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Pirimicarb-based formulation-induced genotoxicity and cytotoxicity in the freshwater fish Cnesterodon decemmaculatus (Jenyns, 1842) (Pisces, Poeciliidae).
Toxicol Ind Health. 2015 Nov; 31(11):1051-60.TI

Abstract

We analyzed the aspects of lethality, genotoxicity, and cytotoxicity in the ten spotted live-bearer exposed under laboratory conditions to the pirimicarb-based formulation Patton Flow® (50% active ingredient (a.i.)). Acute effects were evaluated using different end points for lethality, genotoxicity, and cytotoxicity. Median lethal concentration (LC50) estimation was employed as a bioassay for lethality, whereas micronucleus (MN) induction and alterations in erythrocyte/erythroblast frequency were used as end points for genotoxicity and cytotoxicity, respectively. Results demonstrated an LC5096h value of 88 mg/L. Patton Flow® increased the MN frequency in fish erythrocytes after 48 h of exposure at a concentration of 66 mg/L, whereas a concentration range of 22-66 mg/L was able to exert the same genotoxic effect at 96 h of treatment. Furthermore, cytotoxicity was also observed by alterations in erythrocyte/erythroblast frequencies within the concentration range of 22-66 mg/L, regardless of the exposure time. Our current observations provide evidence that Patton Flow® (50% a.i.) should be considered a clear lethal, cytotoxic, and genotoxic agent on Cnesterodon decemmaculatus. Thus, repeated applications of this carbamic insecticide can enter the aquatic environment and exert deleterious effects on aquatic organisms other than the evaluated species C. decemmaculatus.

Authors+Show Affiliations

Cátedra de Citología, Facultad de Ciencias Naturales y Museo, Universidad Nacional de La Plata Calle 64 No. 3, La Plata, Argentina Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina.Cátedra de Citología, Facultad de Ciencias Naturales y Museo, Universidad Nacional de La Plata Calle 64 No. 3, La Plata, Argentina Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina.Cátedra de Citología, Facultad de Ciencias Naturales y Museo, Universidad Nacional de La Plata Calle 64 No. 3, La Plata, Argentina Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina marcelo.larramendy@gmail.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23625907

Citation

Vera-Candioti, Josefina, et al. "Pirimicarb-based Formulation-induced Genotoxicity and Cytotoxicity in the Freshwater Fish Cnesterodon Decemmaculatus (Jenyns, 1842) (Pisces, Poeciliidae)." Toxicology and Industrial Health, vol. 31, no. 11, 2015, pp. 1051-60.
Vera-Candioti J, Soloneski S, Larramendy ML. Pirimicarb-based formulation-induced genotoxicity and cytotoxicity in the freshwater fish Cnesterodon decemmaculatus (Jenyns, 1842) (Pisces, Poeciliidae). Toxicol Ind Health. 2015;31(11):1051-60.
Vera-Candioti, J., Soloneski, S., & Larramendy, M. L. (2015). Pirimicarb-based formulation-induced genotoxicity and cytotoxicity in the freshwater fish Cnesterodon decemmaculatus (Jenyns, 1842) (Pisces, Poeciliidae). Toxicology and Industrial Health, 31(11), 1051-60. https://doi.org/10.1177/0748233713486958
Vera-Candioti J, Soloneski S, Larramendy ML. Pirimicarb-based Formulation-induced Genotoxicity and Cytotoxicity in the Freshwater Fish Cnesterodon Decemmaculatus (Jenyns, 1842) (Pisces, Poeciliidae). Toxicol Ind Health. 2015;31(11):1051-60. PubMed PMID: 23625907.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pirimicarb-based formulation-induced genotoxicity and cytotoxicity in the freshwater fish Cnesterodon decemmaculatus (Jenyns, 1842) (Pisces, Poeciliidae). AU - Vera-Candioti,Josefina, AU - Soloneski,Sonia, AU - Larramendy,Marcelo L, Y1 - 2013/04/26/ PY - 2013/4/30/entrez PY - 2013/4/30/pubmed PY - 2016/8/20/medline KW - Patton Flow® KW - erythrocyte:erythroblast ratio KW - micronucleus KW - mortality KW - poeciliidae SP - 1051 EP - 60 JF - Toxicology and industrial health JO - Toxicol Ind Health VL - 31 IS - 11 N2 - We analyzed the aspects of lethality, genotoxicity, and cytotoxicity in the ten spotted live-bearer exposed under laboratory conditions to the pirimicarb-based formulation Patton Flow® (50% active ingredient (a.i.)). Acute effects were evaluated using different end points for lethality, genotoxicity, and cytotoxicity. Median lethal concentration (LC50) estimation was employed as a bioassay for lethality, whereas micronucleus (MN) induction and alterations in erythrocyte/erythroblast frequency were used as end points for genotoxicity and cytotoxicity, respectively. Results demonstrated an LC5096h value of 88 mg/L. Patton Flow® increased the MN frequency in fish erythrocytes after 48 h of exposure at a concentration of 66 mg/L, whereas a concentration range of 22-66 mg/L was able to exert the same genotoxic effect at 96 h of treatment. Furthermore, cytotoxicity was also observed by alterations in erythrocyte/erythroblast frequencies within the concentration range of 22-66 mg/L, regardless of the exposure time. Our current observations provide evidence that Patton Flow® (50% a.i.) should be considered a clear lethal, cytotoxic, and genotoxic agent on Cnesterodon decemmaculatus. Thus, repeated applications of this carbamic insecticide can enter the aquatic environment and exert deleterious effects on aquatic organisms other than the evaluated species C. decemmaculatus. SN - 1477-0393 UR - https://www.unboundmedicine.com/medline/citation/23625907/Pirimicarb_based_formulation_induced_genotoxicity_and_cytotoxicity_in_the_freshwater_fish_Cnesterodon_decemmaculatus__Jenyns_1842___Pisces_Poeciliidae__ L2 - https://journals.sagepub.com/doi/10.1177/0748233713486958?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -