperus Oxycedrus L. Subsp. Macrocarpa (Sibth. & Sm.) Ball. "berries" From Turkey: Comparative Evaluation of Phenolic Profile, Antioxidant, Cytotoxic and Antimicrobial Activities." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 58, 2013, pp. 22-9.
Taviano MF, Marino A, Trovato A, et al. Juniperus oxycedrus L. subsp. oxycedrus and Juniperus oxycedrus L. subsp. macrocarpa (Sibth. & Sm.) Ball. "berries" from Turkey: comparative evaluation of phenolic profile, antioxidant, cytotoxic and antimicrobial activities. Food Chem Toxicol. 2013;58:22-9.
Taviano, M. F., Marino, A., Trovato, A., Bellinghieri, V., Melchini, A., Dugo, P., Cacciola, F., Donato, P., Mondello, L., Güvenç, A., De Pasquale, R., & Miceli, N. (2013). Juniperus oxycedrus L. subsp. oxycedrus and Juniperus oxycedrus L. subsp. macrocarpa (Sibth. & Sm.) Ball. "berries" from Turkey: comparative evaluation of phenolic profile, antioxidant, cytotoxic and antimicrobial activities. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 58, 22-9. https://doi.org/10.1016/j.fct.2013.03.049
Taviano MF, et al. Juniperus Oxycedrus L. Subsp. Oxycedrus and Juniperus Oxycedrus L. Subsp. Macrocarpa (Sibth. & Sm.) Ball. "berries" From Turkey: Comparative Evaluation of Phenolic Profile, Antioxidant, Cytotoxic and Antimicrobial Activities. Food Chem Toxicol. 2013;58:22-9. PubMed PMID: 23603383.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Juniperus oxycedrus L. subsp. oxycedrus and Juniperus oxycedrus L. subsp. macrocarpa (Sibth. & Sm.) Ball. "berries" from Turkey: comparative evaluation of phenolic profile, antioxidant, cytotoxic and antimicrobial activities. AU - Taviano,Maria Fernanda, AU - Marino,Andreana, AU - Trovato,Ada, AU - Bellinghieri,Valentina, AU - Melchini,Antonietta, AU - Dugo,Paola, AU - Cacciola,Francesco, AU - Donato,Paola, AU - Mondello,Luigi, AU - Güvenç,Ayşegül, AU - De Pasquale,Rita, AU - Miceli,Natalizia, Y1 - 2013/04/18/ PY - 2012/12/07/received PY - 2013/03/15/revised PY - 2013/03/29/accepted PY - 2013/4/23/entrez PY - 2013/4/23/pubmed PY - 2014/3/7/medline KW - Antimicrobial activity KW - Antioxidant activity KW - Cytotoxic activity KW - Juniperus oxycedrus L. subsp. macrocarpa (Sibth. & Sm.) Ball. KW - Juniperus oxycedrus L. subsp. oxycedrus KW - Phenolic profile SP - 22 EP - 9 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 58 N2 - This work aimed to evaluate and compare the phenolic profile and some biological properties of the ripe "berries" methanol extracts of Juniperus oxycedrus L. subsp. oxycedrus (Joo) and Juniperus oxycedrus L. subsp. macrocarpa (Sibth. & Sm.) Ball. (Jom) from Turkey. The total phenolic content resulted about 3-fold higher in Jom (17.89±0.23 mg GAE/g extract) than in Joo (5.14±0.06 mg GAE/g extract). The HPLC-DAD-ESI-MS analysis revealed a similar flavonoid fingerprint in Joo and Jom, whereas a difference in their quantitative content was found (4632 μg/g extract and 12644 μg/g extract). In addition, three phenolic acids were detected in Jom only (5765 μg/g extract), and protocatechuic acid was the most abundant one. The antioxidant capacity of the extracts was evaluated by different in vitro assays: in the DPPH and in the TBA tests a stronger activity in Jom was highlighted, while Joo exhibited higher reducing power and metal chelating activity. Joo and Jom did not affect HepG2 cell viability and both extracts resulted virtually non-toxic against Artemia salina. The extracts were also studied for their antimicrobial potential, displaying efficacy against Gram-positive bacteria. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/23603383/Juniperus_oxycedrus_L__subsp__oxycedrus_and_Juniperus_oxycedrus_L__subsp__macrocarpa__Sibth__&_Sm___Ball__"berries"_from_Turkey:_comparative_evaluation_of_phenolic_profile_antioxidant_cytotoxic_and_antimicrobial_activities_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(13)00241-X DB - PRIME DP - Unbound Medicine ER -