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Liver enzymes and vitamin D levels in metabolically healthy but obese individuals: Korean National Health and Nutrition Examination Survey.
Metabolism. 2013 Sep; 62(9):1305-12.M

Abstract

OBJECTIVE

Increased liver enzymes and decreased vitamin D levels are associated with insulin resistance and type 2 diabetes. We examined liver enzymes and vitamin D levels in metabolically healthy but obese (MHO) individuals and compared the values with those of other body size phenotypes in the Korean population.

MATERIALS/METHODS

A total of 16,190 people over the age of 18years were analyzed using data from the Fourth Korean National Health and Nutrition Examination Survey, which is a nationally representative survey. Body size phenotypes were classified into four groups by body mass index (BMI) and number of metabolic syndrome components.

RESULTS

The prevalence of MHO was 14.9% in the entire population and 47.7% in the obese population. In a correlation analysis adjusted for age, sex, and BMI, AST and ALT levels were positively correlated with insulin resistance and cardiometabolic risk factors of the metabolic syndrome, whereas vitamin D level was negatively correlated with these variables. MHO individuals had significantly lower concentrations of AST and ALT compared to metabolically abnormal obese (MAO) subjects, although vitamin D levels were not significantly different. Furthermore, a multiple logistic regression analysis revealed that MHO individuals had lower risk of liver enzyme abnormality compared to MAO after adjusting for potential confounding factors. However, the risk of vitamin D deficiency was not significantly different among groups with different body size phenotypes.

CONCLUSIONS

Although both liver enzymes and vitamin D levels are related to insulin resistance and metabolic syndrome, only liver enzymes were independently associated with MHO phenotype.

Authors+Show Affiliations

Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Korea University, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23643404

Citation

Hong, Ho Cheol, et al. "Liver Enzymes and Vitamin D Levels in Metabolically Healthy but Obese Individuals: Korean National Health and Nutrition Examination Survey." Metabolism: Clinical and Experimental, vol. 62, no. 9, 2013, pp. 1305-12.
Hong HC, Lee JS, Choi HY, et al. Liver enzymes and vitamin D levels in metabolically healthy but obese individuals: Korean National Health and Nutrition Examination Survey. Metabolism. 2013;62(9):1305-12.
Hong, H. C., Lee, J. S., Choi, H. Y., Yang, S. J., Yoo, H. J., Seo, J. A., Kim, S. G., Kim, N. H., Baik, S. H., Choi, D. S., & Choi, K. M. (2013). Liver enzymes and vitamin D levels in metabolically healthy but obese individuals: Korean National Health and Nutrition Examination Survey. Metabolism: Clinical and Experimental, 62(9), 1305-12. https://doi.org/10.1016/j.metabol.2013.04.002
Hong HC, et al. Liver Enzymes and Vitamin D Levels in Metabolically Healthy but Obese Individuals: Korean National Health and Nutrition Examination Survey. Metabolism. 2013;62(9):1305-12. PubMed PMID: 23643404.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Liver enzymes and vitamin D levels in metabolically healthy but obese individuals: Korean National Health and Nutrition Examination Survey. AU - Hong,Ho Cheol, AU - Lee,Ji-Sung, AU - Choi,Hae Yoon, AU - Yang,Sae Jeong, AU - Yoo,Hye Jin, AU - Seo,Ji A, AU - Kim,Sin Gon, AU - Kim,Nan Hee, AU - Baik,Sei Hyun, AU - Choi,Dong Seop, AU - Choi,Kyung Mook, Y1 - 2013/05/02/ PY - 2012/10/27/received PY - 2013/03/22/revised PY - 2013/04/02/accepted PY - 2013/5/7/entrez PY - 2013/5/7/pubmed PY - 2013/10/24/medline KW - 25(OH)D KW - 25-hydroxyvitamin D KW - BMI KW - Body mass index KW - Body size phenotype KW - CI KW - CVD KW - Cardiovascular disease KW - Confidence interval KW - Fourth Korean National Health and Nutrition Examination Survey KW - KNHANES IV KW - MAO KW - MHO KW - Metabolically abnormal obese KW - Metabolically healthy but obese KW - NAFLD KW - NHANES III KW - Nonalcoholic fatty liver disease KW - OR KW - Obesity metabolism KW - Odds ratio KW - Third National Health and Nutrition Examination Survey in the United States KW - Vitamin D SP - 1305 EP - 12 JF - Metabolism: clinical and experimental JO - Metabolism VL - 62 IS - 9 N2 - OBJECTIVE: Increased liver enzymes and decreased vitamin D levels are associated with insulin resistance and type 2 diabetes. We examined liver enzymes and vitamin D levels in metabolically healthy but obese (MHO) individuals and compared the values with those of other body size phenotypes in the Korean population. MATERIALS/METHODS: A total of 16,190 people over the age of 18years were analyzed using data from the Fourth Korean National Health and Nutrition Examination Survey, which is a nationally representative survey. Body size phenotypes were classified into four groups by body mass index (BMI) and number of metabolic syndrome components. RESULTS: The prevalence of MHO was 14.9% in the entire population and 47.7% in the obese population. In a correlation analysis adjusted for age, sex, and BMI, AST and ALT levels were positively correlated with insulin resistance and cardiometabolic risk factors of the metabolic syndrome, whereas vitamin D level was negatively correlated with these variables. MHO individuals had significantly lower concentrations of AST and ALT compared to metabolically abnormal obese (MAO) subjects, although vitamin D levels were not significantly different. Furthermore, a multiple logistic regression analysis revealed that MHO individuals had lower risk of liver enzyme abnormality compared to MAO after adjusting for potential confounding factors. However, the risk of vitamin D deficiency was not significantly different among groups with different body size phenotypes. CONCLUSIONS: Although both liver enzymes and vitamin D levels are related to insulin resistance and metabolic syndrome, only liver enzymes were independently associated with MHO phenotype. SN - 1532-8600 UR - https://www.unboundmedicine.com/medline/citation/23643404/Liver_enzymes_and_vitamin_D_levels_in_metabolically_healthy_but_obese_individuals:_Korean_National_Health_and_Nutrition_Examination_Survey_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(13)00099-1 DB - PRIME DP - Unbound Medicine ER -