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Leprosy in a rheumatology setting: a challenging mimic to expose.
Clin Rheumatol 2013; 32(10):1557-63CR

Abstract

Leprosy can manifest arthritis both as a complication and a comorbid disorder and can be a challenging differential diagnosis in rheumatology practice due to several common features. Uncommonly, it may present as acute severe polyarthritis with skin lesions and neurological deficit or a digital vasculitis and gangrene. We demonstrate this profile in a retrospective case series analysis of 33 patients (13 females, median age 55 years) in a community-based clinic setting over the period 1998-2012; an electronic search of case records of 41,000 patients was carried out. Rheumatoid arthritis (RA) coexisted in seven patients (three lepromatous, two tuberculoid, and two polyneuritic). Serological rheumatoid factor and antinuclear antibody were often false positive. Several patients of RA were on long-term supervised methotrexate. Rheumatologists should be aware of this clinical mimic to avoid errors in diagnosis and management.

Authors+Show Affiliations

Department of Physiology, Bharati Vidyapeeth Medical College, NIBM Road, 10 Memory Garden, Kondhwa, Pune, 411048, India, shslvi@gmail.com.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23645094

Citation

Salvi, Sheetal, and Arvind Chopra. "Leprosy in a Rheumatology Setting: a Challenging Mimic to Expose." Clinical Rheumatology, vol. 32, no. 10, 2013, pp. 1557-63.
Salvi S, Chopra A. Leprosy in a rheumatology setting: a challenging mimic to expose. Clin Rheumatol. 2013;32(10):1557-63.
Salvi, S., & Chopra, A. (2013). Leprosy in a rheumatology setting: a challenging mimic to expose. Clinical Rheumatology, 32(10), pp. 1557-63. doi:10.1007/s10067-013-2276-5.
Salvi S, Chopra A. Leprosy in a Rheumatology Setting: a Challenging Mimic to Expose. Clin Rheumatol. 2013;32(10):1557-63. PubMed PMID: 23645094.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Leprosy in a rheumatology setting: a challenging mimic to expose. AU - Salvi,Sheetal, AU - Chopra,Arvind, Y1 - 2013/05/07/ PY - 2013/03/25/received PY - 2013/04/19/accepted PY - 2013/5/7/entrez PY - 2013/5/7/pubmed PY - 2014/5/7/medline SP - 1557 EP - 63 JF - Clinical rheumatology JO - Clin. Rheumatol. VL - 32 IS - 10 N2 - Leprosy can manifest arthritis both as a complication and a comorbid disorder and can be a challenging differential diagnosis in rheumatology practice due to several common features. Uncommonly, it may present as acute severe polyarthritis with skin lesions and neurological deficit or a digital vasculitis and gangrene. We demonstrate this profile in a retrospective case series analysis of 33 patients (13 females, median age 55 years) in a community-based clinic setting over the period 1998-2012; an electronic search of case records of 41,000 patients was carried out. Rheumatoid arthritis (RA) coexisted in seven patients (three lepromatous, two tuberculoid, and two polyneuritic). Serological rheumatoid factor and antinuclear antibody were often false positive. Several patients of RA were on long-term supervised methotrexate. Rheumatologists should be aware of this clinical mimic to avoid errors in diagnosis and management. SN - 1434-9949 UR - https://www.unboundmedicine.com/medline/citation/23645094/Leprosy_in_a_rheumatology_setting:_a_challenging_mimic_to_expose L2 - https://dx.doi.org/10.1007/s10067-013-2276-5 DB - PRIME DP - Unbound Medicine ER -