Tags

Type your tag names separated by a space and hit enter

Novel use of topical dapsone 5% gel for erythema elevatum diutinum: safer and effective.
J Drugs Dermatol. 2013 Apr; 12(4):481-4.JD

Abstract

We present a case of an otherwise healthy 81-year-old gentleman with multiple asymptomatic, erythematous, indurated papules and plaques, ranging in size from 0.5 to 1.5 cm, involving the dorsal, lateral, and palmar surfaces of the fingers bilaterally. A clinical suspicion of erythema elevatum diutinum (EED) led to initial treatment with topical dapsone 5% gel (ACZONE; Allergan Inc, Irvine, CA). Lesional biopsy demonstrated a dense perivascular infiltration of polymorphonuclear leukocytes and chronic inflammatory cells with perivascular fibrin deposition. Focal neutrophilic infiltration of superficial dermal blood vessel walls was present, suggesting a leukocytoclastic vasculitis. Stains for bacteria and fungi were negative. Clinicopathologic findings were consistent with EED, and in the interim, improvement with topical dapsone 5% gel was noted. Addition of oral dapsone led to complete resolution of the lesions. We present this case to illustrate the subtle, indolent clinical presentation of EED and demonstrate the uncomplicated use of topical dapsone 5% gel for rapid improvement and subsequent successful treatment of localized disease.

Authors+Show Affiliations

Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA. gfrielin@bidmc.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

23652900

Citation

Frieling, Gretchen W., et al. "Novel Use of Topical Dapsone 5% Gel for Erythema Elevatum Diutinum: Safer and Effective." Journal of Drugs in Dermatology : JDD, vol. 12, no. 4, 2013, pp. 481-4.
Frieling GW, Williams NL, Lim SJ, et al. Novel use of topical dapsone 5% gel for erythema elevatum diutinum: safer and effective. J Drugs Dermatol. 2013;12(4):481-4.
Frieling, G. W., Williams, N. L., Lim, S. J., & Rosenthal, S. I. (2013). Novel use of topical dapsone 5% gel for erythema elevatum diutinum: safer and effective. Journal of Drugs in Dermatology : JDD, 12(4), 481-4.
Frieling GW, et al. Novel Use of Topical Dapsone 5% Gel for Erythema Elevatum Diutinum: Safer and Effective. J Drugs Dermatol. 2013;12(4):481-4. PubMed PMID: 23652900.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Novel use of topical dapsone 5% gel for erythema elevatum diutinum: safer and effective. AU - Frieling,Gretchen W, AU - Williams,Noelle L, AU - Lim,Scott J M, AU - Rosenthal,Seth I, PY - 2013/5/9/entrez PY - 2013/5/9/pubmed PY - 2013/11/20/medline SP - 481 EP - 4 JF - Journal of drugs in dermatology : JDD JO - J Drugs Dermatol VL - 12 IS - 4 N2 - We present a case of an otherwise healthy 81-year-old gentleman with multiple asymptomatic, erythematous, indurated papules and plaques, ranging in size from 0.5 to 1.5 cm, involving the dorsal, lateral, and palmar surfaces of the fingers bilaterally. A clinical suspicion of erythema elevatum diutinum (EED) led to initial treatment with topical dapsone 5% gel (ACZONE; Allergan Inc, Irvine, CA). Lesional biopsy demonstrated a dense perivascular infiltration of polymorphonuclear leukocytes and chronic inflammatory cells with perivascular fibrin deposition. Focal neutrophilic infiltration of superficial dermal blood vessel walls was present, suggesting a leukocytoclastic vasculitis. Stains for bacteria and fungi were negative. Clinicopathologic findings were consistent with EED, and in the interim, improvement with topical dapsone 5% gel was noted. Addition of oral dapsone led to complete resolution of the lesions. We present this case to illustrate the subtle, indolent clinical presentation of EED and demonstrate the uncomplicated use of topical dapsone 5% gel for rapid improvement and subsequent successful treatment of localized disease. SN - 1545-9616 UR - https://www.unboundmedicine.com/medline/citation/23652900/Novel_use_of_topical_dapsone_5_gel_for_erythema_elevatum_diutinum:_safer_and_effective_ L2 - http://jddonline.com/articles/dermatology/S1545961613P0481X DB - PRIME DP - Unbound Medicine ER -