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Effect of low-protein diet supplemented with keto acids on progression of chronic kidney disease.
J Ren Nutr. 2013 May; 23(3):210-3.JR

Abstract

Hypoproteic diets are most often discussed for patients with chronic kidney disease (CKD) who do not receive dialysis. A very low-protein diet supplemented with ketoanalogues of essential amino acids (keto-diet) proved effective in ameliorating metabolic disturbances of advanced CKD and delaying the initiation of dialysis without deleterious effects on nutritional status. Several recent studies report that the keto-diet could also slow down the rate of decline in renal function, with better outcomes after the initiation of dialysis. Results of a single-center randomized controlled trial addressing the rate of CKD progression revealed a 57% slower decline in renal function with the keto-diet compared with a conventional low-protein diet (LPD). The keto-diet allowed the safe management of selected patients with stage 4-5 CKD, delaying dialysis for almost 1 year, with a major impact on patient quality of life and health expenditures. Therefore, the keto-diet could be a link in the integrated care model. Careful selection of patients, nutritional monitoring, and dietary counseling are required.

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Authors+Show Affiliations

Garneata L
Department of Nephrology, Carol Davila University of Medicine and Pharmacy, Dr Carol Davila Teaching Hospital of Nephrology, Bucharest, Romania. lilianagarna@yahoo.com
Mircescu G
No affiliation info available

MeSH

Amino Acids, EssentialDiet, Protein-RestrictedDietary ProteinsDietary SupplementsDisease ProgressionHumansKeto AcidsNutritional StatusRandomized Controlled Trials as TopicRenal DialysisRenal Insufficiency, Chronic

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23611549

Citation

Garneata, Liliana, and Gabriel Mircescu. "Effect of Low-protein Diet Supplemented With Keto Acids On Progression of Chronic Kidney Disease." Journal of Renal Nutrition : the Official Journal of the Council On Renal Nutrition of the National Kidney Foundation, vol. 23, no. 3, 2013, pp. 210-3.
Garneata L, Mircescu G. Effect of low-protein diet supplemented with keto acids on progression of chronic kidney disease. J Ren Nutr. 2013;23(3):210-3.
Garneata, L., & Mircescu, G. (2013). Effect of low-protein diet supplemented with keto acids on progression of chronic kidney disease. Journal of Renal Nutrition : the Official Journal of the Council On Renal Nutrition of the National Kidney Foundation, 23(3), 210-3. https://doi.org/10.1053/j.jrn.2013.01.030
Garneata L, Mircescu G. Effect of Low-protein Diet Supplemented With Keto Acids On Progression of Chronic Kidney Disease. J Ren Nutr. 2013;23(3):210-3. PubMed PMID: 23611549.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of low-protein diet supplemented with keto acids on progression of chronic kidney disease. AU - Garneata,Liliana, AU - Mircescu,Gabriel, PY - 2013/01/19/received PY - 2013/01/20/accepted PY - 2013/4/25/entrez PY - 2013/4/25/pubmed PY - 2014/1/5/medline SP - 210 EP - 3 JF - Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation JO - J Ren Nutr VL - 23 IS - 3 N2 - Hypoproteic diets are most often discussed for patients with chronic kidney disease (CKD) who do not receive dialysis. A very low-protein diet supplemented with ketoanalogues of essential amino acids (keto-diet) proved effective in ameliorating metabolic disturbances of advanced CKD and delaying the initiation of dialysis without deleterious effects on nutritional status. Several recent studies report that the keto-diet could also slow down the rate of decline in renal function, with better outcomes after the initiation of dialysis. Results of a single-center randomized controlled trial addressing the rate of CKD progression revealed a 57% slower decline in renal function with the keto-diet compared with a conventional low-protein diet (LPD). The keto-diet allowed the safe management of selected patients with stage 4-5 CKD, delaying dialysis for almost 1 year, with a major impact on patient quality of life and health expenditures. Therefore, the keto-diet could be a link in the integrated care model. Careful selection of patients, nutritional monitoring, and dietary counseling are required. SN - 1532-8503 UR - https://www.unboundmedicine.com/medline/citation/23611549/Effect_of_low_protein_diet_supplemented_with_keto_acids_on_progression_of_chronic_kidney_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1051-2276(13)00056-3 DB - PRIME DP - Unbound Medicine ER -