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Neonatal sevoflurane anesthesia induces long-term memory impairment and decreases hippocampal PSD-95 expression without neuronal loss.
Eur Rev Med Pharmacol Sci. 2013 Apr; 17(7):941-50.ER

Abstract

AIM

Volatile anesthetics are widely used in the clinic, and sevoflurane is the most prevalent volatile anesthetic in pediatric anesthesia. Recent findings question the potential risks of volatile anesthetics on brain development. Evidence suggests that sevoflurane may cause neuronal deficiency. This study investigates the long-term effect of sevoflurane in the developing brain.

MATERIALS AND METHODS

We anesthetized 7 day-old rats for 4 h with 2.5% sevoflurane. A Morris water maze was used to evaluate hippocampal function 7 weeks after sevoflurane exposure. Nissl staining was performed to analyze neuronal loss. PSD-95 (postsynaptic density protein-95) expression in the hippocampus was measured using a western blot.

RESULTS

The exposure to 2.5% sevoflurane caused long-term deficits in hippocampal function and decreased hippocampal PSD-95 expression without neuronal loss. This study demonstrates that P7 rats exposed for 4 h to 2.5% sevoflurane have significant spatial learning and memory impairment 7 weeks after anesthesia. In addition, PSD-95 expression in the hippocampus decreased at P56 without neuronal loss.

CONCLUSIONS

These data suggest that sevoflurane causes neurotoxicity in the developing brain, which may be attributed to decreased PSD-95 in the hippocampus.

Authors+Show Affiliations

Department of Anesthesia, ZhongShan hospital, Fudan University, Shanghai, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23640442

Citation

Wang, S-Q, et al. "Neonatal Sevoflurane Anesthesia Induces Long-term Memory Impairment and Decreases Hippocampal PSD-95 Expression Without Neuronal Loss." European Review for Medical and Pharmacological Sciences, vol. 17, no. 7, 2013, pp. 941-50.
Wang SQ, Fang F, Xue ZG, et al. Neonatal sevoflurane anesthesia induces long-term memory impairment and decreases hippocampal PSD-95 expression without neuronal loss. Eur Rev Med Pharmacol Sci. 2013;17(7):941-50.
Wang, S. Q., Fang, F., Xue, Z. G., Cang, J., & Zhang, X. G. (2013). Neonatal sevoflurane anesthesia induces long-term memory impairment and decreases hippocampal PSD-95 expression without neuronal loss. European Review for Medical and Pharmacological Sciences, 17(7), 941-50.
Wang SQ, et al. Neonatal Sevoflurane Anesthesia Induces Long-term Memory Impairment and Decreases Hippocampal PSD-95 Expression Without Neuronal Loss. Eur Rev Med Pharmacol Sci. 2013;17(7):941-50. PubMed PMID: 23640442.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neonatal sevoflurane anesthesia induces long-term memory impairment and decreases hippocampal PSD-95 expression without neuronal loss. AU - Wang,S-Q, AU - Fang,F, AU - Xue,Z-G, AU - Cang,J, AU - Zhang,X-G, PY - 2013/5/4/entrez PY - 2013/5/4/pubmed PY - 2013/8/22/medline SP - 941 EP - 50 JF - European review for medical and pharmacological sciences JO - Eur Rev Med Pharmacol Sci VL - 17 IS - 7 N2 - AIM: Volatile anesthetics are widely used in the clinic, and sevoflurane is the most prevalent volatile anesthetic in pediatric anesthesia. Recent findings question the potential risks of volatile anesthetics on brain development. Evidence suggests that sevoflurane may cause neuronal deficiency. This study investigates the long-term effect of sevoflurane in the developing brain. MATERIALS AND METHODS: We anesthetized 7 day-old rats for 4 h with 2.5% sevoflurane. A Morris water maze was used to evaluate hippocampal function 7 weeks after sevoflurane exposure. Nissl staining was performed to analyze neuronal loss. PSD-95 (postsynaptic density protein-95) expression in the hippocampus was measured using a western blot. RESULTS: The exposure to 2.5% sevoflurane caused long-term deficits in hippocampal function and decreased hippocampal PSD-95 expression without neuronal loss. This study demonstrates that P7 rats exposed for 4 h to 2.5% sevoflurane have significant spatial learning and memory impairment 7 weeks after anesthesia. In addition, PSD-95 expression in the hippocampus decreased at P56 without neuronal loss. CONCLUSIONS: These data suggest that sevoflurane causes neurotoxicity in the developing brain, which may be attributed to decreased PSD-95 in the hippocampus. SN - 1128-3602 UR - https://www.unboundmedicine.com/medline/citation/23640442/Neonatal_sevoflurane_anesthesia_induces_long_term_memory_impairment_and_decreases_hippocampal_PSD_95_expression_without_neuronal_loss_ L2 - http://www.europeanreview.org/article/3694 DB - PRIME DP - Unbound Medicine ER -