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Response of bone mineral density, inflammatory cytokines, and biochemical bone markers to a 32-week combined loading exercise programme in older men and women.
Arch Gerontol Geriatr. 2013 Sep-Oct; 57(2):226-33.AG

Abstract

This study examines the effects of 32 weeks of exercise training on balance, lower-extremity muscle strength, bone mineral density (BMD) and serum levels of bone metabolism and inflammatory markers in older adults. Forty-seven healthy older adults (women=24, men=23; mean age 68.2 years) participated in a exercise intervention (60min/session) that included resistance exercise training (2 days/week) at 75-80% of maximum plus a multicomponent weight-bearing impact exercise training (1 day/week). Outcome measures included lumbar spine and proximal femoral BMD, dynamic balance, muscle strength, serum levels of bone metabolism markers [osteocalcin (OC), C-terminal telopeptide of Type I collagen (CTX), osteoprotegerin (OPG) and receptor activator of nuclear factor kappa B ligand (RANKL)] and serum levels of inflammatory markers [high sensitive (hs)-C-reactive protein (CRP), interleukin (IL)-6, tumor necrosis factor (TNF)-α, and interferon (IFN)-γ]. Potential confounding variables included body composition, dietary intake (using 4-day diet records), and accelerometer-based physical activity. After 32 weeks, both men and women increased dynamic balance (6.4%), muscle strength (11.0%) and trochanter (0.7%), intertrochanter (0.7%), total hip (0.6%), and lumbar spine BMD (1.7%), while OC, CTX, OPG and RANKL levels remained unchanged. In addition, hs-CRP and IFN-γ levels were decreased, while TNF-α levels were unchanged, and a decrease in IL-6 levels was only observed in men. These findings suggest that our combined impact protocol reduces inflammation and increases BMD, balance, and lower-extremity muscle strength, despite having little effect on bone metabolism markers. This reinforces the role of exercise to counteract the age-related inflammation, and the muscle strength, balance and BMD reduction.

Authors+Show Affiliations

Research Centre in Physical Activity, Health and Leisure, Faculty of Sport Science, University of Porto, Rua Dr. Plácido Costa 91, 4200-450 Porto, Portugal. emarques@fade.up.ptNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23623588

Citation

Marques, Elisa A., et al. "Response of Bone Mineral Density, Inflammatory Cytokines, and Biochemical Bone Markers to a 32-week Combined Loading Exercise Programme in Older Men and Women." Archives of Gerontology and Geriatrics, vol. 57, no. 2, 2013, pp. 226-33.
Marques EA, Mota J, Viana JL, et al. Response of bone mineral density, inflammatory cytokines, and biochemical bone markers to a 32-week combined loading exercise programme in older men and women. Arch Gerontol Geriatr. 2013;57(2):226-33.
Marques, E. A., Mota, J., Viana, J. L., Tuna, D., Figueiredo, P., Guimarães, J. T., & Carvalho, J. (2013). Response of bone mineral density, inflammatory cytokines, and biochemical bone markers to a 32-week combined loading exercise programme in older men and women. Archives of Gerontology and Geriatrics, 57(2), 226-33. https://doi.org/10.1016/j.archger.2013.03.014
Marques EA, et al. Response of Bone Mineral Density, Inflammatory Cytokines, and Biochemical Bone Markers to a 32-week Combined Loading Exercise Programme in Older Men and Women. Arch Gerontol Geriatr. 2013 Sep-Oct;57(2):226-33. PubMed PMID: 23623588.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Response of bone mineral density, inflammatory cytokines, and biochemical bone markers to a 32-week combined loading exercise programme in older men and women. AU - Marques,Elisa A, AU - Mota,Jorge, AU - Viana,João L, AU - Tuna,Diana, AU - Figueiredo,Pedro, AU - Guimarães,João T, AU - Carvalho,Joana, Y1 - 2013/04/23/ PY - 2013/01/04/received PY - 2013/02/19/revised PY - 2013/03/26/accepted PY - 2013/4/30/entrez PY - 2013/4/30/pubmed PY - 2014/2/11/medline SP - 226 EP - 33 JF - Archives of gerontology and geriatrics JO - Arch Gerontol Geriatr VL - 57 IS - 2 N2 - This study examines the effects of 32 weeks of exercise training on balance, lower-extremity muscle strength, bone mineral density (BMD) and serum levels of bone metabolism and inflammatory markers in older adults. Forty-seven healthy older adults (women=24, men=23; mean age 68.2 years) participated in a exercise intervention (60min/session) that included resistance exercise training (2 days/week) at 75-80% of maximum plus a multicomponent weight-bearing impact exercise training (1 day/week). Outcome measures included lumbar spine and proximal femoral BMD, dynamic balance, muscle strength, serum levels of bone metabolism markers [osteocalcin (OC), C-terminal telopeptide of Type I collagen (CTX), osteoprotegerin (OPG) and receptor activator of nuclear factor kappa B ligand (RANKL)] and serum levels of inflammatory markers [high sensitive (hs)-C-reactive protein (CRP), interleukin (IL)-6, tumor necrosis factor (TNF)-α, and interferon (IFN)-γ]. Potential confounding variables included body composition, dietary intake (using 4-day diet records), and accelerometer-based physical activity. After 32 weeks, both men and women increased dynamic balance (6.4%), muscle strength (11.0%) and trochanter (0.7%), intertrochanter (0.7%), total hip (0.6%), and lumbar spine BMD (1.7%), while OC, CTX, OPG and RANKL levels remained unchanged. In addition, hs-CRP and IFN-γ levels were decreased, while TNF-α levels were unchanged, and a decrease in IL-6 levels was only observed in men. These findings suggest that our combined impact protocol reduces inflammation and increases BMD, balance, and lower-extremity muscle strength, despite having little effect on bone metabolism markers. This reinforces the role of exercise to counteract the age-related inflammation, and the muscle strength, balance and BMD reduction. SN - 1872-6976 UR - https://www.unboundmedicine.com/medline/citation/23623588/Response_of_bone_mineral_density_inflammatory_cytokines_and_biochemical_bone_markers_to_a_32_week_combined_loading_exercise_programme_in_older_men_and_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-4943(13)00047-2 DB - PRIME DP - Unbound Medicine ER -