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Comparison of resection and transarterial chemoembolisation in the treatment of advanced intrahepatic cholangiocarcinoma--a single-center experience.
Eur J Surg Oncol. 2013 Jun; 39(6):593-600.EJ

Abstract

AIMS

The aim of this study is to evaluate factors associated with the outcome after surgical resection and to compare the efficacy of surgery to transarterial chemoembolisation (TACE) in patients with advanced intrahepatic cholangiocarcinoma (IHC).

MATERIALS AND METHODS

273 patients with IHC treated in our department between 1997 and 2012 were included in our study. Patients were divided according to therapy into surgical (n = 130), TACE (n = 32), and systemic chemotherapy/best supportive care (n = 111) groups. Clinicopathological characteristics and survival were reviewed retrospectively.

RESULTS

The 1-, 3-, and 5-year survival rates in patients after surgical resection were 60%, 40%, and 23%, respectively. Recurrence occurred in 63 percent of patients after R0 resection. Median time of recurrence-free survival was 14 months. Univariate analysis revealed nine significant risk factors for overall survival in the resection group: major surgery, extrahepatic resection, vascular and bile duct resection, lymph node invasion, poor tumour differentiation, positive surgical margin, multiple lesions, tumour diameter, and UICC-Stage. Multivariate analysis showed that lymph node metastasis (P < 0.001), poor tumour differentiation (P = 0.002), and positive resection margins (P = 0.001) were independent prognostic factors for survival. Median survival as well as overall survival rates of TACE patients were comparable to those of lymph node positive patients and patients with tumour positive surgical margins.

CONCLUSIONS

R0 resection in patients with negative lymph node status remains the best chance for long-term survival in patients with IHC. There is no significant survival benefit of surgery in lymph node positive patients or patients with positive resection margin over TACE.

Authors+Show Affiliations

Department of Transplantation and Hepatobiliopancreatic Surgery, Johannes Gutenberg University, Langenbeckstrasse 1, Mainz, Germany. uwe.scheuermann@unimedizin-mainz.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

23611755

Citation

Scheuermann, U, et al. "Comparison of Resection and Transarterial Chemoembolisation in the Treatment of Advanced Intrahepatic Cholangiocarcinoma--a Single-center Experience." European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, vol. 39, no. 6, 2013, pp. 593-600.
Scheuermann U, Kaths JM, Heise M, et al. Comparison of resection and transarterial chemoembolisation in the treatment of advanced intrahepatic cholangiocarcinoma--a single-center experience. Eur J Surg Oncol. 2013;39(6):593-600.
Scheuermann, U., Kaths, J. M., Heise, M., Pitton, M. B., Weinmann, A., Hoppe-Lotichius, M., & Otto, G. (2013). Comparison of resection and transarterial chemoembolisation in the treatment of advanced intrahepatic cholangiocarcinoma--a single-center experience. European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 39(6), 593-600. https://doi.org/10.1016/j.ejso.2013.03.010
Scheuermann U, et al. Comparison of Resection and Transarterial Chemoembolisation in the Treatment of Advanced Intrahepatic Cholangiocarcinoma--a Single-center Experience. Eur J Surg Oncol. 2013;39(6):593-600. PubMed PMID: 23611755.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of resection and transarterial chemoembolisation in the treatment of advanced intrahepatic cholangiocarcinoma--a single-center experience. AU - Scheuermann,U, AU - Kaths,J M, AU - Heise,M, AU - Pitton,M B, AU - Weinmann,A, AU - Hoppe-Lotichius,M, AU - Otto,G, Y1 - 2013/04/20/ PY - 2012/10/02/received PY - 2013/03/03/revised PY - 2013/03/13/accepted PY - 2013/4/25/entrez PY - 2013/4/25/pubmed PY - 2013/7/9/medline SP - 593 EP - 600 JF - European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology JO - Eur J Surg Oncol VL - 39 IS - 6 N2 - AIMS: The aim of this study is to evaluate factors associated with the outcome after surgical resection and to compare the efficacy of surgery to transarterial chemoembolisation (TACE) in patients with advanced intrahepatic cholangiocarcinoma (IHC). MATERIALS AND METHODS: 273 patients with IHC treated in our department between 1997 and 2012 were included in our study. Patients were divided according to therapy into surgical (n = 130), TACE (n = 32), and systemic chemotherapy/best supportive care (n = 111) groups. Clinicopathological characteristics and survival were reviewed retrospectively. RESULTS: The 1-, 3-, and 5-year survival rates in patients after surgical resection were 60%, 40%, and 23%, respectively. Recurrence occurred in 63 percent of patients after R0 resection. Median time of recurrence-free survival was 14 months. Univariate analysis revealed nine significant risk factors for overall survival in the resection group: major surgery, extrahepatic resection, vascular and bile duct resection, lymph node invasion, poor tumour differentiation, positive surgical margin, multiple lesions, tumour diameter, and UICC-Stage. Multivariate analysis showed that lymph node metastasis (P < 0.001), poor tumour differentiation (P = 0.002), and positive resection margins (P = 0.001) were independent prognostic factors for survival. Median survival as well as overall survival rates of TACE patients were comparable to those of lymph node positive patients and patients with tumour positive surgical margins. CONCLUSIONS: R0 resection in patients with negative lymph node status remains the best chance for long-term survival in patients with IHC. There is no significant survival benefit of surgery in lymph node positive patients or patients with positive resection margin over TACE. SN - 1532-2157 UR - https://www.unboundmedicine.com/medline/citation/23611755/Comparison_of_resection_and_transarterial_chemoembolisation_in_the_treatment_of_advanced_intrahepatic_cholangiocarcinoma__a_single_center_experience_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0748-7983(13)00320-X DB - PRIME DP - Unbound Medicine ER -