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Positive association between plasma levels of oxidized low-density lipoprotein and myeloperoxidase after hemodialysis in patients with diabetic end-stage renal disease.
Hemodial Int 2013; 17(4):557-67HI

Abstract

End-stage renal disease (ESRD) patients undergoing hemodialysis (HD) have a high prevalence of cardiovascular events. Low-density lipoprotein (LDL) in dialysis patients has been shown to be susceptible to in vitro peroxidation; therefore, oxidized-LDL (ox-LDL) could be generated in these patients. Moreover, myeloperoxidase (MPO) released from activated neutrophils may play a role in the induction of LDL oxidation. The purpose of this study was to investigate the relationship between plasma ox-LDL levels, plasma MPO levels, and serum high-sensitivity C-reactive protein (hs-CRP) levels during initial HD in patients with diabetic ESRD. Patients (n=28) had serial venous blood samples drawn before and after HD at the initial, second, and third sessions. Plasma ox-LDL levels were measured using a specific monoclonal antibody (DLH3), and plasma MPO levels were measured using an enzyme-linked immunosorbent assay kit. Plasma ox-LDL levels and MPO levels after a single HD session increased significantly (ox-LDL, P<0.005; MPO, P<0.0001) compared with levels before that HD session. However, the increase was transient since the levels returned to pre-HD session levels. Additionally, plasma MPO levels showed a positive correlation with plasma ox-LDL levels during HD (R=0.62, P=0.0029). No significant change was observed in serum hs-CRP levels before and after each HD session. This study demonstrates that plasma MPO levels are directly associated with plasma ox-LDL levels in diabetic ESRD patients during initial HD. These findings suggest a pivotal role for MPO and ox-LDL in the progression and acceleration of atherosclerosis in patients undergoing HD.

Authors+Show Affiliations

Department of Pathology, Osaka City University Graduate School of Medicine, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23627905

Citation

Kitabayashi, Chizuko, et al. "Positive Association Between Plasma Levels of Oxidized Low-density Lipoprotein and Myeloperoxidase After Hemodialysis in Patients With Diabetic End-stage Renal Disease." Hemodialysis International. International Symposium On Home Hemodialysis, vol. 17, no. 4, 2013, pp. 557-67.
Kitabayashi C, Naruko T, Sugioka K, et al. Positive association between plasma levels of oxidized low-density lipoprotein and myeloperoxidase after hemodialysis in patients with diabetic end-stage renal disease. Hemodial Int. 2013;17(4):557-67.
Kitabayashi, C., Naruko, T., Sugioka, K., Yunoki, K., Nakagawa, M., Inaba, M., ... Ueda, M. (2013). Positive association between plasma levels of oxidized low-density lipoprotein and myeloperoxidase after hemodialysis in patients with diabetic end-stage renal disease. Hemodialysis International. International Symposium On Home Hemodialysis, 17(4), pp. 557-67. doi:10.1111/hdi.12049.
Kitabayashi C, et al. Positive Association Between Plasma Levels of Oxidized Low-density Lipoprotein and Myeloperoxidase After Hemodialysis in Patients With Diabetic End-stage Renal Disease. Hemodial Int. 2013;17(4):557-67. PubMed PMID: 23627905.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Positive association between plasma levels of oxidized low-density lipoprotein and myeloperoxidase after hemodialysis in patients with diabetic end-stage renal disease. AU - Kitabayashi,Chizuko, AU - Naruko,Takahiko, AU - Sugioka,Kenichi, AU - Yunoki,Kei, AU - Nakagawa,Masashi, AU - Inaba,Mayumi, AU - Ohsawa,Masahiko, AU - Konishi,Yoshio, AU - Imanishi,Masahito, AU - Inoue,Takeshi, AU - Itabe,Hiroyuki, AU - Yoshiyama,Minoru, AU - Haze,Kazuo, AU - Becker,Anton E, AU - Ueda,Makiko, Y1 - 2013/04/29/ PY - 2013/5/1/entrez PY - 2013/5/1/pubmed PY - 2014/6/26/medline KW - atherosclerosis KW - end-stage renal disease KW - inflammation KW - oxidative stress SP - 557 EP - 67 JF - Hemodialysis international. International Symposium on Home Hemodialysis JO - Hemodial Int VL - 17 IS - 4 N2 - End-stage renal disease (ESRD) patients undergoing hemodialysis (HD) have a high prevalence of cardiovascular events. Low-density lipoprotein (LDL) in dialysis patients has been shown to be susceptible to in vitro peroxidation; therefore, oxidized-LDL (ox-LDL) could be generated in these patients. Moreover, myeloperoxidase (MPO) released from activated neutrophils may play a role in the induction of LDL oxidation. The purpose of this study was to investigate the relationship between plasma ox-LDL levels, plasma MPO levels, and serum high-sensitivity C-reactive protein (hs-CRP) levels during initial HD in patients with diabetic ESRD. Patients (n=28) had serial venous blood samples drawn before and after HD at the initial, second, and third sessions. Plasma ox-LDL levels were measured using a specific monoclonal antibody (DLH3), and plasma MPO levels were measured using an enzyme-linked immunosorbent assay kit. Plasma ox-LDL levels and MPO levels after a single HD session increased significantly (ox-LDL, P<0.005; MPO, P<0.0001) compared with levels before that HD session. However, the increase was transient since the levels returned to pre-HD session levels. Additionally, plasma MPO levels showed a positive correlation with plasma ox-LDL levels during HD (R=0.62, P=0.0029). No significant change was observed in serum hs-CRP levels before and after each HD session. This study demonstrates that plasma MPO levels are directly associated with plasma ox-LDL levels in diabetic ESRD patients during initial HD. These findings suggest a pivotal role for MPO and ox-LDL in the progression and acceleration of atherosclerosis in patients undergoing HD. SN - 1542-4758 UR - https://www.unboundmedicine.com/medline/citation/23627905/Positive_association_between_plasma_levels_of_oxidized_low_density_lipoprotein_and_myeloperoxidase_after_hemodialysis_in_patients_with_diabetic_end_stage_renal_disease_ L2 - https://doi.org/10.1111/hdi.12049 DB - PRIME DP - Unbound Medicine ER -