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Assessment of xanthan gum based sustained release matrix tablets containing highly water-soluble propranolol HCl.
Acta Pol Pharm. 2013 Mar-Apr; 70(2):283-9.AP

Abstract

The present study was carried out to develop oral sustained release tablets of propranolol HCl by different ratios of drug : matrix. Tablets were prepared by direct compression technique using xanthan gum and lactose. All the formulations (tablets) were evaluated for thickness, diameter, hardness, friability, weight variation, content of active ingredient, in vitro dissolution using USP dissolution apparatus-II and swelling index. In case of dissolution, an inverse relationship was noted between amount of xanthan gum and release rate of propranolol HCl and the drug release was gradually enhanced as the amount of the lactose increased. The direct release was observed between swelling index and xanthan gum concentration. Significant difference in different media was observed in release profile, indicating that propranolol HCI has better solubility in HCI buffer pH 1.2. Moreover, dissolution data at differing stirring speeds was also analyzed, indicating that the drug release profile was at 50 rpm comparative to 100 rpm. The kinetic treatment showed the best fitted different mathematical models (zero order, first order, Higuchi's, Hixson-Crowell and Korsmeyer Peppas model. Most of the formulations showed linearity in Higuchi's model. The drug release from these tablets was by Fickian diffusion and anomalous (non-Fickian) mechanisms.

Authors+Show Affiliations

Department of Pharmacy, Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Pakistan. ajmaline2000@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23614284

Citation

Ali, Atif, et al. "Assessment of Xanthan Gum Based Sustained Release Matrix Tablets Containing Highly Water-soluble Propranolol HCl." Acta Poloniae Pharmaceutica, vol. 70, no. 2, 2013, pp. 283-9.
Ali A, Iqbal M, Akhtar N, et al. Assessment of xanthan gum based sustained release matrix tablets containing highly water-soluble propranolol HCl. Acta Pol Pharm. 2013;70(2):283-9.
Ali, A., Iqbal, M., Akhtar, N., Khan, H. M., Ullah, A., Uddin, M., & Khan, M. T. (2013). Assessment of xanthan gum based sustained release matrix tablets containing highly water-soluble propranolol HCl. Acta Poloniae Pharmaceutica, 70(2), 283-9.
Ali A, et al. Assessment of Xanthan Gum Based Sustained Release Matrix Tablets Containing Highly Water-soluble Propranolol HCl. Acta Pol Pharm. 2013 Mar-Apr;70(2):283-9. PubMed PMID: 23614284.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessment of xanthan gum based sustained release matrix tablets containing highly water-soluble propranolol HCl. AU - Ali,Atif, AU - Iqbal,Muhammad, AU - Akhtar,Naveed, AU - Khan,Haji Muhamad Shoaib, AU - Ullah,Aftab, AU - Uddin,Minhaj, AU - Khan,Muhammad Tahir, PY - 2013/4/26/entrez PY - 2013/4/26/pubmed PY - 2013/6/19/medline SP - 283 EP - 9 JF - Acta poloniae pharmaceutica JO - Acta Pol Pharm VL - 70 IS - 2 N2 - The present study was carried out to develop oral sustained release tablets of propranolol HCl by different ratios of drug : matrix. Tablets were prepared by direct compression technique using xanthan gum and lactose. All the formulations (tablets) were evaluated for thickness, diameter, hardness, friability, weight variation, content of active ingredient, in vitro dissolution using USP dissolution apparatus-II and swelling index. In case of dissolution, an inverse relationship was noted between amount of xanthan gum and release rate of propranolol HCl and the drug release was gradually enhanced as the amount of the lactose increased. The direct release was observed between swelling index and xanthan gum concentration. Significant difference in different media was observed in release profile, indicating that propranolol HCI has better solubility in HCI buffer pH 1.2. Moreover, dissolution data at differing stirring speeds was also analyzed, indicating that the drug release profile was at 50 rpm comparative to 100 rpm. The kinetic treatment showed the best fitted different mathematical models (zero order, first order, Higuchi's, Hixson-Crowell and Korsmeyer Peppas model. Most of the formulations showed linearity in Higuchi's model. The drug release from these tablets was by Fickian diffusion and anomalous (non-Fickian) mechanisms. SN - 0001-6837 UR - https://www.unboundmedicine.com/medline/citation/23614284/Assessment_of_xanthan_gum_based_sustained_release_matrix_tablets_containing_highly_water_soluble_propranolol_HCl_ L2 - http://www.ptfarm.pl/pub/File/Acta_Poloniae/2013/2/283.pdf DB - PRIME DP - Unbound Medicine ER -