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Catechins in dietary supplements and hepatotoxicity.

Abstract

BACKGROUND

Many herbal dietary supplements (HDS) contain green tea extract (GTE) and its component catechins, although their presence may not always be indicated on the product label.

PURPOSE

Because GTE and catechins have been implicated in human hepatotoxicity in several case reports, our objective was to determine whether catechins were present in HDS that were implicated in hepatotoxicity, even if not identified among the labeled ingredients, and whether these compounds could be associated with liver injury.

METHODS

We assayed 97 HDS implicated in human hepatotoxicity for catechins.

RESULTS

We found that 29 of 73 HDS (39.7%) that did not identify GTE or any of its component catechins on their label contained catechins. Among patients with confirmed hepatotoxicity, there was no statistically significant association between the presence of catechin or the dose consumed and liver injury causality score, severity, or pattern of liver injury. Catechin levels tended to be highest in products used for weight loss, although catechin concentrations were low in most products.

CONCLUSIONS

Many HDS commonly contain catechins that are implicated in hepatotoxicity, although their presence may not be indicated on the product label. Although our results did not establish an association between GTE or catechins with hepatotoxicity, they highlight some of the many complexities and uncertainties that surround the attribution of drug-induced liver injury (DILI) to HDS.

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  • Authors+Show Affiliations

    ,

    Division of Hepatology, Einstein Medical Center, 5401 Old York Road, Suite 505, Philadelphia, PA 19141, USA. NavarroV@einstein.edu

    , , , ,

    Source

    Digestive diseases and sciences 58:9 2013 Sep pg 2682-90

    MeSH

    Adult
    Catechin
    Chemical and Drug Induced Liver Injury
    Dietary Supplements
    Female
    Humans
    Male
    Middle Aged
    Plant Preparations
    Young Adult

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    23625293

    Citation

    Navarro, Victor J., et al. "Catechins in Dietary Supplements and Hepatotoxicity." Digestive Diseases and Sciences, vol. 58, no. 9, 2013, pp. 2682-90.
    Navarro VJ, Bonkovsky HL, Hwang SI, et al. Catechins in dietary supplements and hepatotoxicity. Dig Dis Sci. 2013;58(9):2682-90.
    Navarro, V. J., Bonkovsky, H. L., Hwang, S. I., Vega, M., Barnhart, H., & Serrano, J. (2013). Catechins in dietary supplements and hepatotoxicity. Digestive Diseases and Sciences, 58(9), pp. 2682-90. doi:10.1007/s10620-013-2687-9.
    Navarro VJ, et al. Catechins in Dietary Supplements and Hepatotoxicity. Dig Dis Sci. 2013;58(9):2682-90. PubMed PMID: 23625293.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Catechins in dietary supplements and hepatotoxicity. AU - Navarro,Victor J, AU - Bonkovsky,Herbert L, AU - Hwang,Sun-Il, AU - Vega,Maricruz, AU - Barnhart,Huiman, AU - Serrano,Jose, Y1 - 2013/04/27/ PY - 2013/01/24/received PY - 2013/04/09/accepted PY - 2013/4/30/entrez PY - 2013/4/30/pubmed PY - 2013/12/16/medline SP - 2682 EP - 90 JF - Digestive diseases and sciences JO - Dig. Dis. Sci. VL - 58 IS - 9 N2 - BACKGROUND: Many herbal dietary supplements (HDS) contain green tea extract (GTE) and its component catechins, although their presence may not always be indicated on the product label. PURPOSE: Because GTE and catechins have been implicated in human hepatotoxicity in several case reports, our objective was to determine whether catechins were present in HDS that were implicated in hepatotoxicity, even if not identified among the labeled ingredients, and whether these compounds could be associated with liver injury. METHODS: We assayed 97 HDS implicated in human hepatotoxicity for catechins. RESULTS: We found that 29 of 73 HDS (39.7%) that did not identify GTE or any of its component catechins on their label contained catechins. Among patients with confirmed hepatotoxicity, there was no statistically significant association between the presence of catechin or the dose consumed and liver injury causality score, severity, or pattern of liver injury. Catechin levels tended to be highest in products used for weight loss, although catechin concentrations were low in most products. CONCLUSIONS: Many HDS commonly contain catechins that are implicated in hepatotoxicity, although their presence may not be indicated on the product label. Although our results did not establish an association between GTE or catechins with hepatotoxicity, they highlight some of the many complexities and uncertainties that surround the attribution of drug-induced liver injury (DILI) to HDS. SN - 1573-2568 UR - https://www.unboundmedicine.com/medline/citation/23625293/Catechins_in_dietary_supplements_and_hepatotoxicity_ L2 - https://doi.org/10.1007/s10620-013-2687-9 DB - PRIME DP - Unbound Medicine ER -