Tags

Type your tag names separated by a space and hit enter

Preparation, characterization and tableting of cilnidipine solid dispersions.
Pak J Pharm Sci. 2013 May; 26(3):629-36.PJ

Abstract

Solid dispersion technique has been developed many years for improving solubility of water-insoluble drugs, aiming to achieve a better oral bioavailability. However, this technique exhibits many inconveniences when used for large-scale tableting procedures. The objective of current research work was to develop cilnidipine solid dispersions (SDs) to improve the dissolution behaviors of this water-insoluble drug. Moreover, an innovative granulation method was designed to simplify the traditional tableting technology used in solid dispersion technique. Three different kinds of polymers, polyethylene glycol (PEG), polyvinylpyrrolidone (PVP) and poloxamer, were used as carriers to prepare solid dispersions. The interactions in the solid state were characterized by differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD) and FT-IR spectroscopy. The designed granulation method was employed to prepare solid dispersion tablets and the formulation was optimized through investigating the dissolution behaviors. The results indicated PEG solid dispersion showed the best effect both on physical characterizations and dissolution studies. Furthermore, all type of solid dispersions significantly improved the dissolution rates when compared to pure drug and its corresponding physical mixture (PM). The solid dispersion tablets prepared in simplified tableting method exhibited better operability, stability and dissolution behavior than the tablets prepared in traditional ways, which brought more opportunities to solid dispersion technique for industrial production.

Authors+Show Affiliations

College of Pharmaceutical Sciences, Hebei University, Baoding, China. hbupharm@126.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23625441

Citation

Hu, Liandong, et al. "Preparation, Characterization and Tableting of Cilnidipine Solid Dispersions." Pakistan Journal of Pharmaceutical Sciences, vol. 26, no. 3, 2013, pp. 629-36.
Hu L, Song W, Niu F, et al. Preparation, characterization and tableting of cilnidipine solid dispersions. Pak J Pharm Sci. 2013;26(3):629-36.
Hu, L., Song, W., Niu, F., Jiao, K., & Jia, Z. (2013). Preparation, characterization and tableting of cilnidipine solid dispersions. Pakistan Journal of Pharmaceutical Sciences, 26(3), 629-36.
Hu L, et al. Preparation, Characterization and Tableting of Cilnidipine Solid Dispersions. Pak J Pharm Sci. 2013;26(3):629-36. PubMed PMID: 23625441.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation, characterization and tableting of cilnidipine solid dispersions. AU - Hu,Liandong, AU - Song,Weihua, AU - Niu,Feng, AU - Jiao,Kuiliang, AU - Jia,Zheng, PY - 2013/4/30/entrez PY - 2013/4/30/pubmed PY - 2013/8/2/medline SP - 629 EP - 36 JF - Pakistan journal of pharmaceutical sciences JO - Pak J Pharm Sci VL - 26 IS - 3 N2 - Solid dispersion technique has been developed many years for improving solubility of water-insoluble drugs, aiming to achieve a better oral bioavailability. However, this technique exhibits many inconveniences when used for large-scale tableting procedures. The objective of current research work was to develop cilnidipine solid dispersions (SDs) to improve the dissolution behaviors of this water-insoluble drug. Moreover, an innovative granulation method was designed to simplify the traditional tableting technology used in solid dispersion technique. Three different kinds of polymers, polyethylene glycol (PEG), polyvinylpyrrolidone (PVP) and poloxamer, were used as carriers to prepare solid dispersions. The interactions in the solid state were characterized by differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD) and FT-IR spectroscopy. The designed granulation method was employed to prepare solid dispersion tablets and the formulation was optimized through investigating the dissolution behaviors. The results indicated PEG solid dispersion showed the best effect both on physical characterizations and dissolution studies. Furthermore, all type of solid dispersions significantly improved the dissolution rates when compared to pure drug and its corresponding physical mixture (PM). The solid dispersion tablets prepared in simplified tableting method exhibited better operability, stability and dissolution behavior than the tablets prepared in traditional ways, which brought more opportunities to solid dispersion technique for industrial production. SN - 1011-601X UR - https://www.unboundmedicine.com/medline/citation/23625441/Preparation_characterization_and_tableting_of_cilnidipine_solid_dispersions_ DB - PRIME DP - Unbound Medicine ER -