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High levels of dietary phytosterols affect lipid metabolism and increase liver and plasma TAG in Atlantic salmon (Salmo salar L.).
Br J Nutr 2013; 110(11):1958-67BJ

Abstract

Replacing dietary fishmeal (FM) and fish oil (FO) with plant ingredients in Atlantic salmon (Salmo salar L.) diets decreases dietary cholesterol and introduces phytosterols. The aim of the present study was to assess the effect of dietary sterol composition on cholesterol metabolism in Atlantic salmon. For this purpose, two dietary trials were performed, in which Atlantic salmon were fed either 100 % FM and FO (FM-FO) diet or one of the three diets with either high (80 %) or medium (40 %) plant protein (PP) and a high (70 %) or medium (35 %) vegetable oil (VO) blend (trial 1); or 70 % PP with either 100 % FO or 80 % of the FO replaced with olive, rapeseed or soyabean oil (trial 2). Replacing ≥ 70 % of FM with PP and ≥ 70 % of FO with either a VO blend or rapeseed oil increased plasma and liver TAG concentrations. These diets contained high levels of phytosterols and low levels of cholesterol. Fish fed low-cholesterol diets, but with less phytosterols, exhibited an increased expression of genes encoding proteins involved in cholesterol uptake and synthesis. The expression of these genes was, however, partially inhibited in rapeseed oil-fed fish possibly due to the high dietary and tissue phytosterol:cholesterol ratio. Atlantic salmon tissue and plasma cholesterol concentrations were maintained stable independent of the dietary sterol content.

Authors+Show Affiliations

National Institute of Nutrition and Seafood Research (NIFES), PO Box 2029, Strandgaten 229, 5817 Bergen, Norway.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23631850

Citation

Liland, Nina S., et al. "High Levels of Dietary Phytosterols Affect Lipid Metabolism and Increase Liver and Plasma TAG in Atlantic Salmon (Salmo Salar L.)." The British Journal of Nutrition, vol. 110, no. 11, 2013, pp. 1958-67.
Liland NS, Espe M, Rosenlund G, et al. High levels of dietary phytosterols affect lipid metabolism and increase liver and plasma TAG in Atlantic salmon (Salmo salar L.). Br J Nutr. 2013;110(11):1958-67.
Liland, N. S., Espe, M., Rosenlund, G., Waagbø, R., Hjelle, J. I., Lie, Ø., ... Torstensen, B. E. (2013). High levels of dietary phytosterols affect lipid metabolism and increase liver and plasma TAG in Atlantic salmon (Salmo salar L.). The British Journal of Nutrition, 110(11), pp. 1958-67. doi:10.1017/S0007114513001347.
Liland NS, et al. High Levels of Dietary Phytosterols Affect Lipid Metabolism and Increase Liver and Plasma TAG in Atlantic Salmon (Salmo Salar L.). Br J Nutr. 2013 Dec 14;110(11):1958-67. PubMed PMID: 23631850.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High levels of dietary phytosterols affect lipid metabolism and increase liver and plasma TAG in Atlantic salmon (Salmo salar L.). AU - Liland,Nina S, AU - Espe,Marit, AU - Rosenlund,Grethe, AU - Waagbø,Rune, AU - Hjelle,Jan I, AU - Lie,Øyvind, AU - Fontanillas,Ramon, AU - Torstensen,Bente E, Y1 - 2013/04/30/ PY - 2013/5/2/entrez PY - 2013/5/2/pubmed PY - 2014/1/28/medline SP - 1958 EP - 67 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 110 IS - 11 N2 - Replacing dietary fishmeal (FM) and fish oil (FO) with plant ingredients in Atlantic salmon (Salmo salar L.) diets decreases dietary cholesterol and introduces phytosterols. The aim of the present study was to assess the effect of dietary sterol composition on cholesterol metabolism in Atlantic salmon. For this purpose, two dietary trials were performed, in which Atlantic salmon were fed either 100 % FM and FO (FM-FO) diet or one of the three diets with either high (80 %) or medium (40 %) plant protein (PP) and a high (70 %) or medium (35 %) vegetable oil (VO) blend (trial 1); or 70 % PP with either 100 % FO or 80 % of the FO replaced with olive, rapeseed or soyabean oil (trial 2). Replacing ≥ 70 % of FM with PP and ≥ 70 % of FO with either a VO blend or rapeseed oil increased plasma and liver TAG concentrations. These diets contained high levels of phytosterols and low levels of cholesterol. Fish fed low-cholesterol diets, but with less phytosterols, exhibited an increased expression of genes encoding proteins involved in cholesterol uptake and synthesis. The expression of these genes was, however, partially inhibited in rapeseed oil-fed fish possibly due to the high dietary and tissue phytosterol:cholesterol ratio. Atlantic salmon tissue and plasma cholesterol concentrations were maintained stable independent of the dietary sterol content. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/23631850/High_levels_of_dietary_phytosterols_affect_lipid_metabolism_and_increase_liver_and_plasma_TAG_in_Atlantic_salmon__Salmo_salar_L___ L2 - https://www.cambridge.org/core/product/identifier/S0007114513001347/type/journal_article DB - PRIME DP - Unbound Medicine ER -