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Association between the interleukin 6 genotype at position -174 and atopic dermatitis.

Abstract

BACKGROUND

Atopic dermatitis (AD) is a chronic skin disorder of unknown origin that usually manifests for the first time in early infancy. Different types of genetic predisposition and environmental factors seem to be associated with the disease.

METHODS

This study was performed to evaluate the frequency of alleles, genotypes, and haplotypes of interleukin (IL) 6 single-nucleotide polymorphisms (SNPs) at positions -174 and nt565 in 89 Iranian children with AD and 139 healthy controls.

RESULTS

The G allele was significantly more frequent at position -174 in IL6 in atopic patients than in the healthy controls (P < .001; OR, 2.82). Genotype GG was found at the same position in 71% of the patients; this frequency was significantly higher than the frequency of 30% recorded in the controls (P < .001; OR, 5.60). The GG haplotype of IL6 (-174, nt565) was significantly more frequent in the atopic patients than in the healthy controls (P < .001; OR, 2.99).

CONCLUSIONS

A significant increase in the frequency of the G allele and GG genotype at position -174 of IL6 was found in patients with AD, thus suggesting that production of this cytokine is greater in atopic patients.

Authors+Show Affiliations

Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23654074

Citation

Gharagozlou, M, et al. "Association Between the Interleukin 6 Genotype at Position -174 and Atopic Dermatitis." Journal of Investigational Allergology & Clinical Immunology, vol. 23, no. 2, 2013, pp. 89-93.
Gharagozlou M, Farhadi E, Khaledi M, et al. Association between the interleukin 6 genotype at position -174 and atopic dermatitis. J Investig Allergol Clin Immunol. 2013;23(2):89-93.
Gharagozlou, M., Farhadi, E., Khaledi, M., Behniafard, N., Sotoudeh, S., Salari, R., ... Rezaei, N. (2013). Association between the interleukin 6 genotype at position -174 and atopic dermatitis. Journal of Investigational Allergology & Clinical Immunology, 23(2), pp. 89-93.
Gharagozlou M, et al. Association Between the Interleukin 6 Genotype at Position -174 and Atopic Dermatitis. J Investig Allergol Clin Immunol. 2013;23(2):89-93. PubMed PMID: 23654074.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between the interleukin 6 genotype at position -174 and atopic dermatitis. AU - Gharagozlou,M, AU - Farhadi,E, AU - Khaledi,M, AU - Behniafard,N, AU - Sotoudeh,S, AU - Salari,R, AU - Darabi,B, AU - Fathi,S M, AU - Mahmoudi,M, AU - Aghamohammadi,A, AU - Amirzargar,A A, AU - Rezaei,N, PY - 2013/5/10/entrez PY - 2013/5/10/pubmed PY - 2013/6/14/medline SP - 89 EP - 93 JF - Journal of investigational allergology & clinical immunology JO - J Investig Allergol Clin Immunol VL - 23 IS - 2 N2 - BACKGROUND: Atopic dermatitis (AD) is a chronic skin disorder of unknown origin that usually manifests for the first time in early infancy. Different types of genetic predisposition and environmental factors seem to be associated with the disease. METHODS: This study was performed to evaluate the frequency of alleles, genotypes, and haplotypes of interleukin (IL) 6 single-nucleotide polymorphisms (SNPs) at positions -174 and nt565 in 89 Iranian children with AD and 139 healthy controls. RESULTS: The G allele was significantly more frequent at position -174 in IL6 in atopic patients than in the healthy controls (P < .001; OR, 2.82). Genotype GG was found at the same position in 71% of the patients; this frequency was significantly higher than the frequency of 30% recorded in the controls (P < .001; OR, 5.60). The GG haplotype of IL6 (-174, nt565) was significantly more frequent in the atopic patients than in the healthy controls (P < .001; OR, 2.99). CONCLUSIONS: A significant increase in the frequency of the G allele and GG genotype at position -174 of IL6 was found in patients with AD, thus suggesting that production of this cytokine is greater in atopic patients. SN - 1018-9068 UR - https://www.unboundmedicine.com/medline/citation/23654074/Association_between_the_interleukin_6_genotype_at_position__174_and_atopic_dermatitis_ L2 - http://www.jiaci.org/issues/vol23issue2/vol23issue02-2.htm DB - PRIME DP - Unbound Medicine ER -