Tags

Type your tag names separated by a space and hit enter

[Electroacupuncture intervention improved changes of skin barrier and color in type 2 diabetes rats].
Zhen Ci Yan Jiu. 2013 Feb; 38(1):7-13.ZC

Abstract

OBJECTIVE

To observe the effect of electroacupuncture (EA) of auricular concha region (ACR), "Zusanli" (ST 36) and "Sanyinjiao"(SP 6) on abnormal skin barrier and color in streptozotocin (STZ)-induced type 2 diabetes mellitus (T 2 DM) rats so as to find a better therapeutic method.

METHODS

Fifty male Sprague Dawley (SD) rats were randomized into control (n = 10), model (n = 13), EA-ST 36-SP 6 (n = 14) and EA-ACR (n = 13) groups. T 2 DM model was established by intraperitoneal injection of 1% STZ (50 mg/kg) and by feeding the animals with high-fat diet for 30 days. EA (15 Hz, 1 mA) was applied to bilateral "Zusanli" (ST 36), "Sanyinjiao" (SP 6) and ACR respectively for 30 min, once daily for 14 days. Multi Probe Adapter 9 skin measurement system (MPA 9) was used to measure the stratum corneum hydration (SCH), transepidermal water loss (TEWL), erythema index (El), melanin index (MI) and chromatic aberration values (L. a. b.) of the abdomenal and back (L1 - L6) skin, respectively.

RESULTS

In comparison with the control group and pre-modeling, blood glucose contents of the model, EA-ST 36-SP 6 and EA-ACR groups were increased significantly (P < 0.01) after modeling. Compared with the model group, blood glucose levels of both EA-ST 36-SP 6 and EA-ACR groups were down-regulated apparently (P < 0.01) after treatment. Thirty days after modeling, the SCH, TEWL, EI, MI, L. and a. levels of the back skin, and the SCH and L. levels of the abdominal skin were decreased significantly (P < 0.05), while the level of b. in the back skin, and those of TEWL, EL, a. and b. of the abdominal skin increased considerably in the model group (P < 0.05). After EA, the levels of SCH, TEWL MI, L. a. and b. in the EA-ST 36-SP 6 group, SCH, TEWL, L. and b. in the EA-ACR group of the back skin, and SCH, L. and b. of both EAST 36-SP 6 and EA-ACR groups, as well as EI and a. of the EA-ST 36-SP 6 group of the abdominal skin were reversed remarkably (P < 0.05). No significant differences were found between the EA-ST 36-SP 6 and model groups in the levels of El of the back skin, TEWL and MI of the abdominal skin, and between the EA-ACR and model groups in the levels of SCH, EI, MI and a. of the back skin, and TEWL, EI, MI and a. of the abdominal skin (P > 0.05). In spite of a mildly better therapeutic effect of EA-ST 36-SP 6 in regulating some of the abovementioned indexes, no significant differences were found between the two EA groups in all the indexes (P > 0.05).

CONCLUSION

EA of both ST 36-SP 6 and ACR can effectively down-regulate blood glucose level, suppress DM-induced decrease of SCH, TEWL, L. and a. of the back skin, and SCH of the abdominal skin, and down-regulate b. levels of the back and abdominal skin in T 2 DM rats, showing an improvement of the impaired skin barrier and color changes following EA intervention.

Authors+Show Affiliations

Institute of Acu-moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China. jameszhai34@163.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

