Tags

Type your tag names separated by a space and hit enter

Alternate day fasting increases LDL particle size independently of dietary fat content in obese humans.
Eur J Clin Nutr. 2013 Jul; 67(7):783-5.EJ

Abstract

Alternate day fasting (ADF) with a low-fat (LF) diet increases low-density lipoprotein (LDL) particle size. Whether these beneficial effects can be reproduced by a high-fat (HF) ADF diet is unclear. This study compared an ADF-HF to an ADF-LF diet on plasma lipids, LDL size and high-density lipoprotein (HDL) size. Thirty-five obese subjects were randomized to an ADF-HF or ADF-LF diet for 10 weeks. Body weight decreased (P<0.0001) by 4.3±1.0 kg (4.8±1.1%) and 3.7±0.7 kg (4.2±0.8%) in the ADF-HF and ADF-LF group, respectively. LDL cholesterol was reduced (P<0.0001) by 19±8 mg/dl (18±5%) by ADF-HF and 28±7 mg/dl (25±3%) by ADF-LF. LDL particle size increased (P<0.005) by 3±1 Å in both groups. The proportion of small LDL particles decreased (P<0.005) by 8±2% and 11±3% in the ADF-HF and ADF-LF groups, respectively. HDL cholesterol and HDL size remained unchanged. Thus, our results suggest that the ADF-HF diet is equally as effective as the ADF-LF diet in improving LDL particle size and distribution.

Authors+Show Affiliations

Department of Kinesiology and Nutrition, University of Illinois, Chicago, IL, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23612508

Citation

Klempel, M C., et al. "Alternate Day Fasting Increases LDL Particle Size Independently of Dietary Fat Content in Obese Humans." European Journal of Clinical Nutrition, vol. 67, no. 7, 2013, pp. 783-5.
Klempel MC, Kroeger CM, Varady KA. Alternate day fasting increases LDL particle size independently of dietary fat content in obese humans. Eur J Clin Nutr. 2013;67(7):783-5.
Klempel, M. C., Kroeger, C. M., & Varady, K. A. (2013). Alternate day fasting increases LDL particle size independently of dietary fat content in obese humans. European Journal of Clinical Nutrition, 67(7), 783-5. https://doi.org/10.1038/ejcn.2013.83
Klempel MC, Kroeger CM, Varady KA. Alternate Day Fasting Increases LDL Particle Size Independently of Dietary Fat Content in Obese Humans. Eur J Clin Nutr. 2013;67(7):783-5. PubMed PMID: 23612508.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alternate day fasting increases LDL particle size independently of dietary fat content in obese humans. AU - Klempel,M C, AU - Kroeger,C M, AU - Varady,K A, Y1 - 2013/04/24/ PY - 2012/12/12/received PY - 2013/03/21/revised PY - 2013/03/25/accepted PY - 2013/4/25/entrez PY - 2013/4/25/pubmed PY - 2014/2/7/medline SP - 783 EP - 5 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 67 IS - 7 N2 - Alternate day fasting (ADF) with a low-fat (LF) diet increases low-density lipoprotein (LDL) particle size. Whether these beneficial effects can be reproduced by a high-fat (HF) ADF diet is unclear. This study compared an ADF-HF to an ADF-LF diet on plasma lipids, LDL size and high-density lipoprotein (HDL) size. Thirty-five obese subjects were randomized to an ADF-HF or ADF-LF diet for 10 weeks. Body weight decreased (P<0.0001) by 4.3±1.0 kg (4.8±1.1%) and 3.7±0.7 kg (4.2±0.8%) in the ADF-HF and ADF-LF group, respectively. LDL cholesterol was reduced (P<0.0001) by 19±8 mg/dl (18±5%) by ADF-HF and 28±7 mg/dl (25±3%) by ADF-LF. LDL particle size increased (P<0.005) by 3±1 Å in both groups. The proportion of small LDL particles decreased (P<0.005) by 8±2% and 11±3% in the ADF-HF and ADF-LF groups, respectively. HDL cholesterol and HDL size remained unchanged. Thus, our results suggest that the ADF-HF diet is equally as effective as the ADF-LF diet in improving LDL particle size and distribution. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/23612508/Alternate_day_fasting_increases_LDL_particle_size_independently_of_dietary_fat_content_in_obese_humans_ L2 - https://doi.org/10.1038/ejcn.2013.83 DB - PRIME DP - Unbound Medicine ER -