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Incidence of multiple sclerosis in multiple racial and ethnic groups.
Neurology 2013; 80(19):1734-9Neur

Abstract

OBJECTIVE

To determine whether the incidence of multiple sclerosis (MS) varies by race/ethnicity in a multiethnic, population-based cohort.

METHODS

We conducted a retrospective cohort study of more than 9 million person-years of observation from the multiethnic, community-dwelling members of Kaiser Permanente Southern California health plan from January 1, 2008 to December 31, 2010. Incidence of MS and risk ratios comparing incidence rates between racial/ethnic groups were calculated using Poisson regression.

RESULTS

We identified 496 patients newly diagnosed with MS who met McDonald criteria. The average age at diagnosis was 41.6 years (range 8.6-78.3 years) and 70.2% were women. The female preponderance was more pronounced among black (79.3%) than white, Hispanic, and Asian individuals with MS (67.8%, 68.1%, and 69.2%, respectively; p = 0.03). The incidence of MS was higher in blacks (10.2, 95% confidence interval [CI] 8.4-12.4; p < 0.0001) and lower in Hispanics (2.9, 95% CI 2.4-3.5; p < 0.0001) and Asians (1.4, 95% CI 0.7-2.4; p < 0.0001) than whites (6.9, 95% CI 6.1-7.8). Black women had a higher risk of MS (risk ratio 1.59, 95% CI 1.27-1.99; p = 0.0005) whereas black men had a similar risk of MS (risk ratio 1.04, 95% CI = 0.67-1.57) compared with whites.

CONCLUSIONS

Our findings do not support the widely accepted assertion that blacks have a lower risk of MS than whites. A possible explanation for our findings is that people with darker skin tones have lower vitamin D levels and thereby an increased risk of MS, but this would not explain why Hispanics and Asians have a lower risk of MS than whites or why the higher risk of MS among blacks was found only among women.

Authors+Show Affiliations

Department of Research and Evaluation, Kaiser Permanente, Southern California, Pasadena, CA, USA. Annette.M.Langer-Gould@kp.orgNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23650231

Citation

Langer-Gould, Annette, et al. "Incidence of Multiple Sclerosis in Multiple Racial and Ethnic Groups." Neurology, vol. 80, no. 19, 2013, pp. 1734-9.
Langer-Gould A, Brara SM, Beaber BE, et al. Incidence of multiple sclerosis in multiple racial and ethnic groups. Neurology. 2013;80(19):1734-9.
Langer-Gould, A., Brara, S. M., Beaber, B. E., & Zhang, J. L. (2013). Incidence of multiple sclerosis in multiple racial and ethnic groups. Neurology, 80(19), pp. 1734-9. doi:10.1212/WNL.0b013e3182918cc2.
Langer-Gould A, et al. Incidence of Multiple Sclerosis in Multiple Racial and Ethnic Groups. Neurology. 2013 May 7;80(19):1734-9. PubMed PMID: 23650231.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Incidence of multiple sclerosis in multiple racial and ethnic groups. AU - Langer-Gould,Annette, AU - Brara,Sonu M, AU - Beaber,Brandon E, AU - Zhang,Jian L, PY - 2013/5/8/entrez PY - 2013/5/8/pubmed PY - 2013/7/3/medline SP - 1734 EP - 9 JF - Neurology JO - Neurology VL - 80 IS - 19 N2 - OBJECTIVE: To determine whether the incidence of multiple sclerosis (MS) varies by race/ethnicity in a multiethnic, population-based cohort. METHODS: We conducted a retrospective cohort study of more than 9 million person-years of observation from the multiethnic, community-dwelling members of Kaiser Permanente Southern California health plan from January 1, 2008 to December 31, 2010. Incidence of MS and risk ratios comparing incidence rates between racial/ethnic groups were calculated using Poisson regression. RESULTS: We identified 496 patients newly diagnosed with MS who met McDonald criteria. The average age at diagnosis was 41.6 years (range 8.6-78.3 years) and 70.2% were women. The female preponderance was more pronounced among black (79.3%) than white, Hispanic, and Asian individuals with MS (67.8%, 68.1%, and 69.2%, respectively; p = 0.03). The incidence of MS was higher in blacks (10.2, 95% confidence interval [CI] 8.4-12.4; p < 0.0001) and lower in Hispanics (2.9, 95% CI 2.4-3.5; p < 0.0001) and Asians (1.4, 95% CI 0.7-2.4; p < 0.0001) than whites (6.9, 95% CI 6.1-7.8). Black women had a higher risk of MS (risk ratio 1.59, 95% CI 1.27-1.99; p = 0.0005) whereas black men had a similar risk of MS (risk ratio 1.04, 95% CI = 0.67-1.57) compared with whites. CONCLUSIONS: Our findings do not support the widely accepted assertion that blacks have a lower risk of MS than whites. A possible explanation for our findings is that people with darker skin tones have lower vitamin D levels and thereby an increased risk of MS, but this would not explain why Hispanics and Asians have a lower risk of MS than whites or why the higher risk of MS among blacks was found only among women. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/23650231/Incidence_of_multiple_sclerosis_in_multiple_racial_and_ethnic_groups_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&amp;pmid=23650231 DB - PRIME DP - Unbound Medicine ER -