Tags

Type your tag names separated by a space and hit enter

Head injury and risk of Parkinson disease: a systematic review and meta-analysis.
Mov Disord 2013; 28(9):1222-9MD

Abstract

Head trauma has been implicated in the etiopathogenesis of Parkinson's disease (PD). We performed a meta-analysis to investigate the association between head trauma and the risk of developing PD. We included observational studies if they (1) clearly defined PD, (2) defined head trauma leading to concussion, and (3) presented odds ratios (ORs) and 95% confidence intervals (CIs) or provided data to compute these statistics. Random effect model was used to estimate the pooled, adjusted OR. Heterogeneity between studies was evaluated with the Q test and the I(2) statistic. We conducted a sensitivity analysis to assess the influence of each study and repeated the analysis by excluding the studies with the largest weights. We used funnel plot to assess the presence of publication bias. After reviewing more than 636 article titles, 34 articles were selected for full review. In total, 22 studies (19 case-control studies, 2 nested case-control studies, and 1 cohort study) were included in the meta-analysis. The pooled OR for the association of PD and head trauma was 1.57 (95% CI, 1.35-1.83). The results of our meta-analysis indicate that a history of head trauma that results in concussion is associated with a higher risk of developing PD. © 2013 Movement Disorder Society.

Authors+Show Affiliations

Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

23609436

Citation

Jafari, Siavash, et al. "Head Injury and Risk of Parkinson Disease: a Systematic Review and Meta-analysis." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 28, no. 9, 2013, pp. 1222-9.
Jafari S, Etminan M, Aminzadeh F, et al. Head injury and risk of Parkinson disease: a systematic review and meta-analysis. Mov Disord. 2013;28(9):1222-9.
Jafari, S., Etminan, M., Aminzadeh, F., & Samii, A. (2013). Head injury and risk of Parkinson disease: a systematic review and meta-analysis. Movement Disorders : Official Journal of the Movement Disorder Society, 28(9), pp. 1222-9. doi:10.1002/mds.25458.
Jafari S, et al. Head Injury and Risk of Parkinson Disease: a Systematic Review and Meta-analysis. Mov Disord. 2013;28(9):1222-9. PubMed PMID: 23609436.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Head injury and risk of Parkinson disease: a systematic review and meta-analysis. AU - Jafari,Siavash, AU - Etminan,Mahyar, AU - Aminzadeh,Farhad, AU - Samii,Ali, Y1 - 2013/04/22/ PY - 2011/12/20/received PY - 2013/02/26/revised PY - 2013/03/10/accepted PY - 2013/4/24/entrez PY - 2013/4/24/pubmed PY - 2014/4/3/medline KW - Parkinson's disease KW - head injury KW - head trauma KW - inflammation KW - meta-analysis KW - systematic review KW - traumatic brain injury SP - 1222 EP - 9 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov. Disord. VL - 28 IS - 9 N2 - Head trauma has been implicated in the etiopathogenesis of Parkinson's disease (PD). We performed a meta-analysis to investigate the association between head trauma and the risk of developing PD. We included observational studies if they (1) clearly defined PD, (2) defined head trauma leading to concussion, and (3) presented odds ratios (ORs) and 95% confidence intervals (CIs) or provided data to compute these statistics. Random effect model was used to estimate the pooled, adjusted OR. Heterogeneity between studies was evaluated with the Q test and the I(2) statistic. We conducted a sensitivity analysis to assess the influence of each study and repeated the analysis by excluding the studies with the largest weights. We used funnel plot to assess the presence of publication bias. After reviewing more than 636 article titles, 34 articles were selected for full review. In total, 22 studies (19 case-control studies, 2 nested case-control studies, and 1 cohort study) were included in the meta-analysis. The pooled OR for the association of PD and head trauma was 1.57 (95% CI, 1.35-1.83). The results of our meta-analysis indicate that a history of head trauma that results in concussion is associated with a higher risk of developing PD. © 2013 Movement Disorder Society. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/23609436/full_citation L2 - https://doi.org/10.1002/mds.25458 DB - PRIME DP - Unbound Medicine ER -