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Blood 25-hydroxy vitamin D levels and incident type 2 diabetes: a meta-analysis of prospective studies.
Diabetes Care. 2013 May; 36(5):1422-8.DC

Abstract

OBJECTIVE

To quantitatively assess the strength and shape of the association between blood 25-hydroxy vitamin D [25(OH)D] levels and incident risk of type 2 diabetes.

RESEARCH DESIGN AND METHODS

A systematic search of the MEDLINE and Embase databases and a hand search of references from original reports were conducted up to 31 October 2012. Prospective observational studies that assessed the association between blood levels of 25(OH)D and risk of incident type 2 diabetes were included for meta-analysis. DerSimonian and Laird's random-effects model was used. A quadratic spline regression analysis was used to examine the shape of the association with a generalized least-squares trend test performed for the dose-response relation.

RESULTS

A total of 21 prospective studies involving 76,220 participants and 4,996 incident type 2 diabetes cases were included for meta-analysis. Comparing the highest to the lowest category of 25(OH)D levels, the summary relative risk for type 2 diabetes was 0.62 (95% CI 0.54-0.70). A spline regression model showed that higher 25(OH)D levels were monotonically associated with a lower diabetes risk. This inverse association did not differ by sex, duration of follow-up, study sample size, diabetes diagnostic criteria, or 25(OH)D assay method. A linear trend analysis showed that each 10 nmol/L increment in 25(OH)D levels was associated with a 4% lower risk of type 2 diabetes (95% CI 3-6; P for linear trend < 0.0001).

CONCLUSIONS

Our meta-analysis showed an inverse and significant association between circulating 25(OH)D levels and risk of type 2 diabetes across a broad range of blood 25(OH)D levels in diverse populations.

Authors+Show Affiliations

Department of Medicine, Harvard Medical School, Boston, MA, USA. ysong3@rics.bwh.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

23613602

Citation

Song, Yiqing, et al. "Blood 25-hydroxy Vitamin D Levels and Incident Type 2 Diabetes: a Meta-analysis of Prospective Studies." Diabetes Care, vol. 36, no. 5, 2013, pp. 1422-8.
Song Y, Wang L, Pittas AG, et al. Blood 25-hydroxy vitamin D levels and incident type 2 diabetes: a meta-analysis of prospective studies. Diabetes Care. 2013;36(5):1422-8.
Song, Y., Wang, L., Pittas, A. G., Del Gobbo, L. C., Zhang, C., Manson, J. E., & Hu, F. B. (2013). Blood 25-hydroxy vitamin D levels and incident type 2 diabetes: a meta-analysis of prospective studies. Diabetes Care, 36(5), 1422-8. https://doi.org/10.2337/dc12-0962
Song Y, et al. Blood 25-hydroxy Vitamin D Levels and Incident Type 2 Diabetes: a Meta-analysis of Prospective Studies. Diabetes Care. 2013;36(5):1422-8. PubMed PMID: 23613602.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Blood 25-hydroxy vitamin D levels and incident type 2 diabetes: a meta-analysis of prospective studies. AU - Song,Yiqing, AU - Wang,Lu, AU - Pittas,Anastassios G, AU - Del Gobbo,Liana C, AU - Zhang,Cuilin, AU - Manson,Joann E, AU - Hu,Frank B, PY - 2013/4/25/entrez PY - 2013/4/25/pubmed PY - 2013/12/16/medline SP - 1422 EP - 8 JF - Diabetes care JO - Diabetes Care VL - 36 IS - 5 N2 - OBJECTIVE: To quantitatively assess the strength and shape of the association between blood 25-hydroxy vitamin D [25(OH)D] levels and incident risk of type 2 diabetes. RESEARCH DESIGN AND METHODS: A systematic search of the MEDLINE and Embase databases and a hand search of references from original reports were conducted up to 31 October 2012. Prospective observational studies that assessed the association between blood levels of 25(OH)D and risk of incident type 2 diabetes were included for meta-analysis. DerSimonian and Laird's random-effects model was used. A quadratic spline regression analysis was used to examine the shape of the association with a generalized least-squares trend test performed for the dose-response relation. RESULTS: A total of 21 prospective studies involving 76,220 participants and 4,996 incident type 2 diabetes cases were included for meta-analysis. Comparing the highest to the lowest category of 25(OH)D levels, the summary relative risk for type 2 diabetes was 0.62 (95% CI 0.54-0.70). A spline regression model showed that higher 25(OH)D levels were monotonically associated with a lower diabetes risk. This inverse association did not differ by sex, duration of follow-up, study sample size, diabetes diagnostic criteria, or 25(OH)D assay method. A linear trend analysis showed that each 10 nmol/L increment in 25(OH)D levels was associated with a 4% lower risk of type 2 diabetes (95% CI 3-6; P for linear trend < 0.0001). CONCLUSIONS: Our meta-analysis showed an inverse and significant association between circulating 25(OH)D levels and risk of type 2 diabetes across a broad range of blood 25(OH)D levels in diverse populations. SN - 1935-5548 UR - https://www.unboundmedicine.com/medline/citation/23613602/Blood_25_hydroxy_vitamin_D_levels_and_incident_type_2_diabetes:_a_meta_analysis_of_prospective_studies_ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&amp;pmid=23613602 DB - PRIME DP - Unbound Medicine ER -