Tags

Type your tag names separated by a space and hit enter

Anti-inflammatory and antimicrobial evaluation of neovestitol and vestitol isolated from Brazilian red propolis.
J Agric Food Chem. 2013 May 15; 61(19):4546-50.JA

Abstract

The objective of this study was to evaluate anti-inflammatory and antimicrobial activities of neovestitol and vestitol isolated from Brazilian red propolis (BRP). BRP ethanolic extract (EEP), neovestitol, and vestitol were evaluated by anti-inflammatory properties using a neutrophil migration assay. The antimicrobial activity was evaluated by minimal inhibitory and bactericidal concentrations (MIC and MBC) against Streptococcus mutans , Streptococcus sobrinus , Staphylococcus aureus , and Actinomyces naeslundii . Neovestitol, vestitol, and EEP inhibited neutrophil migration at a dose of 10 mg/kg. Regarding antimicrobial activity, neovestitol showed MICs ranging from <6.25 to 25-50 μg/mL and MBCs ranging from 25-50 to 50-100 μg/mL, while vestitol showed MICs ranging from 25-50 to 50-100 μg/mL and MBCs ranging from 25-50 to 50-100 μg/mL. Both isoflavonoids neovestitol and vestitol are consistent bioactive compounds displaying anti-inflammatory and antimicrobial activities that can strongly act in a low dose and concentration and have a promising potential to be applied in the pharmaceutical and food industries.

Authors+Show Affiliations

Department of Physiological Science, Piracicaba Dental School, University of Campinas (UNICAMP), C.P. 52, 13414-903 Piracicaba, São Paulo, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23607483

Citation

Bueno-Silva, Bruno, et al. "Anti-inflammatory and Antimicrobial Evaluation of Neovestitol and Vestitol Isolated From Brazilian Red Propolis." Journal of Agricultural and Food Chemistry, vol. 61, no. 19, 2013, pp. 4546-50.
Bueno-Silva B, Alencar SM, Koo H, et al. Anti-inflammatory and antimicrobial evaluation of neovestitol and vestitol isolated from Brazilian red propolis. J Agric Food Chem. 2013;61(19):4546-50.
Bueno-Silva, B., Alencar, S. M., Koo, H., Ikegaki, M., Silva, G. V., Napimoga, M. H., & Rosalen, P. L. (2013). Anti-inflammatory and antimicrobial evaluation of neovestitol and vestitol isolated from Brazilian red propolis. Journal of Agricultural and Food Chemistry, 61(19), 4546-50. https://doi.org/10.1021/jf305468f
Bueno-Silva B, et al. Anti-inflammatory and Antimicrobial Evaluation of Neovestitol and Vestitol Isolated From Brazilian Red Propolis. J Agric Food Chem. 2013 May 15;61(19):4546-50. PubMed PMID: 23607483.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory and antimicrobial evaluation of neovestitol and vestitol isolated from Brazilian red propolis. AU - Bueno-Silva,Bruno, AU - Alencar,Severino M, AU - Koo,Hyun, AU - Ikegaki,Masaharu, AU - Silva,Gil V J, AU - Napimoga,Marcelo H, AU - Rosalen,Pedro L, Y1 - 2013/05/03/ PY - 2013/4/24/entrez PY - 2013/4/24/pubmed PY - 2014/1/22/medline SP - 4546 EP - 50 JF - Journal of agricultural and food chemistry JO - J. Agric. Food Chem. VL - 61 IS - 19 N2 - The objective of this study was to evaluate anti-inflammatory and antimicrobial activities of neovestitol and vestitol isolated from Brazilian red propolis (BRP). BRP ethanolic extract (EEP), neovestitol, and vestitol were evaluated by anti-inflammatory properties using a neutrophil migration assay. The antimicrobial activity was evaluated by minimal inhibitory and bactericidal concentrations (MIC and MBC) against Streptococcus mutans , Streptococcus sobrinus , Staphylococcus aureus , and Actinomyces naeslundii . Neovestitol, vestitol, and EEP inhibited neutrophil migration at a dose of 10 mg/kg. Regarding antimicrobial activity, neovestitol showed MICs ranging from <6.25 to 25-50 μg/mL and MBCs ranging from 25-50 to 50-100 μg/mL, while vestitol showed MICs ranging from 25-50 to 50-100 μg/mL and MBCs ranging from 25-50 to 50-100 μg/mL. Both isoflavonoids neovestitol and vestitol are consistent bioactive compounds displaying anti-inflammatory and antimicrobial activities that can strongly act in a low dose and concentration and have a promising potential to be applied in the pharmaceutical and food industries. SN - 1520-5118 UR - https://www.unboundmedicine.com/medline/citation/23607483/Anti_inflammatory_and_antimicrobial_evaluation_of_neovestitol_and_vestitol_isolated_from_Brazilian_red_propolis_ L2 - https://dx.doi.org/10.1021/jf305468f DB - PRIME DP - Unbound Medicine ER -