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Elevated fasting glucose levels within normal range are associated with an increased risk of metabolic syndrome in older women.

Abstract

OBJECTIVE

The prevalence of cardiovascular disease (CVD) and metabolic syndrome (MetS) increases with increasing fasting plasma glucose (FPG) levels in an elderly population with pre-diabetes or diabetes. However, it remains unknown whether the relationship between elevated FPG and increased risks of MetS exists in older women with normoglycemia (FPG<100mg/dL). Therefore, the present study was conducted to fill the lack of information in that area.

MATERIALS AND METHODS

We included 6505 apparently healthy women, aged 65years and older, with normoglycemia who participated in routine health checkups at health screening centers in Taiwan. Components of MetS (FPG, waist circumference (WC), high-density lipoprotein cholesterol (HDL-C), triglycerides, and systolic/diastolic blood pressure), body mass index (BMI), low-density lipoprotein cholesterol (LDL-C), total cholesterol, and percentage body fat (PBF) were examined in all subjects.

RESULTS

Subjects were sub-grouped by FPG levels (<90mg/dL, 91-95mg/dL and >95mg/dL for group 1, group 2 and group 3, respectively). Subjects in group 2 and group 3 were 1.22-fold (P=0.017) and 1.25-fold (P=0.007) more likely to have MetS compared with those in group 1. Age, WC, BMI, PBF, systolic and diastolic blood pressure, total cholesterol, triglycerides, and HDL-C were significantly correlated with FPG, whereas HDL-C was negatively correlated with FPG. In a multivariate stepwise regression analysis, PBF, LDL-C, triglycerides, and age were significantly and independently associated with FPG.

CONCLUSION

Among older women, the risk of MetS was significantly associated with elevated FPG even for subjects with normal FPG. Lifestyle interventions for reducing PBF and controlling dyslipidemia could help reduce the risk of MetS in this population.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

    , , , , , ,

    Source

    MeSH

    Age Distribution
    Aged
    Aged, 80 and over
    Blood Glucose
    Cholesterol, HDL
    Cholesterol, LDL
    Fasting
    Female
    Humans
    Metabolic Syndrome
    Prevalence
    Reference Values
    Risk Factors
    Triglycerides

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    23647841

    Citation

    Hsiao, Fone-Ching, et al. "Elevated Fasting Glucose Levels Within Normal Range Are Associated With an Increased Risk of Metabolic Syndrome in Older Women." European Journal of Internal Medicine, vol. 24, no. 5, 2013, pp. 425-9.
    Hsiao FC, Hsieh CH, Wu CZ, et al. Elevated fasting glucose levels within normal range are associated with an increased risk of metabolic syndrome in older women. Eur J Intern Med. 2013;24(5):425-9.
    Hsiao, F. C., Hsieh, C. H., Wu, C. Z., Hsu, C. H., Lin, J. D., Lee, T. I., ... Chen, Y. L. (2013). Elevated fasting glucose levels within normal range are associated with an increased risk of metabolic syndrome in older women. European Journal of Internal Medicine, 24(5), pp. 425-9. doi:10.1016/j.ejim.2013.03.013.
    Hsiao FC, et al. Elevated Fasting Glucose Levels Within Normal Range Are Associated With an Increased Risk of Metabolic Syndrome in Older Women. Eur J Intern Med. 2013;24(5):425-9. PubMed PMID: 23647841.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Elevated fasting glucose levels within normal range are associated with an increased risk of metabolic syndrome in older women. AU - Hsiao,Fone-Ching, AU - Hsieh,Chang-Hsun, AU - Wu,Chung-Ze, AU - Hsu,Chun-Hsien, AU - Lin,Jiunn-Diann, AU - Lee,Ting-I, AU - Pei,Dee, AU - Chen,Yen-Lin, Y1 - 2013/05/03/ PY - 2012/12/23/received PY - 2013/03/19/revised PY - 2013/03/21/accepted PY - 2013/5/8/entrez PY - 2013/5/8/pubmed PY - 2014/2/12/medline SP - 425 EP - 9 JF - European journal of internal medicine JO - Eur. J. Intern. Med. VL - 24 IS - 5 N2 - OBJECTIVE: The prevalence of cardiovascular disease (CVD) and metabolic syndrome (MetS) increases with increasing fasting plasma glucose (FPG) levels in an elderly population with pre-diabetes or diabetes. However, it remains unknown whether the relationship between elevated FPG and increased risks of MetS exists in older women with normoglycemia (FPG<100mg/dL). Therefore, the present study was conducted to fill the lack of information in that area. MATERIALS AND METHODS: We included 6505 apparently healthy women, aged 65years and older, with normoglycemia who participated in routine health checkups at health screening centers in Taiwan. Components of MetS (FPG, waist circumference (WC), high-density lipoprotein cholesterol (HDL-C), triglycerides, and systolic/diastolic blood pressure), body mass index (BMI), low-density lipoprotein cholesterol (LDL-C), total cholesterol, and percentage body fat (PBF) were examined in all subjects. RESULTS: Subjects were sub-grouped by FPG levels (<90mg/dL, 91-95mg/dL and >95mg/dL for group 1, group 2 and group 3, respectively). Subjects in group 2 and group 3 were 1.22-fold (P=0.017) and 1.25-fold (P=0.007) more likely to have MetS compared with those in group 1. Age, WC, BMI, PBF, systolic and diastolic blood pressure, total cholesterol, triglycerides, and HDL-C were significantly correlated with FPG, whereas HDL-C was negatively correlated with FPG. In a multivariate stepwise regression analysis, PBF, LDL-C, triglycerides, and age were significantly and independently associated with FPG. CONCLUSION: Among older women, the risk of MetS was significantly associated with elevated FPG even for subjects with normal FPG. Lifestyle interventions for reducing PBF and controlling dyslipidemia could help reduce the risk of MetS in this population. SN - 1879-0828 UR - https://www.unboundmedicine.com/medline/citation/23647841/Elevated_fasting_glucose_levels_within_normal_range_are_associated_with_an_increased_risk_of_metabolic_syndrome_in_older_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0953-6205(13)00097-6 DB - PRIME DP - Unbound Medicine ER -