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Serum methylglyoxal level and its association with oxidative stress and disease severity in patients with psoriasis.

Abstract

Psoriasis vulgaris (PV), a chronic inflammatory skin disease, is a condition of increased oxidative stress (OxS). However, interest related to oxidative and carbonyl stress damages to proteins, such as the formation of advanced glycation end products (AGEs) and their precursor molecule methylglyoxal (MG) has been modest. The objective of this study was to compare the systemic levels of OxS markers in patients with PV and healthy controls (Co) and to investigate their correlation with the serum level of MG. Total peroxide concentration (TPX) and total antioxidant capacity (TAC) were estimated by means of spectrophotometry. The TPX and TAC ratio was regarded as OxS index (OSI). MG level was determined using ELISA. Compared to Co, patients with PV had significantly increased blood levels of TPX (P < 0.0001), OSI (P < 0.0001), and MG (P = 0.01), and lower TAC levels (P < 0.0001). Increase in body mass index (BMI) appeared to contribute to this imbalance as TAC levels decreased with increasing BMI (r = -0.252, P < 0.01). Increased TPX concentration was associated with higher serum level of MG (r = 0.610, P = 0.004), the latter being positively correlated with psoriasis area and severity index (r = 0.577, P = 0.008). In performed multivariate regression analysis, TPX, TAC, and OSI were all significant predictors of MG level. Our study gave further proof of increased systemic psoriasis-related OxS. MG serum level, reflecting simultaneously OxS as well as carbonyl stress status, could be used as a marker of disease activity in clinical trials while looking for new systemic therapies for psoriasis.

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  • Authors+Show Affiliations

    ,

    Clinic of Dermatology, University of Tartu, 31 Raja St, 50417, Tartu, Estonia. Sirje.Kaur@kliinikum.ee

    , ,

    Source

    Archives of dermatological research 305:6 2013 Aug pg 489-94

    MeSH

    Adult
    Antioxidants
    Biomarkers
    Case-Control Studies
    Enzyme-Linked Immunosorbent Assay
    Female
    Humans
    Male
    Middle Aged
    Multivariate Analysis
    Oxidative Stress
    Peroxides
    Protein Carbonylation
    Psoriasis
    Pyruvaldehyde
    Risk Factors
    Severity of Illness Index
    Spectrophotometry
    Young Adult

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    23636352

    Citation

    Kaur, Sirje, et al. "Serum Methylglyoxal Level and Its Association With Oxidative Stress and Disease Severity in Patients With Psoriasis." Archives of Dermatological Research, vol. 305, no. 6, 2013, pp. 489-94.
    Kaur S, Zilmer K, Leping V, et al. Serum methylglyoxal level and its association with oxidative stress and disease severity in patients with psoriasis. Arch Dermatol Res. 2013;305(6):489-94.
    Kaur, S., Zilmer, K., Leping, V., & Zilmer, M. (2013). Serum methylglyoxal level and its association with oxidative stress and disease severity in patients with psoriasis. Archives of Dermatological Research, 305(6), pp. 489-94. doi:10.1007/s00403-013-1362-5.
    Kaur S, et al. Serum Methylglyoxal Level and Its Association With Oxidative Stress and Disease Severity in Patients With Psoriasis. Arch Dermatol Res. 2013;305(6):489-94. PubMed PMID: 23636352.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Serum methylglyoxal level and its association with oxidative stress and disease severity in patients with psoriasis. AU - Kaur,Sirje, AU - Zilmer,Kersti, AU - Leping,Vambola, AU - Zilmer,Mihkel, Y1 - 2013/05/01/ PY - 2013/02/12/received PY - 2013/04/22/accepted PY - 2013/04/18/revised PY - 2013/5/3/entrez PY - 2013/5/3/pubmed PY - 2013/12/16/medline SP - 489 EP - 94 JF - Archives of dermatological research JO - Arch. Dermatol. Res. VL - 305 IS - 6 N2 - Psoriasis vulgaris (PV), a chronic inflammatory skin disease, is a condition of increased oxidative stress (OxS). However, interest related to oxidative and carbonyl stress damages to proteins, such as the formation of advanced glycation end products (AGEs) and their precursor molecule methylglyoxal (MG) has been modest. The objective of this study was to compare the systemic levels of OxS markers in patients with PV and healthy controls (Co) and to investigate their correlation with the serum level of MG. Total peroxide concentration (TPX) and total antioxidant capacity (TAC) were estimated by means of spectrophotometry. The TPX and TAC ratio was regarded as OxS index (OSI). MG level was determined using ELISA. Compared to Co, patients with PV had significantly increased blood levels of TPX (P < 0.0001), OSI (P < 0.0001), and MG (P = 0.01), and lower TAC levels (P < 0.0001). Increase in body mass index (BMI) appeared to contribute to this imbalance as TAC levels decreased with increasing BMI (r = -0.252, P < 0.01). Increased TPX concentration was associated with higher serum level of MG (r = 0.610, P = 0.004), the latter being positively correlated with psoriasis area and severity index (r = 0.577, P = 0.008). In performed multivariate regression analysis, TPX, TAC, and OSI were all significant predictors of MG level. Our study gave further proof of increased systemic psoriasis-related OxS. MG serum level, reflecting simultaneously OxS as well as carbonyl stress status, could be used as a marker of disease activity in clinical trials while looking for new systemic therapies for psoriasis. SN - 1432-069X UR - https://www.unboundmedicine.com/medline/citation/23636352/full_citation L2 - https://link.springer.com/article/10.1007/s00403-013-1362-5 DB - PRIME DP - Unbound Medicine ER -