TY - JOUR T1 - Report: Simultaneous determination of naphazoline hydrochloride, chlorpheniramine maleate and methylene blue in their ternary mixture. AU - Ali,Nouruddin Wageih, AU - Hegazy,Maha Ahmad, AU - Abdelkawy,Mohamad, AU - Abdelfatah,Rehab Magdy, PY - 2013/4/30/entrez PY - 2013/4/30/pubmed PY - 2013/8/2/medline SP - 641 EP - 8 JF - Pakistan journal of pharmaceutical sciences JO - Pak J Pharm Sci VL - 26 IS - 3 N2 - Validated spectrophotometric and chemometric methods were developed for determination of Naphazoline Hydrochloride (NAP), Chlorpheniramine maleate (CLO) and Methylene blue (MB) in their ternary mixture. Method A was a spectrophotometric method, where NAP and MB were determined using second derivative (D²) spectrophoto metric method using the peak amplitudes at 299 nm and 337 nm for NAP and MB respectively , while CLO was determined using second derivative ratio (DD²) spectrophotometric method using the peak amplitude at 276.6 nm. Method B used the chemometric techniques; principal component regression (PCR) and partial least squares (PLS) for determination of NAP, CLO and MB using the information contained in the absorption spectra of their ternary mixture solutions. The proposed methods have been successfully applied for the analysis of NAP, CLO and MB in their pharmaceutical formulation and the obtained results were statistically compared with the reported methods. SN - 1011-601X UR - https://www.unboundmedicine.com/medline/citation/23625443/Report:_Simultaneous_determination_of_naphazoline_hydrochloride_chlorpheniramine_maleate_and_methylene_blue_in_their_ternary_mixture_ L2 - https://antibodies.cancer.gov/detail/CPTC-AKR1C2-1 DB - PRIME DP - Unbound Medicine ER -