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Vitamin B12 deficiency among patients with diabetes mellitus: is routine screening and supplementation justified?
J Diabetes Metab Disord 2013; 12(1):17JD

Abstract

Vitamin B12 is an essential micronutrient required for optimal hemopoetic, neuro-cognitive and cardiovascular function. Biochemical and clinical vitamin B12 deficiency has been demonstrated to be highly prevalent among patients with type 1 and type 2 diabetes mellitus. It presents with diverse clinical manifestations ranging from impaired memory, dementia, delirium, peripheral neuropathy, sub acute combined degeneration of the spinal cord, megaloblastic anemia and pancytopenia. This review article offers a current perspective on the physiological roles of vitamin B12, proposed pathophysiological mechanisms of vitamin B12 deficiency, screening for vitamin B12 deficiency and vitamin B12 supplementation among patients with diabetes mellitus.

Authors+Show Affiliations

Department of Medicine, St, Raphael of St, Francis hospital Nsambya, P,O,BOX 7146, Kampala, Uganda. davouirek@yahoo.co.uk.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23651730

Citation

Kibirige, Davis, and Raymond Mwebaze. "Vitamin B12 Deficiency Among Patients With Diabetes Mellitus: Is Routine Screening and Supplementation Justified?" Journal of Diabetes and Metabolic Disorders, vol. 12, no. 1, 2013, p. 17.
Kibirige D, Mwebaze R. Vitamin B12 deficiency among patients with diabetes mellitus: is routine screening and supplementation justified? J Diabetes Metab Disord. 2013;12(1):17.
Kibirige, D., & Mwebaze, R. (2013). Vitamin B12 deficiency among patients with diabetes mellitus: is routine screening and supplementation justified? Journal of Diabetes and Metabolic Disorders, 12(1), p. 17. doi:10.1186/2251-6581-12-17.
Kibirige D, Mwebaze R. Vitamin B12 Deficiency Among Patients With Diabetes Mellitus: Is Routine Screening and Supplementation Justified. J Diabetes Metab Disord. 2013 May 7;12(1):17. PubMed PMID: 23651730.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin B12 deficiency among patients with diabetes mellitus: is routine screening and supplementation justified? AU - Kibirige,Davis, AU - Mwebaze,Raymond, Y1 - 2013/05/07/ PY - 2012/11/04/received PY - 2013/05/02/accepted PY - 2013/5/9/entrez PY - 2013/5/9/pubmed PY - 2013/5/9/medline SP - 17 EP - 17 JF - Journal of diabetes and metabolic disorders JO - J Diabetes Metab Disord VL - 12 IS - 1 N2 - Vitamin B12 is an essential micronutrient required for optimal hemopoetic, neuro-cognitive and cardiovascular function. Biochemical and clinical vitamin B12 deficiency has been demonstrated to be highly prevalent among patients with type 1 and type 2 diabetes mellitus. It presents with diverse clinical manifestations ranging from impaired memory, dementia, delirium, peripheral neuropathy, sub acute combined degeneration of the spinal cord, megaloblastic anemia and pancytopenia. This review article offers a current perspective on the physiological roles of vitamin B12, proposed pathophysiological mechanisms of vitamin B12 deficiency, screening for vitamin B12 deficiency and vitamin B12 supplementation among patients with diabetes mellitus. SN - 2251-6581 UR - https://www.unboundmedicine.com/medline/citation/23651730/full_citation L2 - https://jdmdonline.biomedcentral.com/articles/10.1186/2251-6581-12-17 DB - PRIME DP - Unbound Medicine ER -