Tags

Type your tag names separated by a space and hit enter

Inulin-based tablet in capsule device for variable multipulse delivery of aceclofenac: optimization and in vivo roentgenography.
AAPS PharmSciTech. 2013 Jun; 14(2):736-47.AP

Abstract

The aim of the study was to develop single-unit tablet in capsule system of aceclofenac for the treatment of late night pain and morning stiffness associated with rheumatoid arthritis. The system was conceptualized as a three-component design (1) a hard gelatin enteric-coated capsule (for carrying two pulses), (2) first-pulse granules (for rapid release in intestine), and (2) second-pulse matrix tablet (for slow release in colon). An appropriate integration of pH-sensitive (Eudragit S100) and bacteria-responsive (inulin) functions, on the basis of 3(2) factorial design, led to formulation of TICS 1-9 that were screened for in vitro release. TICS 2 with biphasic drug release of 98.64% from first-pulse granules in simulated intestinal fluid (12 h) and 97.82% from second-pulse matrix tablet in simulated colonic fluid (24 h) was the optimized formulation that exhibited Fickian diffusion of drug (n=0.363). In vivo fluoroscopy in rats traced the intact tablet to colon in 7.5 h that got eroded at the tenth hour. This demonstrated the colon-specific delivery of the matrix tablet affirming the potential of the system to obviate the need for two-time administration of drug at odd hours. The experimental design was validated by extra design check point, and diffuse reflectance spectroscopy and DSC revealed absence of chemical interaction between the formulation excipients.

Authors+Show Affiliations

Department of Pharmaceutics, Rajiv Academy for Pharmacy, P.O. Chattikara, Mathura 281001, Uttar Pradesh, India.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23615771

Citation

Sharma, Puja, and Kamla Pathak. "Inulin-based Tablet in Capsule Device for Variable Multipulse Delivery of Aceclofenac: Optimization and in Vivo Roentgenography." AAPS PharmSciTech, vol. 14, no. 2, 2013, pp. 736-47.
Sharma P, Pathak K. Inulin-based tablet in capsule device for variable multipulse delivery of aceclofenac: optimization and in vivo roentgenography. AAPS PharmSciTech. 2013;14(2):736-47.
Sharma, P., & Pathak, K. (2013). Inulin-based tablet in capsule device for variable multipulse delivery of aceclofenac: optimization and in vivo roentgenography. AAPS PharmSciTech, 14(2), 736-47. https://doi.org/10.1208/s12249-013-9959-8
Sharma P, Pathak K. Inulin-based Tablet in Capsule Device for Variable Multipulse Delivery of Aceclofenac: Optimization and in Vivo Roentgenography. AAPS PharmSciTech. 2013;14(2):736-47. PubMed PMID: 23615771.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inulin-based tablet in capsule device for variable multipulse delivery of aceclofenac: optimization and in vivo roentgenography. AU - Sharma,Puja, AU - Pathak,Kamla, Y1 - 2013/04/25/ PY - 2013/01/04/received PY - 2013/03/14/accepted PY - 2013/4/26/entrez PY - 2013/4/26/pubmed PY - 2013/10/18/medline SP - 736 EP - 47 JF - AAPS PharmSciTech JO - AAPS PharmSciTech VL - 14 IS - 2 N2 - The aim of the study was to develop single-unit tablet in capsule system of aceclofenac for the treatment of late night pain and morning stiffness associated with rheumatoid arthritis. The system was conceptualized as a three-component design (1) a hard gelatin enteric-coated capsule (for carrying two pulses), (2) first-pulse granules (for rapid release in intestine), and (2) second-pulse matrix tablet (for slow release in colon). An appropriate integration of pH-sensitive (Eudragit S100) and bacteria-responsive (inulin) functions, on the basis of 3(2) factorial design, led to formulation of TICS 1-9 that were screened for in vitro release. TICS 2 with biphasic drug release of 98.64% from first-pulse granules in simulated intestinal fluid (12 h) and 97.82% from second-pulse matrix tablet in simulated colonic fluid (24 h) was the optimized formulation that exhibited Fickian diffusion of drug (n=0.363). In vivo fluoroscopy in rats traced the intact tablet to colon in 7.5 h that got eroded at the tenth hour. This demonstrated the colon-specific delivery of the matrix tablet affirming the potential of the system to obviate the need for two-time administration of drug at odd hours. The experimental design was validated by extra design check point, and diffuse reflectance spectroscopy and DSC revealed absence of chemical interaction between the formulation excipients. SN - 1530-9932 UR - https://www.unboundmedicine.com/medline/citation/23615771/Inulin_based_tablet_in_capsule_device_for_variable_multipulse_delivery_of_aceclofenac:_optimization_and_in_vivo_roentgenography_ L2 - https://dx.doi.org/10.1208/s12249-013-9959-8 DB - PRIME DP - Unbound Medicine ER -