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Lifestyle and dietary factors in relation to risk of chronic myeloid leukemia in the NIH-AARP Diet and Health Study.

Abstract

BACKGROUND

Aside from exposure to ionizing radiation and benzene, little is known about lifestyle risk factors for chronic myeloid leukemia (CML) in the general population.

METHODS

We examined the relation between lifestyle and dietary risk factors for CML in 493,188 participants (294,271 males and 198,917 females) aged 50 to 71 years who completed a baseline questionnaire in the National Institutes of Health-AARP Diet and Health Study in 1995 to 1996. Over a median of 10.5 years of follow-up, 178 incident cases of CML (139 males and 39 females) were ascertained from state registries. We used Cox proportional hazards models to estimate hazard ratios and 95% confidence intervals for exposures of interest, adjusting for potential confounding variables.

RESULTS

In multivariable analysis of all participants combined, female sex, years of education, and vigorous physical activity (HR for ≥3 times/week vs. <1 time/week 0.70; 95% CI, 0.49-0.99) were inversely associated with risk of CML, whereas smoking intensity (HR for smokers of ≥20 cigarettes per day vs. never smokers: 1.53; 95% CI, 1.03-2.27) and body mass (HR for BMI ≥ 30 vs. <25 kg/m(2) 1.46; 95% CI, 0.95-2.23) were associated with increased risk. A range of dietary factors was not associated with disease.

CONCLUSIONS

This study adds to the sparse information about lifestyle factors, which affect the risk of CML in the general population.

IMPACT

If these findings are confirmed, it would suggest that CML may be amenable to preventive strategies.

Authors+Show Affiliations

Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Geoffrey.kabat@einstein.yu.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23625904

Citation

Kabat, Geoffrey C., et al. "Lifestyle and Dietary Factors in Relation to Risk of Chronic Myeloid Leukemia in the NIH-AARP Diet and Health Study." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 22, no. 5, 2013, pp. 848-54.
Kabat GC, Wu JW, Moore SC, et al. Lifestyle and dietary factors in relation to risk of chronic myeloid leukemia in the NIH-AARP Diet and Health Study. Cancer Epidemiol Biomarkers Prev. 2013;22(5):848-54.
Kabat, G. C., Wu, J. W., Moore, S. C., Morton, L. M., Park, Y., Hollenbeck, A. R., & Rohan, T. E. (2013). Lifestyle and dietary factors in relation to risk of chronic myeloid leukemia in the NIH-AARP Diet and Health Study. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 22(5), pp. 848-54. doi:10.1158/1055-9965.EPI-13-0093.
Kabat GC, et al. Lifestyle and Dietary Factors in Relation to Risk of Chronic Myeloid Leukemia in the NIH-AARP Diet and Health Study. Cancer Epidemiol Biomarkers Prev. 2013;22(5):848-54. PubMed PMID: 23625904.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lifestyle and dietary factors in relation to risk of chronic myeloid leukemia in the NIH-AARP Diet and Health Study. AU - Kabat,Geoffrey C, AU - Wu,Jennifer W, AU - Moore,Steven C, AU - Morton,Lindsay M, AU - Park,Yikyung, AU - Hollenbeck,Albert R, AU - Rohan,Thomas E, Y1 - 2013/04/26/ PY - 2013/4/30/entrez PY - 2013/4/30/pubmed PY - 2013/11/8/medline SP - 848 EP - 54 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 22 IS - 5 N2 - BACKGROUND: Aside from exposure to ionizing radiation and benzene, little is known about lifestyle risk factors for chronic myeloid leukemia (CML) in the general population. METHODS: We examined the relation between lifestyle and dietary risk factors for CML in 493,188 participants (294,271 males and 198,917 females) aged 50 to 71 years who completed a baseline questionnaire in the National Institutes of Health-AARP Diet and Health Study in 1995 to 1996. Over a median of 10.5 years of follow-up, 178 incident cases of CML (139 males and 39 females) were ascertained from state registries. We used Cox proportional hazards models to estimate hazard ratios and 95% confidence intervals for exposures of interest, adjusting for potential confounding variables. RESULTS: In multivariable analysis of all participants combined, female sex, years of education, and vigorous physical activity (HR for ≥3 times/week vs. <1 time/week 0.70; 95% CI, 0.49-0.99) were inversely associated with risk of CML, whereas smoking intensity (HR for smokers of ≥20 cigarettes per day vs. never smokers: 1.53; 95% CI, 1.03-2.27) and body mass (HR for BMI ≥ 30 vs. <25 kg/m(2) 1.46; 95% CI, 0.95-2.23) were associated with increased risk. A range of dietary factors was not associated with disease. CONCLUSIONS: This study adds to the sparse information about lifestyle factors, which affect the risk of CML in the general population. IMPACT: If these findings are confirmed, it would suggest that CML may be amenable to preventive strategies. SN - 1538-7755 UR - https://www.unboundmedicine.com/medline/citation/23625904/Lifestyle_and_dietary_factors_in_relation_to_risk_of_chronic_myeloid_leukemia_in_the_NIH_AARP_Diet_and_Health_Study_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&amp;pmid=23625904 DB - PRIME DP - Unbound Medicine ER -