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Intake of whole grains from different cereal and food sources and incidence of colorectal cancer in the Scandinavian HELGA cohort.
Cancer Causes Control 2013; 24(7):1363-74CC

Abstract

PURPOSE

A high intake of whole grains has been associated with a lower incidence of colorectal cancer, but few studies are available on the association with whole grains from different cereals, for example, wheat, rye and oats, and none has addressed these separately. The objective of this study was to investigate the association between whole-grain intake and colorectal cancer.

METHOD

We used data from the large population-based Scandinavian cohort HELGA consisting of 108,000 Danish, Swedish, and Norwegian persons, of whom 1,123 developed colorectal cancer during a median of 11 years of follow-up. Detailed information on daily intake of whole-grain products, including whole-grain bread, crispbread, and breakfast cereals, was available, and intakes of total whole grains and specific whole-grain species (wheat, rye, and oats) were estimated. Associations between these whole-grain variables and the incidence of colorectal cancer were investigated using Cox proportional hazards models. Intake of whole-grain products was associated with a lower incidence of colorectal cancer per 50-g increment (incidence rate ratio [IRR], 0.94; 95% confidence interval [CI], 0.89, 0.99), and the same tendency was found for total whole-grain intake (IRR pr. 25-g increment, 0.94; 95% CI, 0.88, 1.01). Intake of whole-grain wheat was associated with a lower incidence of colorectal cancer (IRR for highest versus lowest quartile of intake, 0.66; 95% CI, 0.51, 0.85), but no statistical significant linear trend was observed (p for trend: 0.18). No significant association was found for whole-grain rye or oats.

CONCLUSION

Whole-grain intake was associated with a lower incidence of colorectal cancer.

Authors+Show Affiliations

Danish Cancer Society Research Center, Copenhagen Ø, Denmark. ceciliek@cancer.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23624874

Citation

Kyrø, Cecilie, et al. "Intake of Whole Grains From Different Cereal and Food Sources and Incidence of Colorectal Cancer in the Scandinavian HELGA Cohort." Cancer Causes & Control : CCC, vol. 24, no. 7, 2013, pp. 1363-74.
Kyrø C, Skeie G, Loft S, et al. Intake of whole grains from different cereal and food sources and incidence of colorectal cancer in the Scandinavian HELGA cohort. Cancer Causes Control. 2013;24(7):1363-74.
Kyrø, C., Skeie, G., Loft, S., Landberg, R., Christensen, J., Lund, E., ... Olsen, A. (2013). Intake of whole grains from different cereal and food sources and incidence of colorectal cancer in the Scandinavian HELGA cohort. Cancer Causes & Control : CCC, 24(7), pp. 1363-74. doi:10.1007/s10552-013-0215-z.
Kyrø C, et al. Intake of Whole Grains From Different Cereal and Food Sources and Incidence of Colorectal Cancer in the Scandinavian HELGA Cohort. Cancer Causes Control. 2013;24(7):1363-74. PubMed PMID: 23624874.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intake of whole grains from different cereal and food sources and incidence of colorectal cancer in the Scandinavian HELGA cohort. AU - Kyrø,Cecilie, AU - Skeie,Guri, AU - Loft,Steffen, AU - Landberg,Rikard, AU - Christensen,Jane, AU - Lund,Eiliv, AU - Nilsson,Lena M, AU - Palmqvist,Richard, AU - Tjønneland,Anne, AU - Olsen,Anja, Y1 - 2013/04/30/ PY - 2013/02/01/received PY - 2013/04/16/accepted PY - 2013/4/30/entrez PY - 2013/4/30/pubmed PY - 2014/1/10/medline SP - 1363 EP - 74 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 24 IS - 7 N2 - PURPOSE: A high intake of whole grains has been associated with a lower incidence of colorectal cancer, but few studies are available on the association with whole grains from different cereals, for example, wheat, rye and oats, and none has addressed these separately. The objective of this study was to investigate the association between whole-grain intake and colorectal cancer. METHOD: We used data from the large population-based Scandinavian cohort HELGA consisting of 108,000 Danish, Swedish, and Norwegian persons, of whom 1,123 developed colorectal cancer during a median of 11 years of follow-up. Detailed information on daily intake of whole-grain products, including whole-grain bread, crispbread, and breakfast cereals, was available, and intakes of total whole grains and specific whole-grain species (wheat, rye, and oats) were estimated. Associations between these whole-grain variables and the incidence of colorectal cancer were investigated using Cox proportional hazards models. Intake of whole-grain products was associated with a lower incidence of colorectal cancer per 50-g increment (incidence rate ratio [IRR], 0.94; 95% confidence interval [CI], 0.89, 0.99), and the same tendency was found for total whole-grain intake (IRR pr. 25-g increment, 0.94; 95% CI, 0.88, 1.01). Intake of whole-grain wheat was associated with a lower incidence of colorectal cancer (IRR for highest versus lowest quartile of intake, 0.66; 95% CI, 0.51, 0.85), but no statistical significant linear trend was observed (p for trend: 0.18). No significant association was found for whole-grain rye or oats. CONCLUSION: Whole-grain intake was associated with a lower incidence of colorectal cancer. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/23624874/Intake_of_whole_grains_from_different_cereal_and_food_sources_and_incidence_of_colorectal_cancer_in_the_Scandinavian_HELGA_cohort_ L2 - https://doi.org/10.1007/s10552-013-0215-z DB - PRIME DP - Unbound Medicine ER -