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Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with relapsing-remitting multiple sclerosis.
Int J Neurosci 2013; 123(11):776-82IJ

Abstract

BACKGROUND

Multiple sclerosis (MS) is a chronic inflammatory disease of central nervous system in which a higher oxidative stress may contribute to its pathogenesis. The aim of this study was to investigate the effect of coenzyme Q10 (CoQ10) supplementation on oxidative stress and antioxidant enzyme activity in patients with MS.

MATERIALS AND METHODS

We performed a randomized, double-blinded, placebo-controlled trail to determine the effect of CoQ10 supplement (500 mg/day, n = 24) versus placebo (controls, n = 24) for 12 weeks. Fasting blood samples were taken before and after a 12-week intervention to analyze malondialdehyde (MDA), total antioxidant capacity (TAC) and antioxidant enzymes [superoxide dismutase (SOD), glutathione peroxidase (GPx)] activity.

RESULTS

Forty-five subjects with MS completed intervention study. After 12 weeks, CoQ10-treated patients had significant increase in SOD activity (p = 0.013); and decrease in MDA levels (P=0.003) compared with controls. Despite the significant effect of CoQ10 supplementation on plasma TAC (p = 0.010), no significant differences were found between the two groups. CoQ10 supplementation did not affect GPx activity.

CONCLUSION

Present study suggests that CoQ10 supplements at a dose of 500 mg/day can decrease oxidative stress and increase antioxidant enzyme activity in patients with relapsing-remitting MS.

Authors+Show Affiliations

1Department of Clinical Nutrition, School of Nutritional Sciences & Dietetics, Tehran University of Medical Sciences , Tehran , Islamic Republic of Iran.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

23659338

Citation

Sanoobar, Meisam, et al. "Coenzyme Q10 Supplementation Reduces Oxidative Stress and Increases Antioxidant Enzyme Activity in Patients With Relapsing-remitting Multiple Sclerosis." The International Journal of Neuroscience, vol. 123, no. 11, 2013, pp. 776-82.
Sanoobar M, Eghtesadi S, Azimi A, et al. Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with relapsing-remitting multiple sclerosis. Int J Neurosci. 2013;123(11):776-82.
Sanoobar, M., Eghtesadi, S., Azimi, A., Khalili, M., Jazayeri, S., & Reza Gohari, M. (2013). Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with relapsing-remitting multiple sclerosis. The International Journal of Neuroscience, 123(11), pp. 776-82. doi:10.3109/00207454.2013.801844.
Sanoobar M, et al. Coenzyme Q10 Supplementation Reduces Oxidative Stress and Increases Antioxidant Enzyme Activity in Patients With Relapsing-remitting Multiple Sclerosis. Int J Neurosci. 2013;123(11):776-82. PubMed PMID: 23659338.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with relapsing-remitting multiple sclerosis. AU - Sanoobar,Meisam, AU - Eghtesadi,Shahryar, AU - Azimi,Amirreza, AU - Khalili,Mohammad, AU - Jazayeri,Shima, AU - Reza Gohari,Mahmood, Y1 - 2013/06/17/ PY - 2013/5/11/entrez PY - 2013/5/11/pubmed PY - 2014/5/20/medline SP - 776 EP - 82 JF - The International journal of neuroscience JO - Int. J. Neurosci. VL - 123 IS - 11 N2 - BACKGROUND: Multiple sclerosis (MS) is a chronic inflammatory disease of central nervous system in which a higher oxidative stress may contribute to its pathogenesis. The aim of this study was to investigate the effect of coenzyme Q10 (CoQ10) supplementation on oxidative stress and antioxidant enzyme activity in patients with MS. MATERIALS AND METHODS: We performed a randomized, double-blinded, placebo-controlled trail to determine the effect of CoQ10 supplement (500 mg/day, n = 24) versus placebo (controls, n = 24) for 12 weeks. Fasting blood samples were taken before and after a 12-week intervention to analyze malondialdehyde (MDA), total antioxidant capacity (TAC) and antioxidant enzymes [superoxide dismutase (SOD), glutathione peroxidase (GPx)] activity. RESULTS: Forty-five subjects with MS completed intervention study. After 12 weeks, CoQ10-treated patients had significant increase in SOD activity (p = 0.013); and decrease in MDA levels (P=0.003) compared with controls. Despite the significant effect of CoQ10 supplementation on plasma TAC (p = 0.010), no significant differences were found between the two groups. CoQ10 supplementation did not affect GPx activity. CONCLUSION: Present study suggests that CoQ10 supplements at a dose of 500 mg/day can decrease oxidative stress and increase antioxidant enzyme activity in patients with relapsing-remitting MS. SN - 1563-5279 UR - https://www.unboundmedicine.com/medline/citation/23659338/Coenzyme_Q10_supplementation_reduces_oxidative_stress_and_increases_antioxidant_enzyme_activity_in_patients_with_relapsing_remitting_multiple_sclerosis_ L2 - http://www.tandfonline.com/doi/full/10.3109/00207454.2013.801844 DB - PRIME DP - Unbound Medicine ER -