Tags

Type your tag names separated by a space and hit enter

Quinolone alkaloids with antibacterial and cytotoxic activities from the fruits of Evodia rutaecarpa.
Fitoterapia. 2013 Sep; 89:1-7.F

Abstract

Five new quinolone alkaloids, euocarpines A-E (16-20), four new natural products (1, 4, 12, and 14), and eleven known natural products were isolated from the fruits of Evodia rutaecarpa (Juss.) Benth. The structures of the new compounds were elucidated based on spectroscopic evidence. All compounds were evaluated for their antibacterial activity against three strains and for their cytotoxic activity against four human tumor cell lines. The results revealed that 5, 7-11, 13, 14, and 16-20 exhibited moderate antibacterial activities (MIC values: 4-128 μg/mL), and 9, 11, 14, and 17 exhibited moderate cytotoxic activities against HepG-2, Hela, BEL7402, and BEL7403 (IC50 values: 15.85-56.36 μM).

Links

Publisher Full Text

Authors+Show Affiliations

Wang XX
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Zan K
No affiliation info available
Shi SP
No affiliation info available
Zeng KW
No affiliation info available
Jiang Y
No affiliation info available
Guan Y
No affiliation info available
Xiao CL
No affiliation info available
Gao HY
No affiliation info available
Wu LJ
No affiliation info available
Tu PF
No affiliation info available

MeSH

AlkaloidsAnti-Bacterial AgentsAntineoplastic Agents, PhytogenicBacteriaEvodiaFruitHeLa CellsHep G2 CellsHumansMicrobial Sensitivity TestsMolecular StructureNeoplasmsPhytotherapyPlant ExtractsQuinolones

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23651559

Citation

Wang, Xiao-Xia, et al. "Quinolone Alkaloids With Antibacterial and Cytotoxic Activities From the Fruits of Evodia Rutaecarpa." Fitoterapia, vol. 89, 2013, pp. 1-7.
Wang XX, Zan K, Shi SP, et al. Quinolone alkaloids with antibacterial and cytotoxic activities from the fruits of Evodia rutaecarpa. Fitoterapia. 2013;89:1-7.
Wang, X. X., Zan, K., Shi, S. P., Zeng, K. W., Jiang, Y., Guan, Y., Xiao, C. L., Gao, H. Y., Wu, L. J., & Tu, P. F. (2013). Quinolone alkaloids with antibacterial and cytotoxic activities from the fruits of Evodia rutaecarpa. Fitoterapia, 89, 1-7. https://doi.org/10.1016/j.fitote.2013.04.007
Wang XX, et al. Quinolone Alkaloids With Antibacterial and Cytotoxic Activities From the Fruits of Evodia Rutaecarpa. Fitoterapia. 2013;89:1-7. PubMed PMID: 23651559.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quinolone alkaloids with antibacterial and cytotoxic activities from the fruits of Evodia rutaecarpa. AU - Wang,Xiao-Xia, AU - Zan,Ke, AU - Shi,She-Po, AU - Zeng,Ke-Wu, AU - Jiang,Yong, AU - Guan,Yan, AU - Xiao,Chun-Ling, AU - Gao,Hui-Yuan, AU - Wu,Li-Jun, AU - Tu,Peng-Fei, Y1 - 2013/05/04/ PY - 2013/02/07/received PY - 2013/04/13/revised PY - 2013/04/28/accepted PY - 2013/5/9/entrez PY - 2013/5/9/pubmed PY - 2014/2/28/medline KW - Antibacterial activity KW - Cytotoxic activity KW - Evodia rutaecarpa KW - Quinolone alkaloids SP - 1 EP - 7 JF - Fitoterapia JO - Fitoterapia VL - 89 N2 - Five new quinolone alkaloids, euocarpines A-E (16-20), four new natural products (1, 4, 12, and 14), and eleven known natural products were isolated from the fruits of Evodia rutaecarpa (Juss.) Benth. The structures of the new compounds were elucidated based on spectroscopic evidence. All compounds were evaluated for their antibacterial activity against three strains and for their cytotoxic activity against four human tumor cell lines. The results revealed that 5, 7-11, 13, 14, and 16-20 exhibited moderate antibacterial activities (MIC values: 4-128 μg/mL), and 9, 11, 14, and 17 exhibited moderate cytotoxic activities against HepG-2, Hela, BEL7402, and BEL7403 (IC50 values: 15.85-56.36 μM). SN - 1873-6971 UR - https://www.unboundmedicine.com/medline/citation/23651559/Quinolone_alkaloids_with_antibacterial_and_cytotoxic_activities_from_the_fruits_of_Evodia_rutaecarpa_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0367-326X(13)00116-0 DB - PRIME DP - Unbound Medicine ER -