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Zinc supplementation alters plasma aluminum and selenium status of patients undergoing dialysis: a pilot study.
Nutrients. 2013 Apr 22; 5(4):1456-70.N

Abstract

End stage renal disease patients undergoing long-term dialysis are at risk for abnormal concentrations of certain essential and non-essential trace metals and high oxidative stress. We evaluated the effects of zinc (Zn) supplementation on plasma aluminum (Al) and selenium (Se) concentrations and oxidative stress in chronic dialysis patients. Zn-deficient patients receiving continuous ambulatory peritoneal dialysis or hemodialysis were divided into two groups according to plasma Al concentrations (HA group, Al > 50 g/L; and MA group, Al > 30 to ≤ 50 g/L). All patients received daily oral Zn supplements for two months. Age- and gender-matched healthy individuals did not receive Zn supplement. Clinical variables were assessed before, at one month, and after the supplementation period. Compared with healthy subjects, patients had significantly lower baseline plasma Se concentrations and higher oxidative stress status. After two-month Zn treatment, these patients had higher plasma Zn and Se concentrations, reduced plasma Al concentrations and oxidative stress. Furthermore, increased plasma Zn concentrations were related to the concentrations of Al, Se, oxidative product malondialdehyde (MDA), and antioxidant enzyme superoxide dismutase activities. In conclusion, Zn supplementation ameliorates abnormally high plasma Al concentrations and oxidative stress and improves Se status in long-term dialysis patients.

Authors+Show Affiliations

Micro-Nutrition & Biomedical Nutrition Labs, Institute of Biomedical Nutrition, Hung Kuang University, Taichung 433, Taiwan. hollyspirit31@yahoo.com.twNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

23609777

Citation

Guo, Chih-Hung, et al. "Zinc Supplementation Alters Plasma Aluminum and Selenium Status of Patients Undergoing Dialysis: a Pilot Study." Nutrients, vol. 5, no. 4, 2013, pp. 1456-70.
Guo CH, Chen PC, Hsu GS, et al. Zinc supplementation alters plasma aluminum and selenium status of patients undergoing dialysis: a pilot study. Nutrients. 2013;5(4):1456-70.
Guo, C. H., Chen, P. C., Hsu, G. S., & Wang, C. L. (2013). Zinc supplementation alters plasma aluminum and selenium status of patients undergoing dialysis: a pilot study. Nutrients, 5(4), 1456-70. https://doi.org/10.3390/nu5041456
Guo CH, et al. Zinc Supplementation Alters Plasma Aluminum and Selenium Status of Patients Undergoing Dialysis: a Pilot Study. Nutrients. 2013 Apr 22;5(4):1456-70. PubMed PMID: 23609777.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Zinc supplementation alters plasma aluminum and selenium status of patients undergoing dialysis: a pilot study. AU - Guo,Chih-Hung, AU - Chen,Pei-Chung, AU - Hsu,Guoo-Shyng W, AU - Wang,Chia-Liang, Y1 - 2013/04/22/ PY - 2013/02/04/received PY - 2013/03/27/revised PY - 2013/04/10/accepted PY - 2013/4/24/entrez PY - 2013/4/24/pubmed PY - 2013/7/17/medline SP - 1456 EP - 70 JF - Nutrients JO - Nutrients VL - 5 IS - 4 N2 - End stage renal disease patients undergoing long-term dialysis are at risk for abnormal concentrations of certain essential and non-essential trace metals and high oxidative stress. We evaluated the effects of zinc (Zn) supplementation on plasma aluminum (Al) and selenium (Se) concentrations and oxidative stress in chronic dialysis patients. Zn-deficient patients receiving continuous ambulatory peritoneal dialysis or hemodialysis were divided into two groups according to plasma Al concentrations (HA group, Al > 50 g/L; and MA group, Al > 30 to ≤ 50 g/L). All patients received daily oral Zn supplements for two months. Age- and gender-matched healthy individuals did not receive Zn supplement. Clinical variables were assessed before, at one month, and after the supplementation period. Compared with healthy subjects, patients had significantly lower baseline plasma Se concentrations and higher oxidative stress status. After two-month Zn treatment, these patients had higher plasma Zn and Se concentrations, reduced plasma Al concentrations and oxidative stress. Furthermore, increased plasma Zn concentrations were related to the concentrations of Al, Se, oxidative product malondialdehyde (MDA), and antioxidant enzyme superoxide dismutase activities. In conclusion, Zn supplementation ameliorates abnormally high plasma Al concentrations and oxidative stress and improves Se status in long-term dialysis patients. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/23609777/Zinc_supplementation_alters_plasma_aluminum_and_selenium_status_of_patients_undergoing_dialysis:_a_pilot_study_ L2 - https://www.mdpi.com/resolver?pii=nu5041456 DB - PRIME DP - Unbound Medicine ER -