23650793

Citation

Zhai, Xu, et al. "[Electroacupuncture Intervention Improved Changes of Skin Barrier and Color in Type 2 Diabetes Rats]." Zhen Ci Yan Jiu = Acupuncture Research, vol. 38, no. 1, 2013, pp. 7-13.
Zhai X, Rong PJ, Wang HC, et al. [Electroacupuncture intervention improved changes of skin barrier and color in type 2 diabetes rats]. Zhen Ci Yan Jiu. 2013;38(1):7-13.
Zhai, X., Rong, P. J., Wang, H. C., Li, S. Y., Meng, H., He, M. D., Huang, F., Wang, X., & Song, J. (2013). [Electroacupuncture intervention improved changes of skin barrier and color in type 2 diabetes rats]. Zhen Ci Yan Jiu = Acupuncture Research, 38(1), 7-13.
Zhai X, et al. [Electroacupuncture Intervention Improved Changes of Skin Barrier and Color in Type 2 Diabetes Rats]. Zhen Ci Yan Jiu. 2013;38(1):7-13. PubMed PMID: 23650793.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Electroacupuncture intervention improved changes of skin barrier and color in type 2 diabetes rats]. AU - Zhai,Xu, AU - Rong,Pei-Jing, AU - Wang,Hong-Cai, AU - Li,Shao-Yuan, AU - Meng,Hong, AU - He,Meng-Dong, AU - Huang,Feng, AU - Wang,Xia, AU - Song,Jie, PY - 2013/5/9/entrez PY - 2013/5/9/pubmed PY - 2013/7/3/medline SP - 7 EP - 13 JF - Zhen ci yan jiu = Acupuncture research JO - Zhen Ci Yan Jiu VL - 38 IS - 1 N2 - OBJECTIVE: To observe the effect of electroacupuncture (EA) of auricular concha region (ACR), "Zusanli" (ST 36) and "Sanyinjiao"(SP 6) on abnormal skin barrier and color in streptozotocin (STZ)-induced type 2 diabetes mellitus (T 2 DM) rats so as to find a better therapeutic method. METHODS: Fifty male Sprague Dawley (SD) rats were randomized into control (n = 10), model (n = 13), EA-ST 36-SP 6 (n = 14) and EA-ACR (n = 13) groups. T 2 DM model was established by intraperitoneal injection of 1% STZ (50 mg/kg) and by feeding the animals with high-fat diet for 30 days. EA (15 Hz, 1 mA) was applied to bilateral "Zusanli" (ST 36), "Sanyinjiao" (SP 6) and ACR respectively for 30 min, once daily for 14 days. Multi Probe Adapter 9 skin measurement system (MPA 9) was used to measure the stratum corneum hydration (SCH), transepidermal water loss (TEWL), erythema index (El), melanin index (MI) and chromatic aberration values (L. a. b.) of the abdomenal and back (L1 - L6) skin, respectively. RESULTS: In comparison with the control group and pre-modeling, blood glucose contents of the model, EA-ST 36-SP 6 and EA-ACR groups were increased significantly (P < 0.01) after modeling. Compared with the model group, blood glucose levels of both EA-ST 36-SP 6 and EA-ACR groups were down-regulated apparently (P < 0.01) after treatment. Thirty days after modeling, the SCH, TEWL, EI, MI, L. and a. levels of the back skin, and the SCH and L. levels of the abdominal skin were decreased significantly (P < 0.05), while the level of b. in the back skin, and those of TEWL, EL, a. and b. of the abdominal skin increased considerably in the model group (P < 0.05). After EA, the levels of SCH, TEWL MI, L. a. and b. in the EA-ST 36-SP 6 group, SCH, TEWL, L. and b. in the EA-ACR group of the back skin, and SCH, L. and b. of both EAST 36-SP 6 and EA-ACR groups, as well as EI and a. of the EA-ST 36-SP 6 group of the abdominal skin were reversed remarkably (P < 0.05). No significant differences were found between the EA-ST 36-SP 6 and model groups in the levels of El of the back skin, TEWL and MI of the abdominal skin, and between the EA-ACR and model groups in the levels of SCH, EI, MI and a. of the back skin, and TEWL, EI, MI and a. of the abdominal skin (P > 0.05). In spite of a mildly better therapeutic effect of EA-ST 36-SP 6 in regulating some of the abovementioned indexes, no significant differences were found between the two EA groups in all the indexes (P > 0.05). CONCLUSION: EA of both ST 36-SP 6 and ACR can effectively down-regulate blood glucose level, suppress DM-induced decrease of SCH, TEWL, L. and a. of the back skin, and SCH of the abdominal skin, and down-regulate b. levels of the back and abdominal skin in T 2 DM rats, showing an improvement of the impaired skin barrier and color changes following EA intervention. SN - 1000-0607 UR - https://www.unboundmedicine.com/medline/citation/23650793/[Electroacupuncture_intervention_improved_changes_of_skin_barrier_and_color_in_type_2_diabetes_rats]_ L2 - http://www.diseaseinfosearch.org/result/2243 DB - PRIME DP - Unbound Medicine ER -