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5-Hydroxytryptamine 1A receptors inhibit glutamate release in rat medullary dorsal horn neurons.
Neuroreport. 2013 May 29; 24(8):399-403.N

Abstract

We examined 5-hydroxytryptamine 1A (5-HT1A) receptor-mediated modulation of glutamatergic transmission in rat medullary dorsal horn neurons using a conventional whole-cell patch clamp technique. 5-HT reversibly and concentration dependently decreased the amplitude of glutamatergic excitatory postsynaptic currents and increased the paired-pulse ratio, indicating that 5-HT acts presynaptically to reduce glutamate release from primary afferents. The 5-HT-induced inhibition of excitatory postsynaptic currents was partially occluded by NAN-190, a 5-HT1A receptor antagonist, and mimicked by 8-OH-DPAT, a 5-HT1A receptor agonist. Our results suggest that presynaptic 5-HT1A receptors inhibit glutamate release from trigeminal primary afferents onto medullary dorsal horn neurons, and thus in addition to other 5-HT1 receptor subtypes, 5-HT1A receptors could be a potential target for treatment of pain from orofacial tissues.

Authors+Show Affiliations

Department of Pharmacology, School of Dentistry, Kyungpook National University, Daegu, Republic of Korea.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23629688

Citation

Choi, In-Sun, et al. "5-Hydroxytryptamine 1A Receptors Inhibit Glutamate Release in Rat Medullary Dorsal Horn Neurons." Neuroreport, vol. 24, no. 8, 2013, pp. 399-403.
Choi IS, Cho JH, Jang IS. 5-Hydroxytryptamine 1A receptors inhibit glutamate release in rat medullary dorsal horn neurons. Neuroreport. 2013;24(8):399-403.
Choi, I. S., Cho, J. H., & Jang, I. S. (2013). 5-Hydroxytryptamine 1A receptors inhibit glutamate release in rat medullary dorsal horn neurons. Neuroreport, 24(8), 399-403. https://doi.org/10.1097/WNR.0b013e3283614cbf
Choi IS, Cho JH, Jang IS. 5-Hydroxytryptamine 1A Receptors Inhibit Glutamate Release in Rat Medullary Dorsal Horn Neurons. Neuroreport. 2013 May 29;24(8):399-403. PubMed PMID: 23629688.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 5-Hydroxytryptamine 1A receptors inhibit glutamate release in rat medullary dorsal horn neurons. AU - Choi,In-Sun, AU - Cho,Jin-Hwa, AU - Jang,Il-Sung, PY - 2013/5/1/entrez PY - 2013/5/1/pubmed PY - 2013/11/15/medline SP - 399 EP - 403 JF - Neuroreport JO - Neuroreport VL - 24 IS - 8 N2 - We examined 5-hydroxytryptamine 1A (5-HT1A) receptor-mediated modulation of glutamatergic transmission in rat medullary dorsal horn neurons using a conventional whole-cell patch clamp technique. 5-HT reversibly and concentration dependently decreased the amplitude of glutamatergic excitatory postsynaptic currents and increased the paired-pulse ratio, indicating that 5-HT acts presynaptically to reduce glutamate release from primary afferents. The 5-HT-induced inhibition of excitatory postsynaptic currents was partially occluded by NAN-190, a 5-HT1A receptor antagonist, and mimicked by 8-OH-DPAT, a 5-HT1A receptor agonist. Our results suggest that presynaptic 5-HT1A receptors inhibit glutamate release from trigeminal primary afferents onto medullary dorsal horn neurons, and thus in addition to other 5-HT1 receptor subtypes, 5-HT1A receptors could be a potential target for treatment of pain from orofacial tissues. SN - 1473-558X UR - https://www.unboundmedicine.com/medline/citation/23629688/5_Hydroxytryptamine_1A_receptors_inhibit_glutamate_release_in_rat_medullary_dorsal_horn_neurons_ L2 - http://dx.doi.org/10.1097/WNR.0b013e3283614cbf DB - PRIME DP - Unbound Medicine ER -