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Hormone therapy in acne.
Indian J Dermatol Venereol Leprol. 2013 May-Jun; 79(3):322-37.IJ

Abstract

Underlying hormone imbalances may render acne unresponsive to conventional therapy. Relevant investigations followed by initiation of hormonal therapy in combination with regular anti-acne therapy may be necessary if signs of hyperandrogenism are present. In addition to other factors, androgen-stimulated sebum production plays an important role in the pathophysiology of acne in women. Sebum production is also regulated by other hormones, including estrogens, growth hormone, insulin, insulin-like growth factor-1, glucocorticoids, adrenocorticotropic hormone, and melanocortins. Hormonal therapy may also be beneficial in female acne patients with normal serum androgen levels. An understanding of the sebaceous gland and the hormonal influences in the pathogenesis of acne would be essential for optimizing hormonal therapy. Sebocytes form the sebaceous gland. Human sebocytes express a multitude of receptors, including receptors for peptide hormones, neurotransmitters and the receptors for steroid and thyroid hormones. Various hormones and mediators acting through the sebocyte receptors play a role in the orchestration of pathogenetic lesions of acne. Thus, the goal of hormonal treatment is a reduction in sebum production. This review shall focus on hormonal influences in the elicitation of acne via the sebocyte receptors, pathways of cutaneous androgen metabolism, various clinical scenarios and syndromes associated with acne, and the available therapeutic armamentarium of hormones and drugs having hormone-like actions in the treatment of acne.

Authors+Show Affiliations

Department of Dermatology, PSG Hospitals and PSGIMSR, Coimbatore, Tamil Nadu, India.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23619437

Citation

Lakshmi, Chembolli. "Hormone Therapy in Acne." Indian Journal of Dermatology, Venereology and Leprology, vol. 79, no. 3, 2013, pp. 322-37.
Lakshmi C. Hormone therapy in acne. Indian J Dermatol Venereol Leprol. 2013;79(3):322-37.
Lakshmi, C. (2013). Hormone therapy in acne. Indian Journal of Dermatology, Venereology and Leprology, 79(3), 322-37. https://doi.org/10.4103/0378-6323.110765
Lakshmi C. Hormone Therapy in Acne. Indian J Dermatol Venereol Leprol. 2013;79(3):322-37. PubMed PMID: 23619437.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hormone therapy in acne. A1 - Lakshmi,Chembolli, PY - 2013/4/27/entrez PY - 2013/4/27/pubmed PY - 2013/12/16/medline SP - 322 EP - 37 JF - Indian journal of dermatology, venereology and leprology JO - Indian J Dermatol Venereol Leprol VL - 79 IS - 3 N2 - Underlying hormone imbalances may render acne unresponsive to conventional therapy. Relevant investigations followed by initiation of hormonal therapy in combination with regular anti-acne therapy may be necessary if signs of hyperandrogenism are present. In addition to other factors, androgen-stimulated sebum production plays an important role in the pathophysiology of acne in women. Sebum production is also regulated by other hormones, including estrogens, growth hormone, insulin, insulin-like growth factor-1, glucocorticoids, adrenocorticotropic hormone, and melanocortins. Hormonal therapy may also be beneficial in female acne patients with normal serum androgen levels. An understanding of the sebaceous gland and the hormonal influences in the pathogenesis of acne would be essential for optimizing hormonal therapy. Sebocytes form the sebaceous gland. Human sebocytes express a multitude of receptors, including receptors for peptide hormones, neurotransmitters and the receptors for steroid and thyroid hormones. Various hormones and mediators acting through the sebocyte receptors play a role in the orchestration of pathogenetic lesions of acne. Thus, the goal of hormonal treatment is a reduction in sebum production. This review shall focus on hormonal influences in the elicitation of acne via the sebocyte receptors, pathways of cutaneous androgen metabolism, various clinical scenarios and syndromes associated with acne, and the available therapeutic armamentarium of hormones and drugs having hormone-like actions in the treatment of acne. SN - 0973-3922 UR - https://www.unboundmedicine.com/medline/citation/23619437/Hormone_therapy_in_acne_ L2 - http://www.ijdvl.com/article.asp?issn=0378-6323;year=2013;volume=79;issue=3;spage=322;epage=337;aulast=Lakshmi DB - PRIME DP - Unbound Medicine ER -