Tags

Type your tag names separated by a space and hit enter

Scar management by means of occlusion and hydration: a comparative study of silicones versus a hydrating gel-cream.
Burns. 2013 Nov; 39(7):1437-48.B

Abstract

Despite the worldwide use of silicones in scar management, its exact working mechanism based on a balanced occlusion and hydration, is still not completely elucidated. Moreover, it seems peculiar that silicones with completely different occlusive and hydrating properties still could provide a similar therapeutic effect. The objective of the first part of this study was to compare the occlusive and hydrating properties of three fluid silicone gels and a hydrating gel-cream. In a second part of the study these results were compared with those of silicone gel sheets. Tape stripped skin was used as a standardized scar like model on both forearms of 40 healthy volunteers. At specific times, trans epidermal water loss (TEWL) and the hydration state of the stratum corneum were measured and compared with intact skin and a scar-like control over a 3-4h period. Our study clearly demonstrated that fluid silicone gels and a hydrating gel-cream have comparable occlusive and hydrating properties while silicone gel sheets are much more occlusive, reducing TEWL values far below those of normal skin. A well-balanced, hydrating gel-cream can provide the same occlusive and hydrating properties as fluid silicone gels, suggesting that it could eventually replace silicones in scar treatment.

Authors+Show Affiliations

Department of Plastic and Reconstructive Surgery - Burn Centre, Ghent University Hospital, Ghent, Belgium. Electronic address: hendrik.hoeksema@uzgent.be.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

23639224

Citation

Hoeksema, Henk, et al. "Scar Management By Means of Occlusion and Hydration: a Comparative Study of Silicones Versus a Hydrating Gel-cream." Burns : Journal of the International Society for Burn Injuries, vol. 39, no. 7, 2013, pp. 1437-48.
Hoeksema H, De Vos M, Verbelen J, et al. Scar management by means of occlusion and hydration: a comparative study of silicones versus a hydrating gel-cream. Burns. 2013;39(7):1437-48.
Hoeksema, H., De Vos, M., Verbelen, J., Pirayesh, A., & Monstrey, S. (2013). Scar management by means of occlusion and hydration: a comparative study of silicones versus a hydrating gel-cream. Burns : Journal of the International Society for Burn Injuries, 39(7), 1437-48. https://doi.org/10.1016/j.burns.2013.03.025
Hoeksema H, et al. Scar Management By Means of Occlusion and Hydration: a Comparative Study of Silicones Versus a Hydrating Gel-cream. Burns. 2013;39(7):1437-48. PubMed PMID: 23639224.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Scar management by means of occlusion and hydration: a comparative study of silicones versus a hydrating gel-cream. AU - Hoeksema,Henk, AU - De Vos,Marie, AU - Verbelen,Jozef, AU - Pirayesh,Ali, AU - Monstrey,Stan, Y1 - 2013/04/29/ PY - 2012/10/27/received PY - 2013/01/23/revised PY - 2013/03/29/accepted PY - 2013/5/4/entrez PY - 2013/5/4/pubmed PY - 2014/5/29/medline KW - Fluid silicone gel KW - Hydrating gel-cream KW - Hydration KW - Moisturizers KW - Occlusion KW - Scar KW - Scar treatment KW - Silicone KW - Silicone gel KW - Silicone gel sheets KW - Trans epidermal water loss SP - 1437 EP - 48 JF - Burns : journal of the International Society for Burn Injuries JO - Burns VL - 39 IS - 7 N2 - Despite the worldwide use of silicones in scar management, its exact working mechanism based on a balanced occlusion and hydration, is still not completely elucidated. Moreover, it seems peculiar that silicones with completely different occlusive and hydrating properties still could provide a similar therapeutic effect. The objective of the first part of this study was to compare the occlusive and hydrating properties of three fluid silicone gels and a hydrating gel-cream. In a second part of the study these results were compared with those of silicone gel sheets. Tape stripped skin was used as a standardized scar like model on both forearms of 40 healthy volunteers. At specific times, trans epidermal water loss (TEWL) and the hydration state of the stratum corneum were measured and compared with intact skin and a scar-like control over a 3-4h period. Our study clearly demonstrated that fluid silicone gels and a hydrating gel-cream have comparable occlusive and hydrating properties while silicone gel sheets are much more occlusive, reducing TEWL values far below those of normal skin. A well-balanced, hydrating gel-cream can provide the same occlusive and hydrating properties as fluid silicone gels, suggesting that it could eventually replace silicones in scar treatment. SN - 1879-1409 UR - https://www.unboundmedicine.com/medline/citation/23639224/Scar_management_by_means_of_occlusion_and_hydration:_a_comparative_study_of_silicones_versus_a_hydrating_gel_cream_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0305-4179(13)00105-8 DB - PRIME DP - Unbound Medicine ER -