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Tibetan sound meditation for cognitive dysfunction: results of a randomized controlled pilot trial.
Psychooncology 2013; 22(10):2354-63P

Abstract

OBJECTIVE

Although chemotherapy-induced cognitive impairment is common among breast cancer patients, evidence for effective interventions addressing cognitive deficits is limited. This randomized controlled trial examined the feasibility and preliminary efficacy of a Tibetan Sound Meditation (TSM) program to improve cognitive function and quality of life in breast cancer patients.

METHODS

Forty-seven breast cancer patients (mean age 56.3 years), who were staged I-III at diagnosis, 6-60 months post-chemotherapy, and reported cognitive impairment at study entry were recruited. Participants were randomized to either two weekly TSM sessions for 6 weeks or a wait list control group. Neuropsychological assessments were completed at baseline and 1 month post-treatment. Self-report measures of cognitive function (Functional Assessment of Cancer Therapy (FACT)-Cog), quality of life (SF-36), depressive symptoms (Center for Epidemiologic Studies Depression Scale), sleep disturbance (Pittsburgh Sleep Quality Index), fatigue (Brief Fatigue Inventory), and spirituality (FACT-Sp) were completed at baseline, the end of treatment, and 1 month later.

RESULTS

Relative to the control group, women in the TSM group performed better on the verbal memory test (Rey Auditory Verbal Learning Test trial 1) (p = 0.06) and the short-term memory and processing speed task (Digit Symbol) (p = 0.09) and reported improved cognitive function (p = 0.06), cognitive abilities (p = 0.08), mental health (p = 0.04), and spirituality (p = 0.05) at the end of treatment but not 1 month later.

CONCLUSIONS

This randomized controlled trial revealed that TSM program appears to be a feasible and acceptable intervention and may be associated with short-term improvements in objective and subjective cognitive function as well as mental health and spirituality in breast cancer patients.

Authors+Show Affiliations

Department of General Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.Department of General Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.Health Policy Research Institute, University of California, Irvine, CA, USA.Ligmincha Institute, Shipman, VA, USA.Department of General Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA.Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA.Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, USA.Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA.Department of General Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23657969

Citation

Milbury, K, et al. "Tibetan Sound Meditation for Cognitive Dysfunction: Results of a Randomized Controlled Pilot Trial." Psycho-oncology, vol. 22, no. 10, 2013, pp. 2354-63.
Milbury K, Chaoul A, Biegler K, et al. Tibetan sound meditation for cognitive dysfunction: results of a randomized controlled pilot trial. Psychooncology. 2013;22(10):2354-63.
Milbury, K., Chaoul, A., Biegler, K., Wangyal, T., Spelman, A., Meyers, C. A., ... Cohen, L. (2013). Tibetan sound meditation for cognitive dysfunction: results of a randomized controlled pilot trial. Psycho-oncology, 22(10), pp. 2354-63. doi:10.1002/pon.3296.
Milbury K, et al. Tibetan Sound Meditation for Cognitive Dysfunction: Results of a Randomized Controlled Pilot Trial. Psychooncology. 2013;22(10):2354-63. PubMed PMID: 23657969.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tibetan sound meditation for cognitive dysfunction: results of a randomized controlled pilot trial. AU - Milbury,K, AU - Chaoul,A, AU - Biegler,K, AU - Wangyal,T, AU - Spelman,A, AU - Meyers,C A, AU - Arun,B, AU - Palmer,J L, AU - Taylor,J, AU - Cohen,L, Y1 - 2013/05/09/ PY - 2012/11/16/received PY - 2013/03/15/revised PY - 2013/03/27/accepted PY - 2013/5/10/entrez PY - 2013/5/10/pubmed PY - 2015/10/27/medline KW - breast cancer KW - chemotherapy KW - cognitive dysfunction KW - meditation;mental health KW - quality of life SP - 2354 EP - 63 JF - Psycho-oncology JO - Psychooncology VL - 22 IS - 10 N2 - OBJECTIVE: Although chemotherapy-induced cognitive impairment is common among breast cancer patients, evidence for effective interventions addressing cognitive deficits is limited. This randomized controlled trial examined the feasibility and preliminary efficacy of a Tibetan Sound Meditation (TSM) program to improve cognitive function and quality of life in breast cancer patients. METHODS: Forty-seven breast cancer patients (mean age 56.3 years), who were staged I-III at diagnosis, 6-60 months post-chemotherapy, and reported cognitive impairment at study entry were recruited. Participants were randomized to either two weekly TSM sessions for 6 weeks or a wait list control group. Neuropsychological assessments were completed at baseline and 1 month post-treatment. Self-report measures of cognitive function (Functional Assessment of Cancer Therapy (FACT)-Cog), quality of life (SF-36), depressive symptoms (Center for Epidemiologic Studies Depression Scale), sleep disturbance (Pittsburgh Sleep Quality Index), fatigue (Brief Fatigue Inventory), and spirituality (FACT-Sp) were completed at baseline, the end of treatment, and 1 month later. RESULTS: Relative to the control group, women in the TSM group performed better on the verbal memory test (Rey Auditory Verbal Learning Test trial 1) (p = 0.06) and the short-term memory and processing speed task (Digit Symbol) (p = 0.09) and reported improved cognitive function (p = 0.06), cognitive abilities (p = 0.08), mental health (p = 0.04), and spirituality (p = 0.05) at the end of treatment but not 1 month later. CONCLUSIONS: This randomized controlled trial revealed that TSM program appears to be a feasible and acceptable intervention and may be associated with short-term improvements in objective and subjective cognitive function as well as mental health and spirituality in breast cancer patients. SN - 1099-1611 UR - https://www.unboundmedicine.com/medline/citation/23657969/Tibetan_sound_meditation_for_cognitive_dysfunction:_results_of_a_randomized_controlled_pilot_trial_ L2 - https://doi.org/10.1002/pon.3296 DB - PRIME DP - Unbound Medicine ER -