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Biochemical and histological changes in rat liver caused by cypermethrin and beta-cyfluthrin.
Arh Hig Rada Toksikol. 2013; 64(1):57-67.AH

Abstract

Cypermethrin and beta-cyfluthrin are two most widely used multipurpose pyrethroids. After determining their oral LD50 (416.98 mg kg-1 and 354.8 mg kg-1 body weight, respectively), we assessed their hepatotoxicity in Wistar rats following acute (0.1 LD50 for 1 day) and sub-acute (0.1 LD50 for 7, 14, 21 or 28 days) poisoning. The assessment was based on hepatic marker enzymes AST, ALT, LDH, ALP, glycogen, total proteins, total lipids, cholesterol, free fatty acids, and phospholipids. AST, ALT, LDH, total lipids, cholesterol, phospholipids, and free fatty acids in hepatic homogenate increased following pyrethroid stress. In contrast, hepatic proteins, glycogen, and ALP activity decreased due to lysis of structural proteins and leakage of enzymes into the blood stream. Biochemical data were consistent with histological alterations (cytoplasmic vacuolisation, nuclear polymorphism, eccentric nucleus, karyolysis, karyorrhexis, and sinusoidal dilation). Comparatively greater hepatocellular damage was noted in beta-cyfluthrin than in cypermethrin-treated rats, which is probably related to the fluorine atom in beta-cyfluthrin.

Authors+Show Affiliations

Toxicology Laboratory, Department of Zoology, School of Life Sciences, Dr Bhim Rao Ambedkar University, Khandari Campus, Agra, India. bantu.sls@gmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23612525

Citation

Bhushan, Brijender, et al. "Biochemical and Histological Changes in Rat Liver Caused By Cypermethrin and Beta-cyfluthrin." Arhiv Za Higijenu Rada I Toksikologiju, vol. 64, no. 1, 2013, pp. 57-67.
Bhushan B, Saxena PN, Saxena N. Biochemical and histological changes in rat liver caused by cypermethrin and beta-cyfluthrin. Arh Hig Rada Toksikol. 2013;64(1):57-67.
Bhushan, B., Saxena, P. N., & Saxena, N. (2013). Biochemical and histological changes in rat liver caused by cypermethrin and beta-cyfluthrin. Arhiv Za Higijenu Rada I Toksikologiju, 64(1), 57-67. https://doi.org/10.2478/10004-1254-64-2013-2184
Bhushan B, Saxena PN, Saxena N. Biochemical and Histological Changes in Rat Liver Caused By Cypermethrin and Beta-cyfluthrin. Arh Hig Rada Toksikol. 2013;64(1):57-67. PubMed PMID: 23612525.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biochemical and histological changes in rat liver caused by cypermethrin and beta-cyfluthrin. AU - Bhushan,Brijender, AU - Saxena,Prabhu N, AU - Saxena,Nishi, PY - 2013/4/25/entrez PY - 2013/4/25/pubmed PY - 2015/4/14/medline SP - 57 EP - 67 JF - Arhiv za higijenu rada i toksikologiju JO - Arh Hig Rada Toksikol VL - 64 IS - 1 N2 - Cypermethrin and beta-cyfluthrin are two most widely used multipurpose pyrethroids. After determining their oral LD50 (416.98 mg kg-1 and 354.8 mg kg-1 body weight, respectively), we assessed their hepatotoxicity in Wistar rats following acute (0.1 LD50 for 1 day) and sub-acute (0.1 LD50 for 7, 14, 21 or 28 days) poisoning. The assessment was based on hepatic marker enzymes AST, ALT, LDH, ALP, glycogen, total proteins, total lipids, cholesterol, free fatty acids, and phospholipids. AST, ALT, LDH, total lipids, cholesterol, phospholipids, and free fatty acids in hepatic homogenate increased following pyrethroid stress. In contrast, hepatic proteins, glycogen, and ALP activity decreased due to lysis of structural proteins and leakage of enzymes into the blood stream. Biochemical data were consistent with histological alterations (cytoplasmic vacuolisation, nuclear polymorphism, eccentric nucleus, karyolysis, karyorrhexis, and sinusoidal dilation). Comparatively greater hepatocellular damage was noted in beta-cyfluthrin than in cypermethrin-treated rats, which is probably related to the fluorine atom in beta-cyfluthrin. SN - 1848-6312 UR - https://www.unboundmedicine.com/medline/citation/23612525/Biochemical_and_histological_changes_in_rat_liver_caused_by_cypermethrin_and_beta_cyfluthrin_ L2 - https://www.degruyter.com/doi/10.2478/10004-1254-64-2013-2184 DB - PRIME DP - Unbound Medicine ER -