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Correlation of thyroid fine-needle aspiration with final histopathology: a case series.
Minerva Chir. 2013 Apr; 68(2):191-7.MC

Abstract

AIM

The aim of this study was to evaluate the correlation between preoperative thyroid fine-needle aspiration result and final histopathology in patients with thyroid nodules.

METHODS

The medical records of 298 patients (mean age, 47.7±12.3 years; 79.5% females) who underwent fine-needle aspiration for thyroid nodules and who were operated and have final pathological diagnosis were retrospectively reviewed. For reporting fine-needle aspiration specimen pathology, the Bethesda thyroid fine-needle aspiration classification was used. Tyroglobulin (Tg) and anti-Tg and anti-thyroid peroxidase (anti-TPO) antibody levels were determined preoperatively.

RESULTS

Thyroid nodules were non-diagnostic, benign or atypia (Bethesda groups 1-3) in 76.8% of patients; and follicular neoplasm, suspicious for malignancy or malignant (Bethesda groups 4-6) in 23.1% of patients. Final pathology of surgery specimen was most commonly nodular goiter (36.6%) and papillary carcinoma (35.6%). Nodular goiter was significantly more prevalent in Bethesda 1 group while papillary carcinoma was more common in Bethesda 3 group (P<0.05). Tg level is significantly higher in the nodular goiter group (90.49±126.93 ng/mL), while anti-Tg and anti-TPO levels are significantly higher in the lymphocytic thyroiditis goiter group (229.77±494.42 U/mL and 282.86±360.77 U/mL, respectively) than the other pathology groups (P<0.05 for all).

CONCLUSION

Papillary carcinoma is more common in Bethesda thyroid fine-needle aspiration classification 3 group. Therefore, preoperative fine-needle aspiration for thyroid nodules is predictive of final pathology and should be applied for diagnosis and follow-up.

Authors+Show Affiliations

Department of General Surgery, Atatürk Research and Training Hospital , Ankara, Turkey. gurkandumlu@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23612233

Citation

Gürkan Dumlu, E, et al. "Correlation of Thyroid Fine-needle Aspiration With Final Histopathology: a Case Series." Minerva Chirurgica, vol. 68, no. 2, 2013, pp. 191-7.
Gürkan Dumlu E, Kiyak G, Bozkurt B, et al. Correlation of thyroid fine-needle aspiration with final histopathology: a case series. Minerva Chir. 2013;68(2):191-7.
Gürkan Dumlu, E., Kiyak, G., Bozkurt, B., Tokaç, M., Polat, B., Cakir, B., Güler, G., & Kiliç, M. (2013). Correlation of thyroid fine-needle aspiration with final histopathology: a case series. Minerva Chirurgica, 68(2), 191-7.
Gürkan Dumlu E, et al. Correlation of Thyroid Fine-needle Aspiration With Final Histopathology: a Case Series. Minerva Chir. 2013;68(2):191-7. PubMed PMID: 23612233.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation of thyroid fine-needle aspiration with final histopathology: a case series. AU - Gürkan Dumlu,E, AU - Kiyak,G, AU - Bozkurt,B, AU - Tokaç,M, AU - Polat,B, AU - Cakir,B, AU - Güler,G, AU - Kiliç,M, PY - 2013/4/25/entrez PY - 2013/4/25/pubmed PY - 2013/9/21/medline SP - 191 EP - 7 JF - Minerva chirurgica JO - Minerva Chir VL - 68 IS - 2 N2 - AIM: The aim of this study was to evaluate the correlation between preoperative thyroid fine-needle aspiration result and final histopathology in patients with thyroid nodules. METHODS: The medical records of 298 patients (mean age, 47.7±12.3 years; 79.5% females) who underwent fine-needle aspiration for thyroid nodules and who were operated and have final pathological diagnosis were retrospectively reviewed. For reporting fine-needle aspiration specimen pathology, the Bethesda thyroid fine-needle aspiration classification was used. Tyroglobulin (Tg) and anti-Tg and anti-thyroid peroxidase (anti-TPO) antibody levels were determined preoperatively. RESULTS: Thyroid nodules were non-diagnostic, benign or atypia (Bethesda groups 1-3) in 76.8% of patients; and follicular neoplasm, suspicious for malignancy or malignant (Bethesda groups 4-6) in 23.1% of patients. Final pathology of surgery specimen was most commonly nodular goiter (36.6%) and papillary carcinoma (35.6%). Nodular goiter was significantly more prevalent in Bethesda 1 group while papillary carcinoma was more common in Bethesda 3 group (P<0.05). Tg level is significantly higher in the nodular goiter group (90.49±126.93 ng/mL), while anti-Tg and anti-TPO levels are significantly higher in the lymphocytic thyroiditis goiter group (229.77±494.42 U/mL and 282.86±360.77 U/mL, respectively) than the other pathology groups (P<0.05 for all). CONCLUSION: Papillary carcinoma is more common in Bethesda thyroid fine-needle aspiration classification 3 group. Therefore, preoperative fine-needle aspiration for thyroid nodules is predictive of final pathology and should be applied for diagnosis and follow-up. SN - 0026-4733 UR - https://www.unboundmedicine.com/medline/citation/23612233/Correlation_of_thyroid_fine_needle_aspiration_with_final_histopathology:_a_case_series_ L2 - http://www.minervamedica.it/index2.t?show=R06Y2013N02A0191 DB - PRIME DP - Unbound Medicine ER -