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Changes in the PCOS phenotype with age.
Steroids 2013; 78(8):761-6S

Abstract

Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder of reproductive-age women. The diagnosis of PCOS is mainly based on the following three components: (1) hyperandrogenism, (2) oligo-amenorrhea, and (3) the observation of polycystic ovaries on a sonogram. The comorbidities may include insulin resistance, type II diabetes mellitus, hypertension and cardiovascular disease. Importantly, the diagnostic criteria and complications related to PCOS are age-dependent. Androgen production in women may decrease because of ovarian aging or decreased production by the adrenal glands over time. The prevalence of hirsutism and acne decreases with age. Ovarian volume and follicle number also decrease with age, with the age-related decrease in follicle number seemingly greater than that of ovarian volume. Aging may also be associated with increased risk of insulin resistance and metabolic disturbances. Therefore, these age-related changes may affect the observed incidence and complications of PCOS. In adolescent patients, the criteria described above pose particular diagnostic problems because the characteristics of normal puberty often overlap with the signs and symptoms of PCOS. Hyperandrogenism and chronic anovulation are the primary disturbances in younger women with PCOS; whereas, obesity, insulin resistance, and metabolic disturbances are predominant in older women with PCOS. The deterioration of insulin resistance during the reproductive life of women with PCOS appears to be mainly attributable to the increase in obesity. Therefore, if body weight could be controlled properly, younger hyperandrogenic PCOS women might reduce their risk of insulin resistance and metabolic disturbances later in life.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Wan Fang Hospital, Taipei Medical University, No.111, Sec. 3, Xinglong Road, Taipei 11696, Taiwan. hsumingi@yahoo.com.tw

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23624031

Citation

Hsu, Ming-I. "Changes in the PCOS Phenotype With Age." Steroids, vol. 78, no. 8, 2013, pp. 761-6.
Hsu MI. Changes in the PCOS phenotype with age. Steroids. 2013;78(8):761-6.
Hsu, M. I. (2013). Changes in the PCOS phenotype with age. Steroids, 78(8), pp. 761-6. doi:10.1016/j.steroids.2013.04.005.
Hsu MI. Changes in the PCOS Phenotype With Age. Steroids. 2013;78(8):761-6. PubMed PMID: 23624031.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in the PCOS phenotype with age. A1 - Hsu,Ming-I, Y1 - 2013/04/25/ PY - 2013/03/21/received PY - 2013/03/23/revised PY - 2013/03/23/accepted PY - 2013/4/30/entrez PY - 2013/4/30/pubmed PY - 2014/1/25/medline SP - 761 EP - 6 JF - Steroids JO - Steroids VL - 78 IS - 8 N2 - Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder of reproductive-age women. The diagnosis of PCOS is mainly based on the following three components: (1) hyperandrogenism, (2) oligo-amenorrhea, and (3) the observation of polycystic ovaries on a sonogram. The comorbidities may include insulin resistance, type II diabetes mellitus, hypertension and cardiovascular disease. Importantly, the diagnostic criteria and complications related to PCOS are age-dependent. Androgen production in women may decrease because of ovarian aging or decreased production by the adrenal glands over time. The prevalence of hirsutism and acne decreases with age. Ovarian volume and follicle number also decrease with age, with the age-related decrease in follicle number seemingly greater than that of ovarian volume. Aging may also be associated with increased risk of insulin resistance and metabolic disturbances. Therefore, these age-related changes may affect the observed incidence and complications of PCOS. In adolescent patients, the criteria described above pose particular diagnostic problems because the characteristics of normal puberty often overlap with the signs and symptoms of PCOS. Hyperandrogenism and chronic anovulation are the primary disturbances in younger women with PCOS; whereas, obesity, insulin resistance, and metabolic disturbances are predominant in older women with PCOS. The deterioration of insulin resistance during the reproductive life of women with PCOS appears to be mainly attributable to the increase in obesity. Therefore, if body weight could be controlled properly, younger hyperandrogenic PCOS women might reduce their risk of insulin resistance and metabolic disturbances later in life. SN - 1878-5867 UR - https://www.unboundmedicine.com/medline/citation/23624031/Changes_in_the_PCOS_phenotype_with_age_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0039-128X(13)00087-1 DB - PRIME DP - Unbound Medicine ER -