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Cadmium exposure induces hematuria in Korean adults.
Environ Res. 2013 Jul; 124:23-7.ER

Abstract

INTRODUCTION

Toxic heavy metals have adverse effects on human health. However, the risk of hematuria caused by heavy metal exposure has not been evaluated.

METHODS

Data from 4701 Korean adults were obtained in the Korean National Health and Nutritional Examination Survey (2008-2010). Blood levels of the toxic heavy metals cadmium, lead, and mercury were measured. Hematuria was defined as a result of ≥+1 on a urine dipstick test. The odds ratios (ORs) for hematuria were measured according to the blood heavy metal levels after adjusting for multiple variables.

RESULTS

Individuals with blood cadmium levels in the 3rd and 4th quartiles had a greater OR for hematuria than those in the 1st quartile group: 3rd quartile, 1.35 (1.019-1.777; P=0.037); 4th quartile, 1.52 (1.140-2.017; P=0.004). When blood cadmium was considered as a log-transformed continuous variable, the correlation between blood cadmium and hematuria was significant: OR, 1.97 (1.224-3.160; Ptrend=0.005). In contrast, no significant correlations between hematuria and blood lead or mercury were found in the multivariate analyses.

DISCUSSION

The present study shows that high cadmium exposure is associated with a risk of hematuria.

Authors+Show Affiliations

Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110-744, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23642677

Citation

Han, Seung Seok, et al. "Cadmium Exposure Induces Hematuria in Korean Adults." Environmental Research, vol. 124, 2013, pp. 23-7.
Han SS, Kim M, Lee SM, et al. Cadmium exposure induces hematuria in Korean adults. Environ Res. 2013;124:23-7.
Han, S. S., Kim, M., Lee, S. M., Lee, J. P., Kim, S., Joo, K. W., Lim, C. S., Kim, Y. S., & Kim, D. K. (2013). Cadmium exposure induces hematuria in Korean adults. Environmental Research, 124, 23-7. https://doi.org/10.1016/j.envres.2013.04.001
Han SS, et al. Cadmium Exposure Induces Hematuria in Korean Adults. Environ Res. 2013;124:23-7. PubMed PMID: 23642677.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cadmium exposure induces hematuria in Korean adults. AU - Han,Seung Seok, AU - Kim,Myounghee, AU - Lee,Su Mi, AU - Lee,Jung Pyo, AU - Kim,Sejoong, AU - Joo,Kwon Wook, AU - Lim,Chun Soo, AU - Kim,Yon Su, AU - Kim,Dong Ki, Y1 - 2013/05/02/ PY - 2012/12/27/received PY - 2013/03/15/revised PY - 2013/04/09/accepted PY - 2013/5/7/entrez PY - 2013/5/7/pubmed PY - 2013/8/14/medline SP - 23 EP - 7 JF - Environmental research JO - Environ Res VL - 124 N2 - INTRODUCTION: Toxic heavy metals have adverse effects on human health. However, the risk of hematuria caused by heavy metal exposure has not been evaluated. METHODS: Data from 4701 Korean adults were obtained in the Korean National Health and Nutritional Examination Survey (2008-2010). Blood levels of the toxic heavy metals cadmium, lead, and mercury were measured. Hematuria was defined as a result of ≥+1 on a urine dipstick test. The odds ratios (ORs) for hematuria were measured according to the blood heavy metal levels after adjusting for multiple variables. RESULTS: Individuals with blood cadmium levels in the 3rd and 4th quartiles had a greater OR for hematuria than those in the 1st quartile group: 3rd quartile, 1.35 (1.019-1.777; P=0.037); 4th quartile, 1.52 (1.140-2.017; P=0.004). When blood cadmium was considered as a log-transformed continuous variable, the correlation between blood cadmium and hematuria was significant: OR, 1.97 (1.224-3.160; Ptrend=0.005). In contrast, no significant correlations between hematuria and blood lead or mercury were found in the multivariate analyses. DISCUSSION: The present study shows that high cadmium exposure is associated with a risk of hematuria. SN - 1096-0953 UR - https://www.unboundmedicine.com/medline/citation/23642677/Cadmium_exposure_induces_hematuria_in_Korean_adults_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0013-9351(13)00070-4 DB - PRIME DP - Unbound Medicine ER -