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Atypical coupling between posterior regions of the default mode network in attention-deficit/hyperactivity disorder: a pharmaco-magnetoencephalography study.
J Psychiatry Neurosci. 2013 Sep; 38(5):333-40.JP

Abstract

BACKGROUND

Dysfunction in the default mode network (DMN), a group of cortical areas more active during the resting state, has been linked to attentional deficits and symptoms associated with attention-deficit/hyperactivity disorder (ADHD). Prior imaging studies have shown decreased functional connectivity between DMN nodes in patients with ADHD, primarily between anterior and posterior regions. Using magnetoencephalography (MEG), we evaluated phase coherence (i.e., functional connectivity) among regions of the DMN in healthy controls and adults with ADHD before and after stimulant therapy.

METHODS

We obtained a resting-state MEG recording for all participants. Magnetoencephalography data were transformed into a ~30 node regional source model using inverse spatial filtering, including regions corresponding to the DMN. We computed the zero-lag phase coherence between these regions pairwise for 5 distinct frequency bands, and we assessed group and medication effects.

RESULTS

Twelve adults with and 13 without ADHD participated in our study. Functional connectivity was stronger between particular node pairs and showed frequency-specific effects. Unmedicated patients showed reduced phase locking between posterior cingulate/precuneus regions (PCC) and right inferior parietal cortices (RIPL), and between medial prefrontal regions (MPFC) and the left inferior parietal region (LIPL) and the PCC. Unmedicated patients had increased phase locking between the RIPL and LIPL regions compared with controls. Administration of stimulants improved phase locking abnormalities along the MPFC-PCC and LIPL-RIPL pathways in patients with ADHD.

LIMITATIONS

Modest sample size and lack of duration of patient treatment history may limit the generalizability of our findings.

CONCLUSION

Adults with ADHD exhibit hyper- and hypoconnectivity between regions of the DMN during rest, which were suppressed after stimulant medication administration.

Authors+Show Affiliations

Department of Psychiatry, University of Nebraska Medical Center, Omaha, NE, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Observational Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23611175

Citation

Franzen, John D., et al. "Atypical Coupling Between Posterior Regions of the Default Mode Network in Attention-deficit/hyperactivity Disorder: a Pharmaco-magnetoencephalography Study." Journal of Psychiatry & Neuroscience : JPN, vol. 38, no. 5, 2013, pp. 333-40.
Franzen JD, Heinrichs-Graham E, White ML, et al. Atypical coupling between posterior regions of the default mode network in attention-deficit/hyperactivity disorder: a pharmaco-magnetoencephalography study. J Psychiatry Neurosci. 2013;38(5):333-40.
Franzen, J. D., Heinrichs-Graham, E., White, M. L., Wetzel, M. W., Knott, N. L., & Wilson, T. W. (2013). Atypical coupling between posterior regions of the default mode network in attention-deficit/hyperactivity disorder: a pharmaco-magnetoencephalography study. Journal of Psychiatry & Neuroscience : JPN, 38(5), 333-40. https://doi.org/10.1503/jpn.120054
Franzen JD, et al. Atypical Coupling Between Posterior Regions of the Default Mode Network in Attention-deficit/hyperactivity Disorder: a Pharmaco-magnetoencephalography Study. J Psychiatry Neurosci. 2013;38(5):333-40. PubMed PMID: 23611175.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Atypical coupling between posterior regions of the default mode network in attention-deficit/hyperactivity disorder: a pharmaco-magnetoencephalography study. AU - Franzen,John D, AU - Heinrichs-Graham,Elizabeth, AU - White,Matthew L, AU - Wetzel,Martin W, AU - Knott,Nichole L, AU - Wilson,Tony W, PY - 2013/4/25/entrez PY - 2013/4/25/pubmed PY - 2014/10/10/medline SP - 333 EP - 40 JF - Journal of psychiatry & neuroscience : JPN JO - J Psychiatry Neurosci VL - 38 IS - 5 N2 - BACKGROUND: Dysfunction in the default mode network (DMN), a group of cortical areas more active during the resting state, has been linked to attentional deficits and symptoms associated with attention-deficit/hyperactivity disorder (ADHD). Prior imaging studies have shown decreased functional connectivity between DMN nodes in patients with ADHD, primarily between anterior and posterior regions. Using magnetoencephalography (MEG), we evaluated phase coherence (i.e., functional connectivity) among regions of the DMN in healthy controls and adults with ADHD before and after stimulant therapy. METHODS: We obtained a resting-state MEG recording for all participants. Magnetoencephalography data were transformed into a ~30 node regional source model using inverse spatial filtering, including regions corresponding to the DMN. We computed the zero-lag phase coherence between these regions pairwise for 5 distinct frequency bands, and we assessed group and medication effects. RESULTS: Twelve adults with and 13 without ADHD participated in our study. Functional connectivity was stronger between particular node pairs and showed frequency-specific effects. Unmedicated patients showed reduced phase locking between posterior cingulate/precuneus regions (PCC) and right inferior parietal cortices (RIPL), and between medial prefrontal regions (MPFC) and the left inferior parietal region (LIPL) and the PCC. Unmedicated patients had increased phase locking between the RIPL and LIPL regions compared with controls. Administration of stimulants improved phase locking abnormalities along the MPFC-PCC and LIPL-RIPL pathways in patients with ADHD. LIMITATIONS: Modest sample size and lack of duration of patient treatment history may limit the generalizability of our findings. CONCLUSION: Adults with ADHD exhibit hyper- and hypoconnectivity between regions of the DMN during rest, which were suppressed after stimulant medication administration. SN - 1488-2434 UR - https://www.unboundmedicine.com/medline/citation/23611175/Atypical_coupling_between_posterior_regions_of_the_default_mode_network_in_attention_deficit/hyperactivity_disorder:_a_pharmaco_magnetoencephalography_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/10.1503/jpn.120054 DB - PRIME DP - Unbound Medicine ER -