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[Clinical observation of aripiprazole in the treatment of autism].
Zhongguo Dang Dai Er Ke Za Zhi. 2013 Apr; 15(4):294-7.ZD

Abstract

OBJECTIVE

To study the effect and safety of aripiprazole in the treatment of childhood autism.

METHODS

Thirty-five children (aged from 4 to 16 years) with autism presenting as behavioral disorders were treated with aripiprazole for 8 weeks. They were evaluated according to the Clinical Global Impression (CGI) and the Autism Treatment Evaluation Checklist (ATEC) before treatment and at the end of the 2nd, 4th and 8th weeks of treatment. Adverse reactions were observed.

RESULTS

The CGI showed illness severity decreased from the second week of aripiprazole treatment (P<0.05) and more significantly decreased illness severity was observed at the end of the 8th week (P<0.01). The curative effect score significantly increased at the end of the 8th week (P<0.05). The ATEC total scores were significantly reduced at the end of the 8th week after aripiprazole treatment. Besides the social intercourse ability, great improvements were shown in verbal communication, apperception and behavioural symptoms after aripiprazole treatment (P<0.01). Self-harm, sleep disorders and psychiatric symptoms were greatly improved after treatment and attention deficit, excessive activities, impulse to attack behavior, stereotyped behaviors and irritability were also improved to some extent. No severe adverse effects were found.

CONCLUSIONS

Aripiprazole is safe and effective for the treatment of childhood autism.

Authors+Show Affiliations

Wuhan Mental Health Center, Tongji Medical College of Huazhong University of Science & Technology, Wuhan, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

23607954

Citation

Xie, Qin, et al. "[Clinical Observation of Aripiprazole in the Treatment of Autism]." Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics, vol. 15, no. 4, 2013, pp. 294-7.
Xie Q, Tang J, Xu Y, et al. [Clinical observation of aripiprazole in the treatment of autism]. Zhongguo Dang Dai Er Ke Za Zhi. 2013;15(4):294-7.
Xie, Q., Tang, J., Xu, Y., & Zeng, H. L. (2013). [Clinical observation of aripiprazole in the treatment of autism]. Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics, 15(4), 294-7.
Xie Q, et al. [Clinical Observation of Aripiprazole in the Treatment of Autism]. Zhongguo Dang Dai Er Ke Za Zhi. 2013;15(4):294-7. PubMed PMID: 23607954.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Clinical observation of aripiprazole in the treatment of autism]. AU - Xie,Qin, AU - Tang,Jun, AU - Xu,Yang, AU - Zeng,Hong-Ling, PY - 2013/4/24/entrez PY - 2013/4/24/pubmed PY - 2013/8/9/medline SP - 294 EP - 7 JF - Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics JO - Zhongguo Dang Dai Er Ke Za Zhi VL - 15 IS - 4 N2 - OBJECTIVE: To study the effect and safety of aripiprazole in the treatment of childhood autism. METHODS: Thirty-five children (aged from 4 to 16 years) with autism presenting as behavioral disorders were treated with aripiprazole for 8 weeks. They were evaluated according to the Clinical Global Impression (CGI) and the Autism Treatment Evaluation Checklist (ATEC) before treatment and at the end of the 2nd, 4th and 8th weeks of treatment. Adverse reactions were observed. RESULTS: The CGI showed illness severity decreased from the second week of aripiprazole treatment (P<0.05) and more significantly decreased illness severity was observed at the end of the 8th week (P<0.01). The curative effect score significantly increased at the end of the 8th week (P<0.05). The ATEC total scores were significantly reduced at the end of the 8th week after aripiprazole treatment. Besides the social intercourse ability, great improvements were shown in verbal communication, apperception and behavioural symptoms after aripiprazole treatment (P<0.01). Self-harm, sleep disorders and psychiatric symptoms were greatly improved after treatment and attention deficit, excessive activities, impulse to attack behavior, stereotyped behaviors and irritability were also improved to some extent. No severe adverse effects were found. CONCLUSIONS: Aripiprazole is safe and effective for the treatment of childhood autism. SN - 1008-8830 UR - https://www.unboundmedicine.com/medline/citation/23607954/[Clinical_observation_of_aripiprazole_in_the_treatment_of_autism]_ L2 - http://www.zgddek.com/EN/abstract/abstract13049.shtml DB - PRIME DP - Unbound Medicine ER -