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The effect of oral evening primrose oil on menopausal hot flashes: a randomized clinical trial.
Arch Gynecol Obstet. 2013 Nov; 288(5):1075-9.AG

Abstract

PURPOSE

Hot flashes are common experience for menopausal women, and for many, are severe enough to significantly compromise their overall sense of well being and quality of life. The aim of this study was to compare the efficacy of evening primrose with placebo in improvement of menopausal hot flashes.

METHODS

In a 6-week randomized clinical trial, a total of 56 menopausal women aged 45-59 years were participated in this study. The patients were asked for their hot flashes characteristics and responded to HFRDIS (hot flash related daily interference scale) questionnaire before and after the intervention. The participants were randomly assigned to take two capsules per day (totally 90 capsules for 6 weeks) of placebo or evening primrose (500 mg) for continuous 6 weeks. Then, the improvement in hot flashes was compared between two groups.

RESULTS

The percent of improvement in hot flash frequency, severity and duration were 39, 42 and 19 %, in evening primrose group compared with 32, 32 and 18 % in placebo group, respectively. Although all three characters of hot flash was ameliorated in evening primrose arm, only its severity was significantly better in this arm compared with placebo group (P < 0.05). All HFRDIS score were significantly improved in two groups, but the percentage of improvement in social activities, relations with others, and sexuality was significantly superior to placebo group (P < 0.05).

CONCLUSIONS

The application of oral evening primrose oil compared with placebo for controlling hot flashes may decrease more the intensity of attacks as well as ameliorating the HFRDIS score.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Farzaneh F
Gynecology Translational Research Center (GTRC), Imam Hossein Hospital, Shaheed Beheshti University of Medical Sciences, 16177-63141, Tehran, Iran, farahzaneh@yahoo.com.
Fatehi S
No affiliation info available
Sohrabi MR
No affiliation info available
Alizadeh K
No affiliation info available

MeSH

FemaleHot FlashesHumansInterpersonal RelationsMenopauseMiddle AgedOenothera biennisPhytotherapyPlant ExtractsQuality of LifeSeedsSeverity of Illness IndexSexualitySocial Participation

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

23625331

Citation

Farzaneh, Farah, et al. "The Effect of Oral Evening Primrose Oil On Menopausal Hot Flashes: a Randomized Clinical Trial." Archives of Gynecology and Obstetrics, vol. 288, no. 5, 2013, pp. 1075-9.
Farzaneh F, Fatehi S, Sohrabi MR, et al. The effect of oral evening primrose oil on menopausal hot flashes: a randomized clinical trial. Arch Gynecol Obstet. 2013;288(5):1075-9.
Farzaneh, F., Fatehi, S., Sohrabi, M. R., & Alizadeh, K. (2013). The effect of oral evening primrose oil on menopausal hot flashes: a randomized clinical trial. Archives of Gynecology and Obstetrics, 288(5), 1075-9. https://doi.org/10.1007/s00404-013-2852-6
Farzaneh F, et al. The Effect of Oral Evening Primrose Oil On Menopausal Hot Flashes: a Randomized Clinical Trial. Arch Gynecol Obstet. 2013;288(5):1075-9. PubMed PMID: 23625331.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of oral evening primrose oil on menopausal hot flashes: a randomized clinical trial. AU - Farzaneh,Farah, AU - Fatehi,Setareh, AU - Sohrabi,Mohammad-Reza, AU - Alizadeh,Kamyab, Y1 - 2013/04/27/ PY - 2012/06/19/received PY - 2013/04/13/accepted PY - 2013/4/30/entrez PY - 2013/4/30/pubmed PY - 2014/6/26/medline SP - 1075 EP - 9 JF - Archives of gynecology and obstetrics JO - Arch Gynecol Obstet VL - 288 IS - 5 N2 - PURPOSE: Hot flashes are common experience for menopausal women, and for many, are severe enough to significantly compromise their overall sense of well being and quality of life. The aim of this study was to compare the efficacy of evening primrose with placebo in improvement of menopausal hot flashes. METHODS: In a 6-week randomized clinical trial, a total of 56 menopausal women aged 45-59 years were participated in this study. The patients were asked for their hot flashes characteristics and responded to HFRDIS (hot flash related daily interference scale) questionnaire before and after the intervention. The participants were randomly assigned to take two capsules per day (totally 90 capsules for 6 weeks) of placebo or evening primrose (500 mg) for continuous 6 weeks. Then, the improvement in hot flashes was compared between two groups. RESULTS: The percent of improvement in hot flash frequency, severity and duration were 39, 42 and 19 %, in evening primrose group compared with 32, 32 and 18 % in placebo group, respectively. Although all three characters of hot flash was ameliorated in evening primrose arm, only its severity was significantly better in this arm compared with placebo group (P < 0.05). All HFRDIS score were significantly improved in two groups, but the percentage of improvement in social activities, relations with others, and sexuality was significantly superior to placebo group (P < 0.05). CONCLUSIONS: The application of oral evening primrose oil compared with placebo for controlling hot flashes may decrease more the intensity of attacks as well as ameliorating the HFRDIS score. SN - 1432-0711 UR - https://www.unboundmedicine.com/medline/citation/23625331/The_effect_of_oral_evening_primrose_oil_on_menopausal_hot_flashes:_a_randomized_clinical_trial_ DB - PRIME DP - Unbound Medicine ER -