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Lack of association between brain-derived neurotrophic factor Val66Met polymorphism and body mass index change over time in healthy adults.
Neurosci Lett 2013; 545:127-31NL

Abstract

Obesity is becoming the epidemic health problem worldwide with a very complex etiology. The interaction between diverse genetic and environmental factors contributes to development of obesity. Among myriad of functions in central and peripheral tissues, brain-derived neurotrophic factor (BDNF) also regulates energy homeostasis, food intake and feeding behavior, and has a role in obesity and increased body mass index (BMI). BDNF Val66Met (rs6265) polymorphism is associated with BMI gain, but both positive associations and non-replications are reported. Since BMI changes over time and since genetic influences on BMI vary with age, the aim of the study was to evaluate association between BDNF Val66Met polymorphism and BMI gain in healthy subjects with middle or old age. The study included a cohort of 339 adult healthy Caucasians of Croatian origin, free of eating and metabolic disorders, evaluated in three time periods in the year 1972, 1982 and 2006, when the subjects were around 40, 50 and 70 years old, respectively. The results revealed a significant effect of smoking on BMI, but a lack of significant association between BDNF Val66Met polymorphism and overweight or obesity, and no significant association between BDNF Val66Met and BMI changes over time. These results did not confirm the major role of BDNF Val66Met in the regulation of BMI changes in adult and old healthy subjects.

Authors+Show Affiliations

Division of Molecular Medicine, Rudjer Boskovic Institute, Bijenicka 54, HR-10000 Zagreb, Croatia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23643991

Citation

Nikolac Perkovic, Matea, et al. "Lack of Association Between Brain-derived Neurotrophic Factor Val66Met Polymorphism and Body Mass Index Change Over Time in Healthy Adults." Neuroscience Letters, vol. 545, 2013, pp. 127-31.
Nikolac Perkovic M, Mustapic M, Pavlovic M, et al. Lack of association between brain-derived neurotrophic factor Val66Met polymorphism and body mass index change over time in healthy adults. Neurosci Lett. 2013;545:127-31.
Nikolac Perkovic, M., Mustapic, M., Pavlovic, M., Uzun, S., Kozumplik, O., Barisic, I., ... Pivac, N. (2013). Lack of association between brain-derived neurotrophic factor Val66Met polymorphism and body mass index change over time in healthy adults. Neuroscience Letters, 545, pp. 127-31. doi:10.1016/j.neulet.2013.04.036.
Nikolac Perkovic M, et al. Lack of Association Between Brain-derived Neurotrophic Factor Val66Met Polymorphism and Body Mass Index Change Over Time in Healthy Adults. Neurosci Lett. 2013 Jun 17;545:127-31. PubMed PMID: 23643991.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lack of association between brain-derived neurotrophic factor Val66Met polymorphism and body mass index change over time in healthy adults. AU - Nikolac Perkovic,Matea, AU - Mustapic,Maja, AU - Pavlovic,Mladen, AU - Uzun,Suzana, AU - Kozumplik,Oliver, AU - Barisic,Ivan, AU - Muck-Seler,Dorotea, AU - Pivac,Nela, Y1 - 2013/05/02/ PY - 2013/02/27/received PY - 2013/04/12/revised PY - 2013/04/24/accepted PY - 2013/5/7/entrez PY - 2013/5/7/pubmed PY - 2014/1/7/medline SP - 127 EP - 31 JF - Neuroscience letters JO - Neurosci. Lett. VL - 545 N2 - Obesity is becoming the epidemic health problem worldwide with a very complex etiology. The interaction between diverse genetic and environmental factors contributes to development of obesity. Among myriad of functions in central and peripheral tissues, brain-derived neurotrophic factor (BDNF) also regulates energy homeostasis, food intake and feeding behavior, and has a role in obesity and increased body mass index (BMI). BDNF Val66Met (rs6265) polymorphism is associated with BMI gain, but both positive associations and non-replications are reported. Since BMI changes over time and since genetic influences on BMI vary with age, the aim of the study was to evaluate association between BDNF Val66Met polymorphism and BMI gain in healthy subjects with middle or old age. The study included a cohort of 339 adult healthy Caucasians of Croatian origin, free of eating and metabolic disorders, evaluated in three time periods in the year 1972, 1982 and 2006, when the subjects were around 40, 50 and 70 years old, respectively. The results revealed a significant effect of smoking on BMI, but a lack of significant association between BDNF Val66Met polymorphism and overweight or obesity, and no significant association between BDNF Val66Met and BMI changes over time. These results did not confirm the major role of BDNF Val66Met in the regulation of BMI changes in adult and old healthy subjects. SN - 1872-7972 UR - https://www.unboundmedicine.com/medline/citation/23643991/Lack_of_association_between_brain_derived_neurotrophic_factor_Val66Met_polymorphism_and_body_mass_index_change_over_time_in_healthy_adults_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(13)00395-9 DB - PRIME DP - Unbound Medicine ER -