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The epidemiology of pancreatitis and pancreatic cancer.

Abstract

Acute pancreatitis is one of the most frequent gastrointestinal causes of hospital admission in the United States. Chronic pancreatitis, although lower in incidence, significantly reduces patients' quality of life. Pancreatic cancer is associated with a high mortality rate and is one of the top 5 causes of death from cancer. The burden of pancreatic disorders is expected to increase over time. The risk and etiology of pancreatitis differ with age and sex, and all pancreatic disorders affect the black population more than any other race. Gallstones are the most common cause of acute pancreatitis, and early cholecystectomy eliminates the risk of future attacks. Alcohol continues to be the single most important risk factor for chronic pancreatitis. Smoking is an independent risk factor for acute and chronic pancreatitis, and its effects could synergize with those of alcohol. Significant risk factors for pancreatic cancer include smoking and non-O blood groups. Alcohol abstinence and smoking cessation can alter the progression of pancreatitis and reduce recurrence; smoking cessation is the most effective strategy to reduce the risk of pancreatic cancer.

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  • Authors+Show Affiliations

    ,

    Division of Gastroenterology & Hepatology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA. yadavd@upmc.edu

    Source

    Gastroenterology 144:6 2013 Jun pg 1252-61

    MeSH

    Adult
    Age Factors
    Aged
    Alcohol Drinking
    Continental Population Groups
    Female
    Humans
    Incidence
    Male
    Middle Aged
    Pancreatic Neoplasms
    Pancreatitis
    Pancreatitis, Alcoholic
    Prevalence
    Prognosis
    Risk Factors
    Risk Reduction Behavior
    Sex Factors
    Smoking
    Time Factors

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Review

    Language

    eng

    PubMed ID

    23622135

    Citation

    Yadav, Dhiraj, and Albert B. Lowenfels. "The Epidemiology of Pancreatitis and Pancreatic Cancer." Gastroenterology, vol. 144, no. 6, 2013, pp. 1252-61.
    Yadav D, Lowenfels AB. The epidemiology of pancreatitis and pancreatic cancer. Gastroenterology. 2013;144(6):1252-61.
    Yadav, D., & Lowenfels, A. B. (2013). The epidemiology of pancreatitis and pancreatic cancer. Gastroenterology, 144(6), pp. 1252-61. doi:10.1053/j.gastro.2013.01.068.
    Yadav D, Lowenfels AB. The Epidemiology of Pancreatitis and Pancreatic Cancer. Gastroenterology. 2013;144(6):1252-61. PubMed PMID: 23622135.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The epidemiology of pancreatitis and pancreatic cancer. AU - Yadav,Dhiraj, AU - Lowenfels,Albert B, PY - 2012/10/15/received PY - 2013/01/25/revised PY - 2013/01/30/accepted PY - 2013/4/30/entrez PY - 2013/4/30/pubmed PY - 2013/6/21/medline SP - 1252 EP - 61 JF - Gastroenterology JO - Gastroenterology VL - 144 IS - 6 N2 - Acute pancreatitis is one of the most frequent gastrointestinal causes of hospital admission in the United States. Chronic pancreatitis, although lower in incidence, significantly reduces patients' quality of life. Pancreatic cancer is associated with a high mortality rate and is one of the top 5 causes of death from cancer. The burden of pancreatic disorders is expected to increase over time. The risk and etiology of pancreatitis differ with age and sex, and all pancreatic disorders affect the black population more than any other race. Gallstones are the most common cause of acute pancreatitis, and early cholecystectomy eliminates the risk of future attacks. Alcohol continues to be the single most important risk factor for chronic pancreatitis. Smoking is an independent risk factor for acute and chronic pancreatitis, and its effects could synergize with those of alcohol. Significant risk factors for pancreatic cancer include smoking and non-O blood groups. Alcohol abstinence and smoking cessation can alter the progression of pancreatitis and reduce recurrence; smoking cessation is the most effective strategy to reduce the risk of pancreatic cancer. SN - 1528-0012 UR - https://www.unboundmedicine.com/medline/citation/23622135/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016-5085(13)00168-6 DB - PRIME DP - Unbound Medicine ER -