Tags

Type your tag names separated by a space and hit enter

Eicosapentaenoic acid in serum phospholipids relates to a less atherogenic lipoprotein profile in subjects with familial hypercholesterolemia.
J Nutr Biochem. 2013 Sep; 24(9):1604-8.JN

Abstract

Familial hypercholesterolemia (FH) carries an increased vascular risk due to lifelong elevation of the number of circulating low-density lipoprotein (LDL) particles, but also to alterations in triglyceride and high-density lipoprotein (HDL) metabolism. Supplementation with eicosapentaenoic (EPA) or docosahexaenoic (DHA) acids reduced LDL particle number and/or increased LDL size in different populations, but studies in FH are scarce. We investigated cross-sectionally whether intake of EPA and DHA in the usual diet is associated with a less atherogenic lipoprotein profile in subjects with FH (n=215). Lipoprotein particle number and size distributions were assessed with nuclear magnetic resonance spectroscopy. EPA and DHA proportions in serum phosphatidylcholine, a biomarker of fish intake, were determined by gas chromatography. After adjusting for cardiovascular risk factors, including fasting triglycerides, serum phosphatidylcholine EPA (but not DHA) related inversely to medium VLDL, total LDL particle number and very small LDL, resulting in a net direct association with LDL size. Additionally, EPA was directly associated with concentrations of large HDL. We conclude that increased serum phosphatidylcholine EPA derived from seafood intake with the usual diet is associated with a less atherogenic lipoprotein profile in subjects with FH. Increased fish intake and/or EPA supplements might contribute to reduce the residual risk of statin-treated FH subjects.

Authors+Show Affiliations

Unitat de Lípids, Servei d'Endocrinologia i Nutrició, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Barcelona, Spain. asala@clinic.ub.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23618530

Citation

Sala-Vila, Aleix, et al. "Eicosapentaenoic Acid in Serum Phospholipids Relates to a Less Atherogenic Lipoprotein Profile in Subjects With Familial Hypercholesterolemia." The Journal of Nutritional Biochemistry, vol. 24, no. 9, 2013, pp. 1604-8.
Sala-Vila A, Cofán M, Mateo-Gallego R, et al. Eicosapentaenoic acid in serum phospholipids relates to a less atherogenic lipoprotein profile in subjects with familial hypercholesterolemia. J Nutr Biochem. 2013;24(9):1604-8.
Sala-Vila, A., Cofán, M., Mateo-Gallego, R., Cenarro, A., Civeira, F., & Ros, E. (2013). Eicosapentaenoic acid in serum phospholipids relates to a less atherogenic lipoprotein profile in subjects with familial hypercholesterolemia. The Journal of Nutritional Biochemistry, 24(9), 1604-8. https://doi.org/10.1016/j.jnutbio.2013.01.011
Sala-Vila A, et al. Eicosapentaenoic Acid in Serum Phospholipids Relates to a Less Atherogenic Lipoprotein Profile in Subjects With Familial Hypercholesterolemia. J Nutr Biochem. 2013;24(9):1604-8. PubMed PMID: 23618530.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Eicosapentaenoic acid in serum phospholipids relates to a less atherogenic lipoprotein profile in subjects with familial hypercholesterolemia. AU - Sala-Vila,Aleix, AU - Cofán,Montserrat, AU - Mateo-Gallego,Rocío, AU - Cenarro,Ana, AU - Civeira,Fernando, AU - Ros,Emilio, Y1 - 2013/04/22/ PY - 2012/09/03/received PY - 2013/01/11/revised PY - 2013/01/16/accepted PY - 2013/4/27/entrez PY - 2013/4/27/pubmed PY - 2014/3/4/medline KW - Docosahexaenoic acid KW - Eicosapentaenoic acid KW - Familial hypercholesterolemia KW - Lipoprotein subfractions KW - Long-chain n-3 polyunsaturated fatty acids SP - 1604 EP - 8 JF - The Journal of nutritional biochemistry JO - J Nutr Biochem VL - 24 IS - 9 N2 - Familial hypercholesterolemia (FH) carries an increased vascular risk due to lifelong elevation of the number of circulating low-density lipoprotein (LDL) particles, but also to alterations in triglyceride and high-density lipoprotein (HDL) metabolism. Supplementation with eicosapentaenoic (EPA) or docosahexaenoic (DHA) acids reduced LDL particle number and/or increased LDL size in different populations, but studies in FH are scarce. We investigated cross-sectionally whether intake of EPA and DHA in the usual diet is associated with a less atherogenic lipoprotein profile in subjects with FH (n=215). Lipoprotein particle number and size distributions were assessed with nuclear magnetic resonance spectroscopy. EPA and DHA proportions in serum phosphatidylcholine, a biomarker of fish intake, were determined by gas chromatography. After adjusting for cardiovascular risk factors, including fasting triglycerides, serum phosphatidylcholine EPA (but not DHA) related inversely to medium VLDL, total LDL particle number and very small LDL, resulting in a net direct association with LDL size. Additionally, EPA was directly associated with concentrations of large HDL. We conclude that increased serum phosphatidylcholine EPA derived from seafood intake with the usual diet is associated with a less atherogenic lipoprotein profile in subjects with FH. Increased fish intake and/or EPA supplements might contribute to reduce the residual risk of statin-treated FH subjects. SN - 1873-4847 UR - https://www.unboundmedicine.com/medline/citation/23618530/Eicosapentaenoic_acid_in_serum_phospholipids_relates_to_a_less_atherogenic_lipoprotein_profile_in_subjects_with_familial_hypercholesterolemia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0955-2863(13)00035-1 DB - PRIME DP - Unbound Medicine ER -